Management ofHelicobacter pyloriinfection: the Maastricht VI/Florence consensus report

Gut, Journal Year: 2022, Volume and Issue: 71(9), P. 1724 - 1762

Published: Aug. 8, 2022

Helicobacter pylori Infection is formally recognised as an infectious disease, entity that now included in the International Classification of Diseases 11th Revision. This principle leads to recommendation all infected patients should receive treatment. In context wide clinical spectrum associated with gastritis, specific issues persist and require regular updates for optimised management. The identification distinct scenarios, proper testing adoption effective strategies prevention gastric cancer other complications are addressed. H. treatment challenged by continuously rising antibiotic resistance demands susceptibility consideration novel molecular technologies careful selection first line rescue therapies. role therapies their impact on gut microbiota also considered. Progress made management infection covered present sixth edition Maastricht/Florence 2021 Consensus Report, key aspects related were re-evaluated updated. Forty-one experts from 29 countries representing a global community, examined new data five working groups: (1) indications/associations, (2) diagnosis, (3) treatment, (4) prevention/gastric (5) microbiota. results individual groups presented final consensus voting participants. Recommendations provided basis best available evidence relevance various fields.

Language: Английский

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Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling

Science Signaling, Journal Year: 2022, Volume and Issue: 15(756)

Published: Oct. 18, 2022

The tumor microbiome is increasingly implicated in cancer progression and resistance to chemotherapy. In pancreatic ductal adenocarcinoma (PDAC), high intratumoral loads of Fusobacterium nucleatum correlate with shorter survival patients. Here, we investigated the potential mechanisms underlying this association. We found that F. infection induced both normal epithelial cells PDAC secrete increased amounts cytokines GM-CSF, CXCL1, IL-8, MIP-3α. These proliferation, migration, invasive cell motility infected noninfected but not noncancerous cells, suggesting autocrine paracrine signaling cells. This phenomenon occurred response regardless strain absence immune other stromal Blocking GM-CSF markedly limited proliferative gains after infection. Thus, pancreas elicits cytokine secretion from cancerous promotes phenotypes associated progression. findings support importance exploring host-microbe interactions guide future therapeutic interventions.

Language: Английский

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More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Feb. 3, 2022

Fusobacterium nucleatum is a common oral opportunistic bacterium that can cause different infections. In recent years, studies have shown F. enriched in lesions periodontal diseases, halitosis, dental pulp infection, cancer, and systemic diseases. Hence, it promote the development and/or progression of these conditions. The current study aimed to assess research progress epidemiological evidence, possible pathogenic mechanisms, treatment methods Novel viewpoints obtained provide knowledge about role hosts basis for identifying new diagnosis nucleatum-related

Language: Английский

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Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway

Cancer Letters, Journal Year: 2022, Volume and Issue: 530, P. 59 - 67

Published: Jan. 14, 2022

Language: Английский

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Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance

Cancer Biology & Therapy, Journal Year: 2024, Volume and Issue: 25(1)

Published: Jan. 30, 2024

Fusobacterium nucleatum, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role cancer progression and prognosis. While extensive research revealed mechanistic links between nucleatum colorectal cancer, a comprehensive review spanning presence metastatic implications cancers beyond origin is conspicuously absent. This paper broadens our perspective from to various malignancies associated with including oral, pancreatic, esophageal, breast, gastric cancers. Our central focus unravel mechanisms governing colonization, initiation, promotion of metastasis across diverse types. Additionally, we explore nucleatum's adverse impacts on therapies, particularly within domains immunotherapy chemotherapy. Furthermore, this underscores clinical significance as potential tumor biomarker therapeutic target, offering novel outlook applicability detection prognostic assessment.

Language: Английский

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The dynamic oral–gastric microbial axis connects oral and gastric health: current evidence and disputes

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 2, 2025

Emerging evidence indicates that oral microbes are closely related to gastric and lesions, including atrophy, intestinal metaplasia cancer (GC). Helicobacter pylori is a key pathogen involved in GC. However, the increasing prevalence of H. pylori-negative GC dysbiosis patients emphasize potential role other microbial factors. In this review, we discussed current about relationship between oral–gastric axis health. Epidemiologic poor hygiene greater risk. Multiple oral-associated enriched stomach patients. Once colonizing stomach, Streptococcus anginosus Prevotella melaninogenica, inflammation or carcinogenesis. Microbial metabolites such as lactate, nitrite, acetaldehyde promote malignant transformation. The checkpoint transmission digestive tract, great importance since link diseases has been emphasized. Still, new technologies standardized metrics necessary identify pathogenetic for core microbiota, interactions, richness, colonization, location effect (CIRCLE). future, could be candidates noninvasive indicators predict diseases.

Language: Английский

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Role of the Gastric Microbiome in Gastric Cancer: From Carcinogenesis to Treatment

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: March 15, 2021

The development of sequencing technology has expanded our knowledge the human gastric microbiome, which is now known to play a critical role in maintenance homeostasis, while alterations microbial community composition can promote diseases. Recently, carcinogenic effects microbiome have received increased attention. Gastric cancer (GC) one most common malignancies worldwide with high mortality rate. Helicobacter pylori well-recognized risk factor for GC. More than half global population infected H. , modulate acidity stomach alter profile, leading -associated Moreover, there increasing evidence that bacteria other and their metabolites also contribute carcinogenesis. Therefore, clarifying contribution progression GC lead improvements prevention, diagnosis, treatment. In this review, we discuss current state regarding changes caused by infection, non- GC, as well potential therapeutic infection

Language: Английский

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Chain elongators, friends, and foes

Current Opinion in Biotechnology, Journal Year: 2021, Volume and Issue: 67, P. 99 - 110

Published: Jan. 30, 2021

Language: Английский

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The Role of Microbiota in Gastrointestinal Cancer and Cancer Treatment: Chance or Curse?

Cellular and Molecular Gastroenterology and Hepatology, Journal Year: 2021, Volume and Issue: 13(3), P. 857 - 874

Published: Sept. 8, 2021

The gastrointestinal (GI) tract is home to a complex and dynamic community of microorganisms, comprising bacteria, archaea, viruses, yeast, fungi. It widely accepted that human health shaped by these microbes their collective microbial genome. This so-called second genome plays an important role in normal functioning the host, contributing processes involved metabolism immune modulation. Furthermore, gut microbiota also capable generating energy nutrients (eg, short-chain fatty acids vitamins) are otherwise inaccessible host essential for mucosal barrier homeostasis. In recent years, numerous studies have pointed toward dysbiosis as key driver many GI conditions, including cancers. However, comprehensive mechanistic insights on how collectively influence carcinogenesis remain limited. addition carcinogenesis, now has been shown play influencing clinical outcomes cancer immunotherapy, making them valuable targets treatment cancer. becoming apparent that, besides microbiota's impact therapeutic outcomes, may turn composition. review provides overview cancers, specifically esophageal, gastric, colorectal potential mechanisms implications diagnostics treatment.

Language: Английский

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Microbiota and gastric cancer

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 11 - 17

Published: May 6, 2022

Language: Английский

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