Walnut-Derived Peptide Improves Cognitive Impairment in Colitis Mice Induced by Dextran Sodium Sulfate via the Microbiota–Gut–Brain Axis (MGBA) DOI
Yuan Qi, Xuehang Wang, Yaoxin Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(49), P. 19501 - 19515

Published: Dec. 1, 2023

In this study, we investigated the protective mechanism of walnut-derived peptide LPLLR (LP-5) against cognitive impairment induced in a dextran sodium sulfate (DSS)-induced colitis mouse model, with emphasis on microbiota–gut–brain axis (MGBA). The results revealed that LP-5 could improve learning ability and memory mice mitigate symptoms, including weight loss, bloody stools, colon shortening, histopathological changes. Additionally, protected integrity intestinal barrier by promoting expression tight junction proteins (TJs) while attenuating colonic inflammation suppressing proinflammatory cytokine epithelial cell apoptosis. Western blotting indicated treatment suppressed inflammatory NF-κB/MLCK/MLC signaling pathway activity. Furthermore, ameliorated hippocampal neuron damage blood–brain (BBB) downregulating microglia marker protein Iba-1, increasing TJ expression, restoring deterioration synaptic proteins. Importantly, 16S rRNA sequencing reshaped abundance wide range gut microbiota at phylum genus levels, increased Prevotella Akkermansia associated tryptophan (TRP), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA). These findings suggest maintain BBB integrity, reverse dysbiosis, mice, providing novel insights into alterations microbes potential new which it causes impairment.

Language: Английский

Can microbiota gut-brain axis reverse neurodegenerative disorders in human? DOI
Xingxing Yuan, Serge Yannick Ouédraogo,

Modou Lamin Jammeh

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102664 - 102664

Published: Jan. 1, 2025

Language: Английский

Citations

1
The interplay between gut microbiota composition and dementia DOI

Rad Ghannadzadeh Kermani pour,

Sara Kamali Zounouzi,

Melina Farshbafnadi

et al.

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Recently, researchers have been interested in the potential connection between gut microbiota composition and various neuropsychological disorders. Dementia significantly affects socioeconomics of families. Gut is considered as a probable factor its pathogenesis. Multiple bacterial metabolites such short-chain fatty acids, lipopolysaccharides, neurotransmitters that are responsible for incidence progression dementia can be produced by microbiota. Various species Bifidobacterium breve , Akkermansia muciniphila Streptococcus thermophilus Escherichia coli Blautia hydrogenotrophica etc. implicated pathogenesis dementia. great target imitating or inhibiting their an adjunctive therapy based on role Therefore, some diets prevent decelerate altering composition. Moreover, probiotics modulate increasing beneficial bacteria reducing detrimental species. These therapeutic modalities novel methods probably safe effective. They enhance efficacy traditional medications improve cognitive function.

Language: Английский

Citations

1
Implicative role of cytokines in neuroinflammation mediated AD and associated signaling pathways: Current progress in molecular signaling and therapeutics DOI
Sneha Kumari,

Rishika Dhapola,

Prajjwal Sharma

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102098 - 102098

Published: Oct. 30, 2023

Language: Английский

Citations

16
Oral Microbiome and Alzheimer’s Disease DOI Creative Commons

Jiamin Wan,

Hongkuan Fan

Microorganisms, Journal Year: 2023, Volume and Issue: 11(10), P. 2550 - 2550

Published: Oct. 13, 2023

The accumulation of amyloid-beta plaques in the brain is a central pathological feature Alzheimer’s disease. It believed that amyloid responses may be result host immune response to pathogens both nervous system and peripheral systems. Oral microbial dysbiosis chronic condition affecting more than 50% older adults. Recent studies have linked oral higher Aβ load development disease humans. Moreover, presence an oral-derived predominant microbiome has been identified brains patients with other neurodegenerative diseases. Therefore, this opinion article, we aim provide summary on microbiomes contribute pathogenesis

Language: Английский

Citations

14
Walnut-Derived Peptide Improves Cognitive Impairment in Colitis Mice Induced by Dextran Sodium Sulfate via the Microbiota–Gut–Brain Axis (MGBA) DOI
Yuan Qi, Xuehang Wang, Yaoxin Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(49), P. 19501 - 19515

Published: Dec. 1, 2023

In this study, we investigated the protective mechanism of walnut-derived peptide LPLLR (LP-5) against cognitive impairment induced in a dextran sodium sulfate (DSS)-induced colitis mouse model, with emphasis on microbiota–gut–brain axis (MGBA). The results revealed that LP-5 could improve learning ability and memory mice mitigate symptoms, including weight loss, bloody stools, colon shortening, histopathological changes. Additionally, protected integrity intestinal barrier by promoting expression tight junction proteins (TJs) while attenuating colonic inflammation suppressing proinflammatory cytokine epithelial cell apoptosis. Western blotting indicated treatment suppressed inflammatory NF-κB/MLCK/MLC signaling pathway activity. Furthermore, ameliorated hippocampal neuron damage blood–brain (BBB) downregulating microglia marker protein Iba-1, increasing TJ expression, restoring deterioration synaptic proteins. Importantly, 16S rRNA sequencing reshaped abundance wide range gut microbiota at phylum genus levels, increased Prevotella Akkermansia associated tryptophan (TRP), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA). These findings suggest maintain BBB integrity, reverse dysbiosis, mice, providing novel insights into alterations microbes potential new which it causes impairment.

Language: Английский

Citations

13