The Vaginal Microbiome in Health and Disease—What Role Do Common Intimate Hygiene Practices Play?

Microorganisms, Journal Year: 2023, Volume and Issue: 11(2), P. 298 - 298

Published: Jan. 23, 2023

The vaginal microbiome is a dynamic, sensitive microenvironment. hallmark of ‘healthy’ currently believed to be one dominated by Lactobacillus spp., which acidifies the environment and help protect against invading pathogens. However, ‘normal’ often difficult, if not impossible, characterise given that it varies in response numerous variables, including pregnancy, menstrual cycle, contraceptive use, diet, ethnicity, stress. A Lactobacillus-depleted has been linked variety adverse health outcomes, preterm birth (PTB), bacterial vaginosis (BV), increased risk sexually transmitted infections. latter two these have also associated with feminine intimate hygiene practices, many are practised without any evidence benefits. most extensively studied practice douching, known cause dysbiosis, predisposing women BV, pelvic inflammatory disease, PTB. little impact practices products on microbiome. This review aims outline major factors influencing common infections, as well summarise current research surrounding

Language: Английский

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A comprehensive overview of microbiome data in the light of machine learning applications: categorization, accessibility, and future directions

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 13, 2024

Metagenomics, Metabolomics, and Metaproteomics have significantly advanced our knowledge of microbial communities by providing culture-independent insights into their composition functional potential. However, a critical challenge in this field is the lack standard comprehensive metadata associated with raw data, hindering ability to perform robust data stratifications consider confounding factors. In review, we categorize publicly available microbiome five types: shotgun sequencing, amplicon metatranscriptomic, metabolomic, metaproteomic data. We explore importance for reuse address challenges collecting standardized metadata. also, assess limitations collection existing public repositories metagenomic This review emphasizes vital role interpreting comparing datasets highlights need protocols fully leverage data's Furthermore, future directions implementation Machine Learning (ML) retrieval, offering promising avenues deeper understanding ecological roles. Leveraging these tools will enhance capabilities dynamics diverse ecosystems. Finally, emphasize crucial ML models development.

Language: Английский

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Defining Vaginal Community Dynamics: daily microbiome transitions, the role of menstruation, bacteriophages, and bacterial genes

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Aug. 19, 2024

The composition of the vaginal microbiota during menstrual cycle is dynamic, with some women remaining eu- or dysbiotic and others transitioning between these states. What defines dynamics, whether differences are microbiome-intrinsic mostly driven by host unknown. To address this, we characterized 49 healthy, young metagenomic sequencing daily swabs a cycle. We classified dynamics microbiome assessed impact behavior as well at species, strain, gene, phage levels.

Language: Английский

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Diversity in women and their vaginal microbiota

Trends in Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Abstract

Women's health is essential to global societal and economic wellbeing, yet disparities remain prevalent. The vaginal microbiota plays a critical role in health, with research indicating that reduced levels of core bacteria, such as lactobacilli, are associated conditions like bacterial vaginosis (BV) increased infection susceptibility. Lower lactobacilli reported more frequently women African Latin American descent compared European Asian descent. However, geographical other study inclusion analysis biases influence current research. This opinion highlights the need for comprehensive understanding 'healthy' microbiome. It underscores efforts broaden on microbiome diversity socially relevant contexts, avoiding inappropriate applications terms race ethnicity.

Language: Английский

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In harmony? A scoping review of methods to combine multiple 16S amplicon data sets

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Robust evidence on relationships between the human microbiome and health are critical for understanding improving condition. However, there is little information about methodological approaches to combine analyze multiple data sets. To address this gap, we conducted a scoping review of studies that sequencing from sets understand study objectives, sources selection, feature -table assembly methods, analyses. References were identified through systematic search literature published 2011 2022. Our final included 60 articles. Despite wide-spread use word “meta-analysis,” found only 24 used process select their sets, suggesting meanings term within field. While more than two thirds at least one publicly available source, 19 had request original authors. Most (60%) combined disjoint hypervariable regions. The number regions was not associated with table construction method, but method influenced analytical resolution. results suggest community needs examine terminology analytic combining sets; additional work needed explore impact source bias in studies; invite an independent evaluation methods across

Language: Английский

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Meta-analysis reveals the vaginal microbiome is a better predictor of earlier than later preterm birth

BMC Biology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 25, 2023

Abstract Background High-throughput sequencing measurements of the vaginal microbiome have yielded intriguing potential relationships between and preterm birth (PTB; live prior to 37 weeks gestation). However, results across studies been inconsistent. Results Here, we perform an integrated analysis previously published datasets from 12 cohorts pregnant women whose microbiomes were measured by 16S rRNA gene sequencing. Of 2039 included in our analysis, 586 went on deliver prematurely. Substantial variation these existed their definition birth, characteristics study populations, methodology. Nevertheless, a small group taxa comprised vast majority all cohorts. We trained machine learning (ML) models predict PTB composition microbiome, finding low modest predictive accuracy (0.28–0.79). Predictive was typically lower when ML one dataset predicted another dataset. Earlier (< 32 weeks, < 34 weeks) more predictable than late (34–37 weeks), both within datasets. Integrated differential abundance revealed highly significant negative association L. crispatus that consistent almost studies. The presence (18 out 25) genera associated with higher risk PTB, iners , Prevotella Gardnerella showing particularly associations. Some example discrepancies could be attributed specific methodological differences but not most study-to-study variations relationship birth. Conclusions believe future will benefit focus earlier births improved reporting patient metadata shown influence and/or outcomes.

Language: Английский

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Untangling Associations of Microbiomes of Pregnancy and Preterm Birth

Clinics in Perinatology, Journal Year: 2024, Volume and Issue: 51(2), P. 425 - 439

Published: March 15, 2024

Language: Английский

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Vaginal Microbiome: Considerations For Reproductive Health

Future Microbiology, Journal Year: 2022, Volume and Issue: 17(18), P. 1501 - 1513

Published: Oct. 31, 2022

The microbial communities are an indispensable part of the human defense system and coexist with humans as symbionts, contributing to metabolic functions immune against pathogens. An ecologically stable vaginal microbiota is dominated by Lactobacillus species, which plays important role in prevention genital infections controlling pH, reducing glycogen lactic acid, stimulating bacteriocins hydrogen peroxide. In contrast, abnormal composition associated increased risk bacterial vaginosis, trichomoniasis, sexually transmitted diseases, preterm labor other birth defects. This diversity affected race, ethnicity, pregnancy, hormonal changes, sexual activities, hygiene practices conditions. present review, we discuss changes community region at different stages a female's life cycle its influence on her reproductive health pathological

Language: Английский

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Microbial Dysbiosis and Male Infertility: Understanding the Impact and Exploring Therapeutic Interventions

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(10), P. 1491 - 1491

Published: Oct. 13, 2023

The human microbiota in the genital tract is pivotal for maintaining fertility, but its disruption can lead to male infertility. This study examines relationship between microbial dysbiosis and infertility, underscoring promise of precision medicine this field. Through a comprehensive review, research indicates signatures associated with such as altered bacterial diversity, dominance pathogenic species, imbalances microbiome. Key mechanisms linking infertility include inflammation, oxidative stress, sperm structural deterioration. Emerging strategies like targeted antimicrobial therapies, probiotics, prebiotics, fecal transplantation have shown potential adjusting enhance fertility. Notably, application medicine, which customizes treatments based on individual profiles specific causes emerges promising approach treatment outcomes. Ultimately, intricately linked embracing personalized rooted principles could be way forward addressing factors.

Language: Английский

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Human Papillomavirus Infection during Pregnancy and Childhood: A Comprehensive Review

Microorganisms, Journal Year: 2022, Volume and Issue: 10(10), P. 1932 - 1932

Published: Sept. 28, 2022

Human papillomavirus (HPV), the most prevalent sexually transmitted disease worldwide, is causative agent for several genital and oropharyngeal cancers a suspected many malignancies. HPV associated with adverse health outcomes during pregnancy. Infants are also at risk of infection via different transmission routes: vertically from an infected mother horizontally through sexual or non-sexual contact individuals. Several manifestations have been identified childhood, ranging common skin infections to severe complications such as juvenile recurrent respiratory papillomatosis. This review aims provide comprehensive overview epidemiology, manifestations, treatment strategies pregnancy childhood. Moreover, we underline role vaccination in preventing complications.

Language: Английский

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