White Matter Microstructural Correlates of Cognitive and Motor Functioning Revealed via Multimodal Multivariate Analysis DOI Creative Commons
Zaki Alasmar, Stefanie A Tremblay,

Tobias R. Baumeister

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

1. Abstract Recent advances in cognitive neuroscience emphasise the importance of healthy white matter (WM) optimal behavioural functioning. It is now widely accepted that brain connectivity via WM contributes to emergence behaviour. However, association between microstructure fibres and behaviour poorly understood. This part due indirect overlapping methods assessing microstructure, use overly simplistic approaches Here, we used Mahalanobis Distance (D2) integrate 10 metrics derived from multimodal neuroimaging have strong ties microstructure. The D2 metric was chosen because it accounts for metrics’ covariance as measures voxelwise distance every subject average; thus providing a robust multiparametric assessment To examine WM-behaviour associations, multivariate correlation correlates 2 motor tasks, which allowed us compare within across domains WM. We observed organised cognitive, motor, integrative variables are widespread their associations with WM, frontal parietal regions. Our results highlight complex nature behaviour, show need modelling when examining brain-behaviour associations.

Language: Английский

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases DOI Creative Commons
Jian Sheng Loh, Wen Qi Mak, Li Tan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Language: Английский

Citations

274
Neuron–oligodendroglial interactions in health and malignant disease DOI
Kathryn R. Taylor, Michelle Monje

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(12), P. 733 - 746

Published: Oct. 19, 2023

Language: Английский

Citations

34
Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology DOI Creative Commons

Peibin Zou,

Chongyun Wu,

Timon Cheng‐Yi Liu

et al.

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: Nov. 14, 2023

Abstract Oligodendrocyte progenitor cells (OPCs) play pivotal roles in myelin formation and phagocytosis, communicating with neighboring contributing to the integrity of blood–brain barrier (BBB). However, under pathological circumstances Alzheimer’s disease (AD), brain’s microenvironment undergoes detrimental changes that significantly impact OPCs their functions. Starting OPC functions, we delve into transformation myelin-producing oligodendrocytes, intricate signaling interactions other central nervous system (CNS), fascinating process which influences function affects CNS homeostasis. Moreover, discuss essential role BBB highlight critical contribution forming CNS-protective barriers. In context AD, deterioration local brain is discussed, mainly focusing on neuroinflammation, oxidative stress, accumulation toxic proteins. The disturb delicate balance brain, impacting regenerative capacity compromising integrity. Under conditions, experience significant alterations migration proliferation, leading impaired differentiation a reduced ability produce mature oligodendrocytes. degeneration become increasingly active progressive neurodegeneration. Finally, summarize current therapeutic approaches targeting AD. Strategies revitalize senescence, modulate pathways enhance differentiation, explore potential avenues are promising alleviating AD function. conclusion, this review highlights indispensable involvement pathogenesis interplay between underscores complexity neurodegenerative diseases. Insights from studying conditions provide foundation for innovative strategies fostering Future research will advance our understanding management diseases, ultimately offering hope effective treatments improved quality life those affected by related disorders.

Language: Английский

Citations

28
Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex DOI
Daniela J. Di Bella, Nuria Domıńguez-Iturza, Juliana Brown

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(13), P. 2091 - 2111

Published: May 15, 2024

Language: Английский

Citations

17
Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration DOI
Xuezhao Liu, Dazhuan Xin,

Xiaowen Zhong

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(10), P. 2465 - 2484.e22

Published: May 1, 2024

Language: Английский

Citations

11
Inflammaging and Brain Aging DOI Open Access
Maria Carolina Jurcău, Anamaria Jurcău,

Alexander Cristian

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10535 - 10535

Published: Sept. 30, 2024

Progress made by the medical community in increasing lifespans comes with costs of incidence and prevalence age-related diseases, neurodegenerative ones included. Aging is associated a series morphological changes at tissue cellular levels brain, as well impairments signaling pathways gene transcription, which lead to synaptic dysfunction cognitive decline. Although we are not able pinpoint exact differences between healthy aging neurodegeneration, research increasingly highlights involvement neuroinflammation chronic systemic inflammation (inflammaging) development age-associated via pathogenic cascades, triggered dysfunctions circadian clock, gut dysbiosis, immunosenescence, or impaired cholinergic signaling. In addition, gender susceptibility course neurodegeneration that appear be mediated glial cells emphasize need for future this area an individualized therapeutic approach. rejuvenation still its very early infancy, accumulated knowledge on various involved promoting senescence opens perspective interfering these preventing delaying senescence.

Language: Английский

Citations

10
Reversible reduction in brain myelin content upon marathon running DOI Creative Commons
Pedro Ramos‐Cabrer, Alberto Cabrera‐Zubizarreta, Daniel Padró

et al.

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Here we use magnetic resonance imaging to study the impact of marathon running on brain structure in humans. We show that signal for myelin water fraction—a surrogate content—is substantially reduced upon specific regions involved motor coordination and sensory emotional integration, but recovers within two months. These findings suggest content is temporarily reversibly diminished by severe exercise, a finding consistent with recent evidence from rodent studies lipids may act as glial energy reserves extreme metabolic conditions. Using runners, Ramos-Cabrer, Cabrera-Zubizarreta et al. report detected significantly after fully recovered

Language: Английский

Citations

2
Entangled biphoton generation in the myelin sheath DOI
Zefei Liu, Yong-Cong Chen,

Ping Ao

et al.

Physical review. E, Journal Year: 2024, Volume and Issue: 110(2)

Published: Aug. 2, 2024

Consciousness within the brain hinges on synchronized activities of millions neurons, but mechanism responsible for orchestrating such synchronization remains elusive. In this study we employ cavity quantum electrodynamics to explore entangled biphoton generation through cascade emission in vibration spectrum C-H bonds lipid molecules' tails. The results indicate that cylindrical formed by a myelin sheath can facilitate spontaneous photon from vibrational modes and generate significant number pairs. abundance bond units neurons therefore serve as source entanglement resources nervous system. These findings may offer insight into brain's ability leverage these information transfer, thereby elucidating potential activity neurons.

Language: Английский

Citations

7
Clemastine-induced enhancement of hippocampal myelination alleviates memory impairment in mice with chronic pain DOI Creative Commons
Tingting Zhu, He Wang,

Pan-miao Liu

et al.

Neurobiology of Disease, Journal Year: 2023, Volume and Issue: 190, P. 106375 - 106375

Published: Dec. 11, 2023

Patients with chronic pain often experience memory impairment, but the underlying mechanisms remain elusive. The myelin sheath is crucial for rapid and accurate action potential conduction, playing a pivotal role in development of cognitive abilities central nervous system. study reveals that degradation occurs hippocampus constriction injury (CCI) mice, which display both impairment. Using fiber photometry, we observed diminished task-related neuronal activity CCI mice. Interestingly, repeated administration clemastine, promotes myelination, counteracts CCI-induced loss reduced activity. Notably, clemastine specifically ameliorates impaired without affecting Overall, our findings highlight significant abnormalities suggesting therapeutic approach treating impairments associated neuropathic pain.

Language: Английский

Citations

14
Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection DOI Creative Commons
Jennifer Tisoncik-Go, Caleb Stokes, Leanne S. Whitmore

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 18, 2024

Abstract Zika virus (ZikV) infection during pregnancy can cause congenital syndrome (CZS) and neurodevelopmental delay in infants, of which the pathogenesis remains poorly understood. We utilize an established female pigtail macaque maternal-to-fetal ZikV infection/exposure model to study fetal brain pathophysiology CZS manifesting from exposure utero. find prenatal leads profound disruption myelin, with extensive downregulation gene expression for key components oligodendrocyte maturation myelin production. Immunohistochemical analyses reveal marked decreases basic protein intensity myelinated fiber density ZikV-exposed animals. At ultrastructural level, sheath animals shows multi-focal decompaction, occurring concomitant dysregulation maturation. These findings define neuropathological profiles ZikV-linked injury underlying resulting Because is critical cortical development, ZikV-related perturbations function may have long-term consequences on childhood neurodevelopment, even absence overt microcephaly.

Language: Английский

Citations

6