International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 131928 - 131928
Published: April 28, 2024
Language: Английский
Biomedical Microdevices, Journal Year: 2024, Volume and Issue: 26(1)
Published: Jan. 23, 2024
Abstract The rise in drug resistance pathogenic bacteria greatly endangers public health the post-antibiotic era, and drug-resistant currently pose a great challenge not only to community but also clinical procedures, including surgery, stent implantation, organ transplantation, other medical procedures involving any open wound compromised human immunity. Biofilm-associated failure, as well rapid last-resort antibiotics, necessitates search for novel treatments against bacterial infection. In recent years, flourishing development of nanotechnology has provided new insights exploiting promising alternative therapeutics bacteria. Metallic agents have been applied antibacterial usage several centuries, functional modification metal-based biomaterials using now attracted interest field, their intrinsic nature ready on-demand functionalization enhanced interaction with bacteria, rendering them good potential further translation. However, possible toxicity MNPs host cells tissue still hinders its application, current knowledge on cellular pathways is enough. This review will focus advances developing metallic nanoparticles (MNPs), silver, gold, copper, nanoparticles, applications, mechanisms hosts.
Language: Английский
Citations
27
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: July 31, 2024
Nanoparticles play a crucial role in the field of nanotechnology, offering different properties due to their surface area attributed small size. Among them, silver nanoparticles (AgNPs) have attracted significant attention antimicrobial properties, with applications that date back from ancient medicinal practices contemporary commercial products containing ions or nanoparticles. AgNPs possess broad-spectrum biocidal potential against bacteria, fungi, viruses, and Mycobacterium, addition exhibiting synergistic effects when combined certain antibiotics. The mechanisms underlying its action include generation oxygen-reactive species, damage DNA, rupture bacterial cell membranes inhibition protein synthesis. Recent studies highlighted effectiveness various clinically relevant strains through combat antibiotic-resistant pathogens. This review investigates proteomic by which exert effects, special focus on activity planktonic bacteria biofilms. Furthermore, it discusses biomedical non-preparation antibiotic formulations, also addressing issue resistance
Language: Английский
Citations
27
Green Chemistry Letters and Reviews, Journal Year: 2024, Volume and Issue: 17(1)
Published: Feb. 2, 2024
This study aimed to synthesize silver nanoparticles (VJ@AgNPs) using Valeriana jatamansi root extract and assess their antibacterial, antioxidant, antibiofilm properties against Escherichia coli, Staphylococcus aureus, Streptococcus mutans. Various chemical physical characterization methods were employed analyze the synthesized VJ@AgNPs. UV-Visible spectroscopy confirmed presence of VJ@AgNPs with a peak absorption at 426 nm, while FT-IR results indicated involvement phyto-compounds from V. in reduction stabilization these nanoparticles. High-resolution transmission electron microscopy revealed well-dispersed spherical nature an average size 29.1 ± 2.06 X-ray diffraction crystalline structure. The biosynthesized exhibited significant antibacterial activity all tested pathogens, substantial inhibition zones 50 100 μg/mL concentrations. Additionally, displayed potent antioxidant capacity scavenging assays. Furthermore, showed promise photocatalytic degradation, effectively removing 95% RhB dye within 75 minutes under solar light irradiation, following pseudo-first-order kinetics. suggests potential application wastewater treatment for organic removal. biocompatible environmentally friendly underscores as therapeutic agents bacterial infections oxidative stress-related diseases.
Language: Английский
Citations
18
ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 12(7), P. 2719 - 2728
Published: Feb. 1, 2024
How to effectively protect lignin so that it can play a role in the field of food preservation long-term and stable way is problem we need solve. Herein, first, used "armor" prepared by poly(vinyl alcohol) acrylate epoxidized soybean oil comprehensively through emulsion polymerization obtained AS-lignin nanoparticles (NPs). Subsequently, multifunctional NPs/ cellulose acetate (CA) membrane was implanting NPs into CA fiber network via electrostatic spinning technique. The incorporation matrix resulted improved stress transfer from filler, leading significant enhancement its mechanical properties. These membranes possess various properties, such as UV visible light barriers, oxidation resistance, thermal stability, excellent oxygen barrier, water vapor antimicrobial Notably, shelf life fresh apples extended at least 3 days under ambient conditions when they were covered these membranes. be safely degraded natural environment. This means our work introduces novel concept using template develop materials with unique approach holds great promise for creating new generation
Language: Английский
Citations
17
Green Chemistry Letters and Reviews, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 30, 2025
The study explores the green synthesis and characterization of silver nanoparticles using Syzygium malaccense (L.) Merr. & L. M. Perry leaf extract (SM-AgNPs). UV-Visible spectroscopy confirmed reduction ions, showing an absorption peak at 406 nm. X-ray Diffraction (XRD) analysis revealed a face centered cubic structure with average particle size 23.55 Dynamic Light Scattering (DLS) zeta potential analyses indicated mean 40.1 nm surface charge −40.1 mV. FTIR identified functional groups involved in nanoparticle stabilization, while Energy Dispersive (EDX) content. Transmission Electron Microscopy (TEM) Atomic Force (AFM) provided detailed insights into morphology. Anticancer assays showed dose-dependent cytotoxicity against A549 cancer cells (LC50: 7.62 μg mL−1) minimal effects on L-132 normal 73.55 mL−1), highlighting selectivity. Additionally, SM-AgNPs increased Caenorhabditis elegans survival reduced paralysis under pathogenic bacterial exposure. This demonstrates biomedical applications, emphasizing selective anticancer activity antimicrobial vivo.
Language: Английский
Citations
3
Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(2)
Published: April 1, 2025
Language: Английский
Citations
3
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 266 - 266
Published: Feb. 11, 2025
Methicillin-resistant Staphylococcus aureus (MRSA) continues to represent a significant clinical challenge, characterized by consistently elevated rates of morbidity and mortality. Care regimen success is still difficult necessitates assessing new antibiotics as well supplemental services, including source control searching for alternative approaches combating it. Hence, we propose synthesize silver nanoparticles (Ag-NPs) employing cell-free filter (CFF) Streptomyces sp. augment antibiotic activity combat biofilm-forming MRSA. Seven bacterial isolates from samples were identified, profiled with Vitek-2, the phenotypic detecting biofilm Congo red medium microplate assay was carried out. The PCR technique used genes (icaA icaD) coded in forming. characterization Ag-NPs performed using several analytical methods, such UV spectroscopy, dynamic light scattering (DLS), zeta potential measurement, transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR). antibacterial properties oxacillin-Ag-NPs assessed against standard strains agar diffusion microdilution assay. biogenic synthesis resulted uniformly spherical particles, an average size 20 nm. These demonstrated MRSA, minimum inhibitory concentrations (MICs) ranging 12 15 μg/mL. Additionally, completely impede formation MRSA at sublethal doses 0.75 MICs. expression levels icaA icaD reduced 1.9- 2.2- 2.4- 2.8-fold, respectively. A synergistic effect noted when combination oxacillin, leading MICs 1.87 μg/mL oxacillin 4.0 FICi 0.375 further validated relationship between 4 Findings time-kill test highest reduction log10 (CFU)/mL initial inoculum after 12-hour exposure. cytotoxicity analysis revealed no cytotoxic effects on human skin cell line HFB-4 low concentrations, IC50 values 61.40 µg/mL 34.2 HepG-2. Comparable oxacillin-Ag-NPs, showed different exhibited value 31.2 HepG-2-cells. In conclusion, biosynthesis has effective hindered formation, suggesting valuable applications.
Language: Английский
Citations
2
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 1104 - 1104
Published: May 21, 2022
The rapid development of nanotechnology and its applications in medicine has provided the perfect solution against a wide range different microbes, especially antibiotic-resistant ones. In this study, one-step approach was used preparing silver nanoparticles (AgNPs) by mixing nitrate with hot Hypericum perforatum (St. John's wort) aqueous extract under high stirring to prevent agglomeration. formation monitored continuous measurement surface plasma resonance spectra (UV-VIS). effect St. wort on evaluated fully characterized using physicochemical techniques. obtained were spherical, monodisperse, face-centered cubic (fcc) crystal structures, size ranges between 20 40 nm. They covered capping layer organic compounds considered as nano dimension protective that prevents agglomeration sedimentation. AgNPs revealed antibacterial activity both tested Gram-positive Gram-negative bacterial strains causing 13-32 mm inhibition zones MIC 6.25-12.5 µg/mL; Escherichia coli resistant AgNPs. specific growth rate S. aureus significantly reduced due at concentrations ≥½ MIC. did not affect wound migration fibroblast cell lines compared control. Our results highlighted potential use capped plant extracts pharmaceutical food industries control pathogens' growth; however, further studies are required confirm their healing capability health impact must be critically evaluated.
Language: Английский
Citations
44
ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(11), P. 4549 - 4571
Published: Oct. 18, 2023
Silver nanoparticles developed via biosynthesis are the most fascinating nanosized particles and encompassed with excellent physicochemical properties. The bioinspired different shapes sizes have attracted huge attention due to their stability, low cost, environmental friendliness, use of less hazardous chemicals. This is an ideal method for synthesizing a range metal from plants biomolecules. Optical biosensors progressively being fabricated attainment sustainability by using opportunities offered nanotechnology. review focuses mainly on tuning optical properties sensing explore importance applications silver nanoparticles. Further, this deliberates role (Ag NPs) in biomedical, agricultural, environmental, energy applications. Profound insight into antimicrobial these also appreciated. Tailor-made effectuating characteristics can unsurprisingly target tumor cells distribute enwrapped payloads intensively. Existing challenges prospects Ag NPs summarized. expected deliver perceptions about progress next generation outstanding performances various fields promoting sustainable practices fabricating devices.
Language: Английский
Citations
36
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Aug. 23, 2023
The main thrust of this project is the fabrication silver nanoparticles (AgNPs) from electronic waste (PCB board) and applying it on 100% cotton fabric as an antimicrobial agent. nanoparticle formation was done by green synthesis way using aqueous leaf extract Eichhornia crassipes. Furthermore, chitosan also applied to with coating. FTIR SEM tests characterized fabricated nanoparticles, were followed disc diffusion method. analysis showed average particle size 76.91 nm. successful reduction bonding cellulose. Besides, EDX reports confirmed existence AgNPs indicating a strong signal in region. In addition, characteristics uniform deposition nanoparticles. Finally, property tested against gram-positive (Staphylococcus aureus) gram-negative (Escherichia coli) bacteria. result found satisfactory case green-synthesized recycled AgNPs. However, effectiveness not observed be higher than pure study, zone inhibition compared reference antibiotics Ciprofloxacin.
Language: Английский
Citations
23