A Review of Curcumin and Its Derivatives as Anticancer Agents

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(5), P. 1033 - 1033

Published: Feb. 27, 2019

Cancer is the second leading cause of death in world and one major public health problems. Despite great advances cancer therapy, incidence mortality rates remain high. Therefore, quest for more efficient less toxic treatment strategies still at forefront current research. Curcumin, active ingredient Curcuma longa plant, has received attention over past two decades as an antioxidant, anti-inflammatory, anticancer agent. In this review, a summary medicinal chemistry pharmacology curcumin its derivatives regard to activity, their main mechanisms action, cellular targets been provided based on literature data from experimental clinical evaluation cell lines, animal models, human subjects. addition, recent drug delivery systems cells have highlighted.

Language: Английский

---

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Chinese Medicine, Journal Year: 2019, Volume and Issue: 14(1)

Published: Nov. 6, 2019

Abstract Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro vivo. To provide new insights into the critical path ahead, we systemically reviewed most recent advances (reported since 2011) on key compounds with effects derived (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic artesunate, wogonin, β-elemene, cepharanthine) scientific databases (PubMed, Web of Science, Medline, Scopus, Clinical Trials). With a broader perspective, focused their recently discovered and/or investigated pharmacological novel mechanism action, relevant clinical studies, innovative applications combined therapy immunomodulation. In addition, present review has extended to describe other promising dihydroartemisinin, Rh2, compound K, cucurbitacins D, E, IIA cryptotanshinone view potentials cancer therapy. Up now, evidence about immunomodulatory trials is very limited, further research needed monitor immunoregulatory explore mechanisms action modulators immune checkpoints.

Language: Английский

---

Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers

Biomolecules, Journal Year: 2021, Volume and Issue: 11(3), P. 392 - 392

Published: March 7, 2021

Cancer is a major burden of disease globally. Each year, tens millions people are diagnosed with cancer worldwide, and more than half the patients eventually die from it. Significant advances have been noticed in treatment, but mortality incidence rates cancers still high. Thus, there growing research interest developing effective less toxic treatment approaches. Curcumin (CUR), active component turmeric (Curcuma longa L.), has gained great as an antioxidant, anticancer, anti-inflammatory agent. This natural compound shows its anticancer effect through several pathways including interfering multiple cellular mechanisms inhibiting/inducing generation cytokines, enzymes, or growth factors IκB kinase β (IκKβ), tumor necrosis factor-alpha (TNF-α), signal transducer, activator transcription 3 (STAT3), cyclooxygenase II (COX-2), protein D1 (PKD1), nuclear factor-kappa B (NF-κB), epidermal factor, mitogen-activated (MAPK). Interestingly, activity CUR limited primarily due to poor water solubility, which can lead low chemical stability, oral bioavailability, uptake. Delivering drugs at controlled rate, slow delivery, targeted delivery other very attractive methods pursued vigorously. Multiple nanoformulations also developed so far ameliorate solubility bioavailability provide protection against hydrolysis inactivation. In this review, we summarized cancers, for example, gastrointestinal, head neck, brain, pancreatic, colorectal, breast, prostate cancers. addition, focused on findings obtained experimental clinical studies regarding animal models, human subjects, cell lines.

Language: Английский

---

Targeting Glucose Metabolism Enzymes in Cancer Treatment: Current and Emerging Strategies

Cancers, Journal Year: 2022, Volume and Issue: 14(19), P. 4568 - 4568

Published: Sept. 21, 2022

Reprogramming of glucose metabolism provides sufficient energy and raw materials for the proliferation, metastasis, immune escape cancer cells, which is enabled by metabolism-related enzymes that are abundantly expressed in a broad range cancers. Therefore, targeting has emerged as promising strategy anticancer drug development. Although several modulators have been approved treatment recent years, some limitations exist, such short half-life, poor solubility, numerous adverse effects. With rapid development medicinal chemicals, more advanced effective enzyme-targeted drugs developed. Additionally, studies found natural products can suppress progression regulating enzymes. In this review, we summarize mechanisms underlying reprogramming present could serve therapeutic targets. addition, systematically review existing enzymes, including small-molecule products. Finally, opportunities challenges also discussed. conclusion, combining with conventional may be strategy.

Language: Английский

---

Curcumin a Natural Phenol and Its Therapeutic Role in Cancer and Photodynamic Therapy: A Review

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 639 - 639

Published: Feb. 14, 2023

Cancer continues to cause an alarming number of deaths globally, and its burden on the health system is significant. Though different conventional therapeutic procedures are exploited for cancer treatment, prevalence death rates remain elevated. These, therefore, insinuate that novel more efficient treatment needed cancer. Curcumin, a bioactive, natural, phenolic compound isolated from rhizome herbaceous plant turmeric, receiving great interest exciting broad pharmacological properties. Curcumin presents anticancer capacities can be utilized as photosensitizing drug in photodynamic therapy (PDT). Nonetheless, curcumin′s poor bioavailability related pharmacokinetics limit clinical utility treatment. This review looks at physical chemical properties, bioavailability, safety curcumin, while focusing curcumin agent photosensitizer PDT. The possible mechanisms cellular targets PDT highlighted. Furthermore, recent improvements curcumin’s using nanoformulations delivery systems presented.

Language: Английский

---

Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future perspectives

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116034 - 116034

Published: Dec. 22, 2023

The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, depression. Most these benefits due to their anti-inflammatory antioxidant properties. Curcumin consumption leads decreased bioavailability, resulting limited absorption, quick metabolism, excretion, hinders health improvement. Numerous factors can increase its bioavailability. Piperine enhances bioavailability when combined with a complex. When other enhancing agents, has wide spectrum benefits. This review evaluates therapeutic potential specific emphasis on approach based molecular signaling pathways. study investigated influence progression cancer, inflammation, many health-related mechanisms, cell proliferation, apoptosis, metastasis. significant for prevention treatment various diseases. modulates several biochemical pathways targets involved cancer growth. Despite tissue accumulation administered orally, proven useful. provides in-depth analysis curcumin's applications, pathway-based approach, precision medicine human health.

Language: Английский

---

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(1)

Published: Jan. 1, 2024

Abstract Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness limited due to poor absorption rapid elimination the body. Various curcumin derivatives have also shown anticancer potential in‐vitro in‐vivo models. multiple signaling pathways development/progression or induce cell death through apoptosis. In addition, could enhance of conventional chemotherapy, radiation therapy reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored overcome challenges with curcumin's delivery, increasing overall efficacy. The use an imaging system track these formulations give beneficial information about bioavailability distribution nano‐curcumin complex. conclusion, holds significant promise fight against cancer, especially nanoform, provide precise cells without affecting normal healthy cells.

Language: Английский

---

Curcumin: New Insights into an Ancient Ingredient against Cancer

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(8), P. 1808 - 1808

Published: April 12, 2019

Cancer patients frequently use complementary medicine. Curcumin (CUR) and its derivates (from the extract of Curcuma longa L.) represent some most used ones, having a long history in traditional Asian CUR was demonstrated, both vitro vivo, to have significant anti-inflammatory effects, thus potentially counteracting cancer-promoting inflammation, which is hallmark cancer. modulate plethora signaling pathways cancer cells, comprising NF-κB (nuclear factor k-light-chain-enhancer activated B cells), JAK/STAT (Janus-Kinase/Signal Transducers Activators Transcription), TGF-β (transforming growth factor-β) pathways. Furthermore, confers properties electron receptors, destabilize radical oxygen species (ROS), explaining antioxidant anti-apopototic effects. Although has low bioavailability, role advanced treatment supportive care addressed numerous clinical trials. After promising results phase I–II trials, multiple III trials different indications are currently under way test for direct anti-cancer In addition, exerts beneficial effects on treatment-related neurotoxcity, cardiotoxicity, nephrotoxicity, hemato-toxicity, others. More efficient galenic formulations tested optimze CUR’s usability treatment. This review should provide comprehensive overview basic science, pre-clinical data field oncology.

Language: Английский

---

Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds

Cancers, Journal Year: 2020, Volume and Issue: 12(1), P. 154 - 154

Published: Jan. 8, 2020

Reprogramming of cellular energy metabolism is widely accepted to be a cancer hallmark. The deviant energetic cells-known as the Warburg effect-consists in much higher rates glucose uptake and glycolytic oxidation coupled with production lactic acid, even presence oxygen. Consequently, cells have needs thus display sensitivity deprivation-induced death than normal cells. So, inhibitors are potential therapeutic targets cancer. Breast most commonly diagnosed leading cause women worldwide. Overexpression facilitative transporters (GLUT), mainly GLUT1, breast firmly established, consequences GLUT inhibition and/or knockout under investigation. Herein we review compounds, both natural synthetic origin, found interfere by cells, interference that mechanism on cell biology. We will also present data where interaction exploited order increase efficiency or selectivity anticancer agents,

Language: Английский

---

Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review

Seminars in Cancer Biology, Journal Year: 2020, Volume and Issue: 80, P. 276 - 305

Published: Feb. 17, 2020

Language: Английский

---