Micromachines,
Journal Year:
2021,
Volume and Issue:
12(7), P. 808 - 808
Published: July 9, 2021
In
this
research,
glassy
carbon
electrode
(GCE)
amplified
with
single-wall
nanotubes
(SWCNTs)
and
ds-DNA
was
fabricated
utilized
for
voltammetric
sensing
of
doxorubicin
a
low
detection
limit.
technique,
the
reduction
in
guanine
signal
presence
(DOX)
chosen
as
an
analytical
factor.
The
molecular
docking
study
revealed
that
drug
interacted
DNA
through
intercalation
mode,
which
agreement
obtained
experimental
results.
DOX
performance
ds-DNA/SWCNTs/GCE
assessed
at
concentration
range
1.0
nM–20.0
µM.
limit
found
to
be
0.6
nM
comparable
even
better
(in
many
cases)
than
previous
electrochemical
reported
sensors.
final
step,
showed
powerful
ability
determination
injection
samples
acceptable
recovery
data.
Nano Convergence,
Journal Year:
2021,
Volume and Issue:
8(1)
Published: Nov. 2, 2021
Modern
medicine
has
been
waging
a
war
on
cancer
for
nearly
century
with
no
tangible
end
in
sight.
Cancer
treatments
have
significantly
progressed,
but
the
need
to
increase
specificity
and
decrease
systemic
toxicities
remains.
Early
diagnosis
holds
key
improving
prognostic
outlook
patient
quality
of
life,
diagnostic
tools
are
cusp
technological
revolution.
Nanotechnology
steadily
expanded
into
reaches
chemotherapy,
radiotherapy,
diagnostics,
imaging,
demonstrating
capacity
augment
each
advance
care.
Nanomaterials
provide
an
abundance
versatility,
functionality,
applications
engineer
specifically
targeted
medicine,
accurate
early-detection
devices,
robust
imaging
modalities,
enhanced
radiotherapy
adjuvants.
This
review
provides
insights
current
clinical
pre-clinical
nanotechnological
drug
therapy,
radiation
therapy.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(23), P. 7109 - 7109
Published: Nov. 24, 2021
Curcumin
is
the
primary
polyphenol
in
turmeric's
curcuminoid
class.
It
has
a
wide
range
of
therapeutic
applications,
such
as
anti-inflammatory,
antioxidant,
antidiabetic,
hepatoprotective,
antibacterial,
and
anticancer
effects
against
various
cancers,
but
poor
solubility
low
bioavailability.
Objective:
To
improve
curcumin's
bioavailability,
plasma
concentration,
cellular
permeability
processes.
The
nanocurcumin
approach
over
curcumin
been
proven
appropriate
for
encapsulating
or
loading
(nanocurcumin)
to
increase
its
potential.
Conclusion:
Though
incorporating
into
form
may
be
viable
method
overcoming
intrinsic
limitations,
there
are
reasonable
concerns
regarding
toxicological
safety
once
it
enters
biological
pathways.
This
review
article
mainly
highlights
benefits
curcumin.
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
12
Published: April 22, 2022
Colorectal
cancer
(CRC)
is
one
of
the
most
common
and
reoccurring
diseases,
as
well
world's
second
largest
cause
mortality.
Despite
existing
preventative,
diagnostic,
treatment
methods,
such
chemotherapy,
number
instances
rises
year
after
year.
As
a
result,
new
effective
medications
targeting
specific
checkpoints
should
be
developed
to
combat
CRC.
Natural
compounds,
curcumin,
have
shown
significant
anti-colorectal
characteristics
among
that
can
used
treat
These
chemicals
are
phenolic
compounds
belong
curcuminoids
category.
Curcumin
exerts
its
anti-proliferative
properties
against
CRC
cell
lines
in
vitro
vivo
via
variety
mechanisms,
including
suppression
intrinsic
extrinsic
apoptotic
signaling
pathways,
stoppage
cycle,
activation
autophagy.
also
has
anti-angiogenesis
properties.
Thus,
this
review
aimed
at
emphasizing
biological
effect
mode
action
curcumin
on
Furthermore,
critical
role
these
substances
chemoprevention
was
emphasized.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(16), P. 5236 - 5236
Published: Aug. 16, 2022
Throughout
the
United
States,
cancer
remains
second
leading
cause
of
death.
Traditional
treatments
induce
significant
medical
toxic
effects
and
unpleasant
adverse
reactions,
making
them
inappropriate
for
long-term
use.
Consequently,
anticancer-drug
resistance
relapse
are
frequent
in
certain
situations.
Thus,
there
is
an
urgent
necessity
to
find
effective
antitumor
medications
that
specific
have
few
consequences.
Curcumin
a
polyphenol
derivative
found
turmeric
plant
(Curcuma
longa
L.),
provides
chemopreventive,
antitumor,
chemo-,
radio-sensitizing
properties.
In
this
paper,
we
summarize
new
nano-based
formulations
polyphenolic
curcumin
because
growing
interest
its
application
against
cancers
tumors.
According
recent
studies,
use
nanoparticles
can
overcome
hydrophobic
nature
curcumin,
as
well
improving
stability
cellular
bioavailability
vitro
vivo.
Several
strategies
nanocurcumin
production
been
developed,
each
with
own
set
advantages
unique
features.
Because
majority
curcumin-based
nanoformulation
evidence
still
conceptual
stage,
numerous
issues
impeding
provision
possible
therapeutic
option.
To
support
science,
further
work
necessary
develop
viable
anti-cancer
adjuvant.
review,
cover
various
nanoformulations
implications
uses
cancer,
current
state
clinical
studies
patents.
We
address
knowledge
gaps
future
research
orientations
required
feasible
treatment
candidate.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(1)
Published: Jan. 1, 2024
Abstract
Curcumin
is
a
natural
compound
derived
from
turmeric
and
can
target
malignant
tumor
molecules
involved
in
cancer
propagation.
It
has
potent
antioxidant
activity,
but
its
effectiveness
limited
due
to
poor
absorption
rapid
elimination
the
body.
Various
curcumin
derivatives
have
also
shown
anticancer
potential
in‐vitro
in‐vivo
models.
multiple
signaling
pathways
development/progression
or
induce
cell
death
through
apoptosis.
In
addition,
could
enhance
of
conventional
chemotherapy,
radiation
therapy
reduce
their
associated
side
effects.
Lately,
nanoparticle‐based
delivery
systems
are
being
developed/explored
overcome
challenges
with
curcumin's
delivery,
increasing
overall
efficacy.
The
use
an
imaging
system
track
these
formulations
give
beneficial
information
about
bioavailability
distribution
nano‐curcumin
complex.
conclusion,
holds
significant
promise
fight
against
cancer,
especially
nanoform,
provide
precise
cells
without
affecting
normal
healthy
cells.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 121 - 121
Published: Jan. 16, 2025
In
the
21st
century,
thanks
to
advances
in
biotechnology
and
developing
pharmaceutical
technology,
significant
progress
is
being
made
effective
drug
design.
Drug
targeting
aims
ensure
that
acts
only
pathological
area;
it
defined
as
ability
accumulate
selectively
quantitatively
target
tissue
or
organ,
regardless
of
chemical
structure
active
substance
method
administration.
With
targeting,
conventional,
biotechnological
gene-derived
drugs
body’s
organs,
tissues,
cells
can
be
transported
specific
regions.
These
systems
serve
carriers
regulate
timing
release.
Despite
having
many
advantageous
features,
these
have
limitations
thoroughly
treating
complex
diseases
such
cancer.
Therefore,
combining
with
nanoparticle
technologies
imperative
treat
cancer
at
both
local
systemic
levels
effectively.
The
nanocarrier-based
delivery
involves
encapsulating
target-specific
molecules
into
polymeric
vesicular
systems.
Various
(DDS)
were
investigated
discussed
this
review
article.
first
part
passive
systems,
hydrogels,
thermoplastics,
microdevices
transdermal-based
second
carrier
nanobiotechnology
(carbon
nanotubes,
nanoparticles,
coated,
pegylated,
solid
lipid
nanoparticles
smart
nanogels).
third
part,
advantages
discussed,
finally,
market
research
commercial
used
nanotechnological
approaches
was
included.
