Nanocurcumin: A Promising Candidate for Therapeutic Applications

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: May 1, 2020

Curcuma longa is an important medicinal plant and a spice in Asia. Curcumin (diferuloylmethane) hydrophobic bioactive ingredient found rhizome of the C. longa. It has drawn immense attention recent years for its variety biological pharmacological action. However, low water solubility, poor bioavailability, rapid metabolism represent major drawbacks successful therapeutic applications. Hence, researchers have attempted to enhance activity curcumin overcome by efficient delivery systems, particularly nanoencapsulation. Research efforts so far data from available literature shown satisfactory potential nano range formulations (Nanocurcumin), it increases all benefits curcumin, which was not significantly possible earlier. For synthesis nanocurcumin, array techniques been developed each technique own advantages individual characteristics. The two most popular effective are ionic gelation antisolvent precipitation. So far, many nanoformulations delivery, thereby overcoming effects. nanoformulation remained at concept level evidence, thus, several questions challenges still exist recommend nanocurcumin as promising candidate In this review, we discuss on different implications applications well status ongoing clinical trials patents. We also research gap future directions needed propose candidate.

Language: Английский

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Curcumin and colorectal cancer: An update and current perspective on this natural medicine

Seminars in Cancer Biology, Journal Year: 2020, Volume and Issue: 80, P. 73 - 86

Published: Feb. 21, 2020

Language: Английский

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Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Nutrients, Journal Year: 2020, Volume and Issue: 12(9), P. 2499 - 2499

Published: Aug. 19, 2020

Curcumin, a lipophilic polyphenol contained in the rhizome of Curcuma longa (turmeric), has been used for centuries traditional Asian medicine, and nowadays it is widely food as dietary spice worldwide. It received considerable attention its pharmacological activities, which appear to act primarily through anti-inflammatory antioxidant mechanisms. For this reason, proposed tool management many diseases, among are gastrointestinal neurological diabetes, several types cancer. However, pharmacology curcumin remains be elucidated; indeed, discrepancy exists between well-documented vitro vivo activities poor bioavailability chemical instability that should limit any therapeutic effect. Recently, hypothesized could exert direct regulative effects tract, where high concentrations have detected after oral administration. Consequently, might directly exerts regulatory on gut microbiota, thus explaining paradox low systemic wide activities. well known microbiota important roles human physiology, composition can influenced by multitude environmental lifestyle factors. Accordingly, perturbations microbiome profile or dysbiosis key role disease progression. Interestingly, metabolites shown influence microbiota. worth noting from interaction two different phenomena arise: regulation intestinal microflora biotransformation both them potentially crucial activity. This review summarizes most recent studies topic, highlighting strong connection with final aim adding new insight into potential mechanisms effects.

Language: Английский

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Colorectal liver metastasis: molecular mechanism and interventional therapy

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: March 4, 2022

Abstract Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which major cause death. Despite significant advances in diagnostic and therapeutic techniques, survival rate colorectal metastasis (CRLM) remains very low. CRLM, as complex cascade reaction process involving multiple factors procedures, has diverse molecular mechanisms. In this review, we summarize mechanisms/pathophysiology, diagnosis, treatment CRLM. We also focus on an overview recent understanding basis CRLM special emphasis tumor microenvironment promise newer targeted therapies for further improving prognosis patients.

Language: Английский

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JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: March 24, 2022

JAK/STAT signaling pathway is one of the important regulatory cascades for myriad cellular processes initiated by various types ligands such as growth factors, hormones, and cytokines. The physiological regulated are immune regulation, cell proliferation, survival, apoptosis hematopoiesis myeloid non-myeloid cells. Dysregulation reported in immunological disorders, hematological other solid malignancies through oncogenic activation mutations receptors, downstream mediators, associated transcriptional factors STATs. STATs typically have a dual role when explored context cancer. While several members STAT family involved malignancies, however, few which include STAT3 STAT5 linked to tumor initiation progression. Other STAT1 STAT2 pivotal antitumor defense maintenance an effective long-term response evolutionarily conserved programs. effects persistent survival; proliferation invasion made ideal target drug development cancer therapy. Therefore, understanding intricate pathogenesis needs extensive research. A better functionally redundant roles JAKs may provide rationale improving existing therapies deleterious on normal cells identifying novel targets therapeutic intervention malignancies.

Language: Английский

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The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders

Molecules, Journal Year: 2021, Volume and Issue: 26(23), P. 7109 - 7109

Published: Nov. 24, 2021

Curcumin is the primary polyphenol in turmeric's curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but poor solubility low bioavailability. Objective: To improve curcumin's bioavailability, plasma concentration, cellular permeability processes. The nanocurcumin approach over curcumin been proven appropriate for encapsulating or loading (nanocurcumin) to increase its potential. Conclusion: Though incorporating into form may be viable method overcoming intrinsic limitations, there are reasonable concerns regarding toxicological safety once it enters biological pathways. This review article mainly highlights benefits curcumin.

Language: Английский

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Versatile role of curcumin and its derivatives in lung cancer therapy

Journal of Cellular Physiology, Journal Year: 2020, Volume and Issue: 235(12), P. 9241 - 9268

Published: June 9, 2020

Abstract Lung cancer is a main cause of death all over the world with high incidence rate. Metastasis into neighboring and distant tissues as well resistance cells to chemotherapy demand novel strategies in lung therapy. Curcumin naturally occurring nutraceutical compound derived from Curcuma longa (turmeric) that has great pharmacological effects, such anti‐inflammatory, neuroprotective, antidiabetic. The excellent antitumor activity curcumin led its extensive application treatment various cancers. In present review, we describe against cancer. affects different molecular pathways vascular endothelial growth factors, nuclear factor‐κB (NF‐κB), mammalian target rapamycin, PI3/Akt, microRNAs, long noncoding RNAs also can induce autophagy, apoptosis, cell cycle arrest reduce viability proliferation cells. Notably, supplementation sensitizes enhances chemotherapy‐mediated apoptosis. elevate efficacy radiotherapy therapy by targeting signaling pathways, epidermal factor receptor NF‐κB. Curcumin‐loaded nanocarriers enhance bioavailability, cellular uptake, curcumin. aforementioned effects are comprehensively discussed current review further direct studies for applying

Language: Английский

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Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer

Nutrients, Journal Year: 2020, Volume and Issue: 12(3), P. 679 - 679

Published: March 2, 2020

Prostate cancer (PCa) is a heterogeneous disease and ranked as the second leading cause of cancer-related deaths in males worldwide. The global burden PCa keeps rising regardless emerging cutting-edge technologies for treatment drug designation. There are number options which effectively treating localised androgen-dependent (ADPC) through hormonal surgery treatments. However, over time, these cancerous cells progress to androgen-independent (AIPC) continuously grow despite hormone depletion. At this particular stage, androgen depletion therapy (ADT) no longer effective rendered hormone-insensitive capable growing absence androgen. AIPC lethal type leads poor prognosis major contributor death rates. A natural product-derived compound, curcumin has been identified pleiotropic compound influencing modulating diverse range molecular targets signalling pathways order exhibit its medicinal properties. Due such multi-targeted behaviour, benefits paramount combating wide diseases including inflammation disease. Curcumin exhibits anti-cancer properties by suppressing growth survival, inflammation, invasion, cell proliferation well possesses ability induce apoptosis malignant cells. In review, we investigate mechanism multiple receptor (AR) signalling, activating protein-1 (AP-1), phosphatidylinositol 3-kinases/the serine/threonine kinase (PI3K/Akt/mTOR), wingless (Wnt)/ß-catenin nuclear factor kappa-B (NF-κB), B-cell lymphoma 2 (Bcl-2) cyclin D1 implicated development progression both types PCa, ADPC AIPC. addition, role microRNAs clinical trials on effects patients were also reviewed.

Language: Английский

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Curcumin downregulates the PI3K–AKT–mTOR pathway and inhibits growth and progression in head and neck cancer cells

Phytotherapy Research, Journal Year: 2020, Volume and Issue: 34(12), P. 3311 - 3324

Published: July 6, 2020

Abstract Curcumin, a polyphenol isolated from the rhizome of Curcuma longa , has been studied because its antioxidant, antimicrobial, and antiinflammatory properties. This study aimed to evaluate effects curcumin on head neck cancer (HNC) cell lines how it modulates PI3K–AKT–mTOR signaling pathway. Dose‐response curves for were established hypopharynx carcinoma (FaDu), tongue (SCC‐9), keratinocytes (HaCaT) IC 50 values calculated. Cell cycle death investigated through flow cytometry. Cytoskeleton organization was assessed phalloidin+FITC staining. qPCR array western blot performed analyze gene protein expression. Curcumin reduced viability in dose‐dependent selective manner, induced SCC‐9 cells (necrosis/late apoptosis: 44% vs. 16.4% vehicle), arrested at phase G 2 /M FaDu (G : SCC‐9—19.1% 13.4% vehicle; FaDu—37.8% 12.9% vehicle). Disorganized cytoskeleton altered morphology observed. Furthermore, downregulated pathway by modifying expression key genes proteins. These findings highlight promising therapeutic potential inhibit HNC growth progression modulate

Language: Английский

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Co-Delivery of Curcumin and Capsaicin by Dual-Targeting Liposomes for Inhibition of aHSC-Induced Drug Resistance and Metastasis

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(14), P. 16019 - 16035

Published: April 5, 2021

Recent research studies have shown that the low survival rate of liver cancer is due to drug resistance and metastasis. In tumor microenvironment (TME), activated hepatic stellate cells (aHSCs) been proven favor development cancer. Hence, combination therapy dual-targeting aHSCs might be an effective strategy for treatment this study, novel multifunctional liposomes (CAPS-CUR/GA&Gal-Lip) were prepared co-delivery curcumin (CUR) capsaicin (CAPS), in which glycyrrhetinic acid (GA) galactose (Gal) chosen as targeting ligands modify (Lip) To mimic TME, a HSCs+HepG2 (human hepatoma cell line) cocultured model was established antitumor effect vitro. The results showed that, compared HepG2 alone, promoted migration by upregulating expression P-glycoprotein (P-gp) Vimentin, effectively inhibited CAPS-CUR/GA&Gal-Lip. efficacy vivo evaluated three mice models: subcutaneous H22 (mouse tumor-bearing mice, H22+m-HSC cell) orthotopic cells-bearing mice. CAPS-CUR/GA&Gal-Lip exhibited lesser extracellular matrix (ECM) deposition, angiogenesis, superior with no- and/or Gal-modified Lip, attributed simultaneous blocking activation HSCs inhibition metastasis cells. method using Lip thus potential treatment.

Language: Английский

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