Food Emulsifiers and Metabolic Syndrome: The Role of the Gut Microbiota DOI Creative Commons
Martina De Siena, Pauline Raoul, Lara Costantini

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(15), P. 2205 - 2205

Published: July 25, 2022

The use of emulsifiers in processed foods and the rapid epidemic development metabolic syndrome Western countries over past 20 years have generated growing interest. Evidence for role through gut microbiota has not been clearly established, thus making it challenging clinical nutritionists dietitians to make evidence-based associations between nature quantity disorders. This narrative review summarizes highest quality evidence currently available about impact food on composition functions potential syndrome. state-of-the-art different common is performed, highlighting where they are present daily their roles. Recent findings vitro, vivo, human studies assessing effect recently published. There some progress understanding how could contribute developing diseases alterations while others prebiotic effects. However, there still many unanswered questions regarding consumption amounts synergic effects emulsifiers' intake responses by microbial signatures each individual.

Language: Английский

Self-emulsifying drug delivery system: Mucus permeation and innovative quantification technologies DOI
Muthanna Abdulkarim, Peeyush Sharma, Mark Gumbleton

et al.

Advanced Drug Delivery Reviews, Journal Year: 2019, Volume and Issue: 142, P. 62 - 74

Published: March 1, 2019

Language: Английский

Citations

81
Structure and Fate of Nanoparticles Designed for the Nasal Delivery of Poorly Soluble Drugs DOI Creative Commons
Adryana Clementino,

G. Pellegrini,

Sabrina Banella

et al.

Molecular Pharmaceutics, Journal Year: 2021, Volume and Issue: 18(8), P. 3132 - 3146

Published: July 14, 2021

Nanoparticles are promising mediators to enable nasal systemic and brain delivery of active compounds. However, the possibility reaching therapeutically relevant levels exogenous molecules in body is strongly reliant on ability nanoparticles overcome biological barriers. In this work, three paradigmatic nanoformulations vehiculating poorly soluble model drug simvastatin were addressed: (i) hybrid lecithin/chitosan (LCNs), (ii) polymeric poly-ε-caprolactone nanocapsules stabilized with nonionic surfactant polysorbate 80 (PCL_P80), (iii) a polysaccharide-based surfactant, i.e., sodium caproyl hyaluronate (PCL_SCH). The nanosystems investigated for their physicochemical structural properties impact biopharmaceutical aspects critical nose-to-brain delivery: biocompatibility, release, mucoadhesion, permeation across mucosa. All highly reproducible, small particle size (∼200 nm), narrow distribution (polydispersity index (PI) < 0.2), high encapsulation efficiency (>97%). Nanoparticle composition, surface charge, internal structure (multilayered, core–shell or raspberry-like, as assessed by small-angle neutron scattering, SANS) demonstrated have an both drug-release profile and, strikingly, its behavior at interface. interaction mucus layer kinetics extent transport excised animal epithelium modulated nanoparticle surface. fact, all produced improved epithelial barrier cavity compared traditional formulation. Interestingly, however, enhancement was achieved via two distinct pathways: (a) enhanced mucoadhesion LCN accompanied fast mucosal drug, (b) mucopenetration uptake potential whole PCL_P80 PCL_SCH delayed boost correlation between appears be pivotal point development novel platforms suitable pharmaceutical compounds intranasal administration.

Language: Английский

Citations

66
The Role of Carrageenan in Inflammatory Bowel Diseases and Allergic Reactions: Where Do We Stand? DOI Open Access
Barbara Borsani, Raffaella De Santis, Veronica Perico

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(10), P. 3402 - 3402

Published: Sept. 27, 2021

Carrageenan (CGN) is a high molecular weight polysaccharide extracted from red seaweeds, composed of D-galactose residues linked in β-1,4 and α-1,3 galactose-galactose bond, widely used as food additive processed foods for its properties thickener, gelling agent, emulsifier, stabilizer. In recent years, with the spread Western diet (WD), consumption has increased. Nonetheless, there debate on safety. CGN extensively an inflammatory adjuvant agent vitro animal experimental models investigation immune processes or to assess activity anti-inflammatory drugs. can activate innate pathways inflammation, alter gut microbiota composition thickness mucus barrier. Clinical evidence suggests that involved pathogenesis clinical management bowel diseases (IBD), indeed food-exclusion diets be effective therapy disease remission. Moreover, specific IgE oligosaccharide α-Gal been associated allergic reactions commonly referred "α-Gal syndrome". This review aims discuss role carrageenan following current evidence. Furthermore, no definitive data are available safety effects CGN, we suggest gaps filled advise limit human exposure by reducing ultra-processed foods.

Language: Английский

Citations

63
Diet, microbiota, and the mucus layer: The guardians of our health DOI Creative Commons
Francesco Suriano, Elisabeth Nyström, Domenico Sergi

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 13, 2022

The intestinal tract is an ecosystem in which the resident microbiota lives symbiosis with its host. This symbiotic relationship key to maintaining overall health, dietary habits of host representing one main external factors shaping microbiome-host relationship. Diets high fiber and low fat sugars, as opposed Western high-fat diets, have been shown a beneficial effect on health by promoting growth bacteria, improve mucus barrier function immune tolerance, while inhibiting pro-inflammatory responses their downstream effects. On contrary, diets sugars associated alterations composition/functionality subsequent development chronic diseases such food allergies, inflammatory bowel disease, metabolic disease. In this review, we provided updated overview current understanding connection between diet, microbiota, special focus role homeostasis modulating gut microbiota.

Language: Английский

Citations

63
Transient Permeation Enhancer® (TPE®) technology for oral delivery of octreotide: a technological evaluation DOI Creative Commons
David J. Brayden, Sam Maher

Expert Opinion on Drug Delivery, Journal Year: 2021, Volume and Issue: 18(10), P. 1501 - 1512

Published: June 15, 2021

The FDA approval of oral semaglutide for type 2 diabetes (2019) and octreotide acromegaly (2020) is evidence that selected niche peptides can be administered orally if formulated with intestinal permeation enhancers.We evaluated the formulation, MYCAPSSA® (Chiasma Pharmaceuticals, Needham, MA, USA). An outline current standard care in benefits versus depot injections provided. We discuss Transient Permeation Enhancer (TPE®) technology used detail safety efficacy data from animal models clinical trials.TPE® an oily suspension includes a number excipients transiently alter epithelial barrier integrity by opening tight junctions arising transcellular perturbation. Phase I studies using 20 mg capsules yielded relative bioavailability ~0.7% primary endpoints were achieved two III studies. dose required to achieve these was over 200 times 0.1 immediate-release subcutaneous injection, reminder difficulty achieving absorption macromolecules. Many patients will prefer convenient twice-daily formulation compared monthly injections.

Language: Английский

Citations

59
The Future of Precision Medicine to Predict Outcomes and Control Tissue Remodeling in Inflammatory Bowel Disease DOI
Christopher A Lamb, Aamir Saifuddin, Nick Powell

et al.

Gastroenterology, Journal Year: 2022, Volume and Issue: 162(5), P. 1525 - 1542

Published: Jan. 4, 2022

Language: Английский

Citations

48
Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80 DOI Creative Commons
İsmail Öğülür, Duygu Yazıcı, Yağız Pat

et al.

Allergy, Journal Year: 2023, Volume and Issue: 78(9), P. 2441 - 2455

Published: Aug. 2, 2023

The rising prevalence of many chronic diseases related to gut barrier dysfunction coincides with the increased global usage dietary emulsifiers in recent decades. We therefore investigated effect frequently used food on cytotoxicity, function, transcriptome alterations, and protein expression gastrointestinal epithelial cells.Human intestinal organoids originating from induced pluripotent stem cells, colon organoid organ-on-a-chip, liquid-liquid interface cells were cultured presence two common emulsifiers: polysorbate 20 (P20) 80 (P80). transepithelial electrical resistance (TEER), paracellular-flux measured. Immunofluorescence staining tight-junctions (TJ), RNA-seq transcriptome, targeted proteomics performed.Cells showed lysis response P20 P80 exposure starting at a 0.1% (v/v) concentration across all models. Epithelial disruption correlated decreased TEER, irregular TJ immunostaining. analyses demonstrated upregulation cell development, signaling, proliferation, apoptosis, inflammatory response, stress 0.05%, lower than direct toxicity. A proinflammatory was characterized by secretion several cytokines chemokines, interaction their receptors, PI3K-Akt MAPK signaling pathways. CXCL5, CXCL10, VEGFA upregulated CXCL1, CXCL8 (IL-8), LIF P80.The present study provides evidence detrimental effects integrity. underlying mechanism death concentrations between 1% 0.1%. Even 0.1%, these polysorbates suggesting health.

Language: Английский

Citations

38
Food additive emulsifiers and risk of cardiovascular disease in the NutriNet-Santé cohort: prospective cohort study DOI Creative Commons
Laury Sellem, Bernard Srour,

Guillaume Javaux

et al.

BMJ, Journal Year: 2023, Volume and Issue: unknown, P. e076058 - e076058

Published: Sept. 6, 2023

Abstract Objective To assess the associations between exposure to food additive emulsifiers and risk of cardiovascular disease (CVD). Design Prospective cohort study. Setting French NutriNet-Santé study, 2009-21. Participants 95 442 adults (>18 years) without prevalent CVD who completed at least three 24 hour dietary records during first two years follow-up. Main outcome measures Associations intake (continuous (mg/day)) CVD, coronary heart disease, cerebrovascular characterised using multivariable proportional hazard Cox models compute ratios for each additional standard deviation (SD) emulsifier intake, along with 95% confidence intervals. Results Mean age was 43.1 (SD 14.5) years, 79.0% (n=75 390) participants were women. During follow-up (median 7.4 years), 1995 incident 1044 974 events diagnosed. Higher celluloses (E460-E468) found be positively associated higher risks (hazard ratio an increase 1 1.05, interval 1.02 1.09, P=0.003) (1.07, 1.12, P=0.004). Specifically, cellulose E460 linked (1.05, 1.01 P=0.007) P=0.005), carboxymethylcellulose (E466) (1.03, P=0.004) (1.04, 1.06, P=0.001). Additionally, intakes monoglycerides diglycerides fatty acids (E471 E472) all outcomes. Among these emulsifiers, lactic ester (E472b) (1.06, 1.10, P=0.002) (1.11, 1.06 1.16, P<0.001), citric acid (E472c) 1.07, 1.03 P<0.001). High trisodium phosphate (E339) increased 1.00 P=0.03). Sensitivity analyses showed consistent associations. Conclusion This study positive five individual groups widely used in industrial foods. Trial registration ClinicalTrials.gov NCT03335644 .

Language: Английский

Citations

25
Safety of surfactant excipients in oral drug formulations DOI Creative Commons
Sam Maher, Caroline Geoghegan, David J. Brayden

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 202, P. 115086 - 115086

Published: Sept. 21, 2023

Surfactants are a diverse group of compounds that share the capacity to adsorb at boundary between distinct phases matter. They used as pharmaceutical excipients, food additives, emulsifiers in cosmetics, and household/industrial detergents. This review outlines interaction surfactant-type excipients present oral dosage forms with intestinal epithelium gastrointestinal (GI) tract. Many surfactants permitted for human consumption products reduce epithelial cell viability vitro alter barrier integrity monolayers, isolated GI tissue mucosae, animal models. suggests degree mis-match predicting safety issues humans from such Recent controversial preclinical research also infers some widely may be linked ulcerative colitis, metabolic disorders, cancers. We wide range surfactant regarding their interactions Safety data is reviewed across vitro, ex vivo, pre-clinical animal, studies. The factors mitigate against potentially abrasive effects on epithelia observed studies summarised. conclude perspective overall forms, which has relevance delivery system development.

Language: Английский

Citations

25
Impact of ultra‐processed meat products on human health: Review and outlook DOI Open Access
Dan Yang,

Chengpu Chen,

Di Zhao

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(2)

Published: Feb. 1, 2025

Abstract Modern diets are increasingly dominated by ultra‐processed foods, a shift driven urbanization and lifestyle changes. Among these, meat products (UPMPs) particularly popular due to their appealing flavor texture. However, emerging evidence highlights potential health risks associated with UPMPs. Although rich in high‐quality proteins, the processing methods used UPMPs can affect protein digestibility. Moderate techniques, such as sous‐vide cooking, fermentation, enzymatic tenderization, enhance digestion nutrient absorption, whereas excessive may lead aggregation cross‐linking, reducing Additionally, overuse of additives thermal key concerns UPMP production, leading formation potentially harmful substances, including acrylamide, heterocyclic amines, polycyclic aromatic hydrocarbons, advanced glycation end products. This review examines how different techniques influence digestibility UPMPs, elucidates pathways through which substances generated, assesses impact on gut health, focus microbiota colon. Our synthesis current research indicates that consumption contributes dysbiosis, compromises barrier, increases risk colorectal cancer, though dose‐dependent effects require further clarification. Future should parameters moderate processing, explore natural alternatives additives, examine dose–response relationship between risks, evaluate individual factors, genetics metabolism, impacts

Language: Английский

Citations

1