Selenium-Stimulated Exosomes Enhance Wound Healing by Modulating Inflammation and Angiogenesis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11543 - 11543

Published: Sept. 29, 2022

Mesenchymal stem cell (MSC)-derived exosomes have emerged as an attractive cell-free tool in tissue engineering and regenerative medicine. The current study aimed to examine the anti-inflammatory, pro-angiogenic, wound-repair effects of both selenium-stimulated exosomes, check whether latter had superior wound healing capacity over others. cellular molecular network a paracrine signal, was extensively studied by performing miRNA arrays explore key mediators healing. Selenium is known play critical role enhancing proliferation, multi-potency, anti-inflammatory MSCs. Selenium-stimulated showed significant inhibiting inflammation improving pro-angiogenesis human umbilical vein endothelial cells. Cell growth migration dermal fibroblasts regeneration were more enhanced exosome group than selenium groups, thereby further promoting vivo. Taken together, found augment therapeutic adipose MSC-derived regeneration. We concluded that may be considered vital agent for cell-based therapies.

Language: Английский

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Mechanisms and applications of adipose-derived stem cell-extracellular vesicles in the inflammation of wound healing

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 14, 2023

Wound healing is a sophisticated process consisting of serial phases with overlaps, including hemostasis, inflammation, proliferation, and remodeling. The inflammation response an early that plays crucial role in eliminating microbes clearing damaged cell debris. However, some pathological circumstances, such as diabetes mellitus, ischemia, trauma, deep burn, etc., abnormal can cause impaired wound healing. Adipose-derived stem cells (ADSCs) belong to the mesenchymal (MSC) family exhibit prospective applications tissue regeneration dermatological repairs. ADSC-secreted extracellular vesicles (ADSC-EVs) mimic functions ADSCs without concerns survival, immune response, or ethical issues. Studies have revealed ADSC-EVs inhibit responses accelerate through various mechanisms. Moreover, studies explored modifications cargo components enhance their therapeutic efficacy. Given increasing focusing on potential healing, how they interfere different this has been investigated pieces. In review, we summarized all up-to-date evidence map clearer picture underlying mechanisms response. aiming at were also reviewed provide strategies for future investigators.

Language: Английский

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Optimization of exosome-based cell-free strategies to enhance endogenous cell functions in tissue regeneration

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 171, P. 68 - 84

Published: Sept. 19, 2023

Language: Английский

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Application of mesenchymal stem cell exosomes in the treatment of skin wounds

Smart Materials in Medicine, Journal Year: 2023, Volume and Issue: 4, P. 578 - 589

Published: Jan. 1, 2023

Mesenchymal stem cell exosomes (MSC-Exos) are a type of vesicle with biological function secreted by mesenchymal cells (MSCs). In tissue repair, MSC-Exos more effective than MSCs, and they can be used as cell-free alternative therapy to MSCs. This therapeutic system has stable membrane structure that is coated proteins, miRNAs, mRNA, lncRNA, DNA, other macromolecular active substances. These molecules have powerful effect on regeneration. regulate the target through direct recognition, fusion, secretion communication mediators. Skin wound healing consists mainly blood coagulation, inflammation response, proliferation, remodeling. By regulating four stages healing, effectively reduce inflammation, immune promote enhanced migration angiogenesis remodeling, thus shortening time reducing scar formation. A variety factors, genetic material signaling pathways involved in this process. article reviews efficacy mechanism promoting skin repair.

Language: Английский

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Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: 76, P. 30 - 47

Published: Feb. 2, 2024

Language: Английский

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Mesenchymal Stromal Cells Derived from Dental Tissues: Immunomodulatory Properties and Clinical Potential

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1986 - 1986

Published: Feb. 6, 2024

Mesenchymal stem/stromal cells (MSCs) are multipotent located in different areas of the human body. The oral cavity is considered a potential source MSCs because they have been identified several dental tissues (D-MSCs). Clinical trials which from these sources were used shown that effective and safe as treatments for tissue regeneration. Importantly, immunoregulatory capacity has observed all populations; however, this function may vary among types MSCs. Since property clinical interest cell therapy protocols, it relevant to analyze differences capacity, well mechanisms by each type MSC. Interestingly, D-MSCs most suitable regenerating mineralized region. Furthermore, supported due their adequate proliferation, migration, differentiation. There also evidence application protocols against autoimmune diseases other inflammatory conditions immunosuppressive capacity. Therefore, review, at preclinical level combination with found described, addition description applied.

Language: Английский

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Advances in microRNA from adipose-derived mesenchymal stem cell-derived exosome: focusing on wound healing

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(46), P. 9565 - 9577

Published: Jan. 1, 2022

ADMSC-Exo-miRNAs as therapeutic strategies for wound healing.

Language: Английский

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Regulation of NcRNA-protein binding in diabetic foot

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114361 - 114361

Published: Feb. 6, 2023

Non-coding RNA (ncRNA) is a special type of transcript that makes up more than 90 % the human genome. Although ncRNA typically does not encode proteins, it indirectly controls wide range biological processes, including cellular metabolism, development, proliferation, transcription, and post-transcriptional modification. NcRNAs include small interfering (siRNA), PIWI-interacting (piRNA), tRNA-derived (tsRNA), etc. The most researched these are miRNA, lncRNA, circRNA, which crucial regulators in onset diabetes development associated consequences. ncRNAs indicated above linked to numerous problems by binding diabetic foot (DF), nephropathy, cardiomyopathy, peripheral neuropathy. According recent studies, Mir-146a can control AKAP12 axis promote proliferation migration ulcer (DFU) cells, while lncRNA GAS5 activate HIF1A/VEGF pathway TAF15 DFU wound healing. However, there still many unanswered questions about mechanism action ncRNAs. In this study, we explored new progress ncRNA-protein DF, provide help guidance for application early diagnosis potential targeted intervention DFU.

Language: Английский

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Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Feb. 8, 2024

Vascular dementia (VD) is a prevalent cognitive disorder among the elderly. Its pathological mechanism encompasses neuronal damage, synaptic dysfunction, vascular abnormalities, neuroinflammation, and oxidative stress, others. In recent years, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have garnered significant attention as an emerging therapeutic strategy. Current research indicates that MSC-derived (MSC-EVs) play pivotal role in both diagnosis treatment of VD. Thus, this article delves into advancements MSC-EVs VD, discussing mechanisms by which EVs influence pathophysiological processes These form theoretical foundation for their neuroprotective effect VD treatment. Additionally, highlights potential applications diagnosis. conclusion, present promising innovative strategy With rigorous ongoing innovation, concept can transition practical clinical treatment, providing more effective options patients.

Language: Английский

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Connection between Mesenchymal Stem Cells Therapy and Osteoclasts in Osteoarthritis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(9), P. 4693 - 4693

Published: April 23, 2022

The use of mesenchymal stem cells constitutes a promising therapeutic approach, as it has shown beneficial effects in different pathologies. Numerous vitro, pre-clinical, and, to lesser extent, clinical trials have been published for osteoarthritis. Osteoarthritis is type arthritis that affects diarthritic joints which the most common and studied effect cartilage degradation. Nowadays, known osteoarthritis disease with very powerful inflammatory component subchondral bone rest tissues make up joint. This may induce differentiation osteoclasts, bone-resorbing cells. Subchondral degradation suggested key process pathogenesis However, few studies directly focus on activity contrary what happens other cell types joint, such chondrocytes, synoviocytes, osteoblasts. In this review, we try gather bibliography relation osteoclastogenesis. Although find results, point out need further can support tool osteoclasts their consequences osteoarthritic

Language: Английский

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