Analysis of Oral Microbiota in Elderly Thai Patients with Alzheimer’s Disease and Mild Cognitive Impairment DOI Open Access
Narongrit Sritana,

Atitaya Phungpinij

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(9), P. 1242 - 1242

Published: Sept. 20, 2024

Alzheimer’s disease (AD) is a neurodegenerative that predominantly affects the older adult population. Neuroinflammation may be triggered by migration of oral microbiota composition changes from cavity to brain. However, relationship between and diseases, such as AD, remains poorly understood. Therefore, we conducted comprehensive comparison relative abundance diversity bacterial taxa present in saliva among adults diagnosed with those mild cognitive impairment (MCI), healthy controls. Saliva samples clinical data were collected 10 AD patients, 46 MCI 44 adults. patients had lower Clinical Dementia Rating, Montreal Cognitive Assessment, Mini-mental Status Examination scores, induced microbial diversity, than control groups. Moreover, exhibited significantly higher levels Fusobacteriota Peptostreptococcaceae Veillonella In conclusion, high Fusobacteria at various (i.e., phylum, class, family, genus levels) serve biomarker for AD. The analysis dysbiosis biomarkers valuable identifying individuals risk

Language: Английский

Integrating the milk microbiome signatures in mastitis: milk-omics and functional implications DOI Creative Commons
Rine Christopher Reuben, Cármen Torres

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Jan. 18, 2025

Mammalian milk contains a variety of complex bioactive and nutritional components microorganisms. These microorganisms have diverse compositions functional roles that impact host health disease pathophysiology, especially mastitis. The advent use high throughput omics technologies, including metagenomics, metatranscriptomics, metaproteomics, metametabolomics, as well culturomics in microbiome studies suggest strong relationships between phenotype signatures While single undoubtedly contributed to our current understanding mastitis, they often provide limited information, targeting only biological viewpoint which is insufficient system-wide information necessary for elucidating the footprints molecular mechanisms driving mastitis dysbiosis. Therefore, integrating multi-omics approach research could generate new knowledge, improve structural ecosystem, insights sustainable control management.

Language: Английский

Citations

1
Oral Microbiome Stamp in Alzheimer’s Disease DOI Creative Commons
Argul Issilbayeva, Aiym Kaiyrlykyzy, E. B. Vinogradova

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(3), P. 195 - 195

Published: Feb. 23, 2024

Recent studies have suggested that periodontal disease and alterations in the oral microbiome may be associated with cognitive decline Alzheimer’s (AD) development. Here, we report a case-control study of microbiota diversity AD patients compared to healthy seniors from Central Asia. We characterized bacterial taxonomic composition (n = 64) group 71) using 16S ribosomal RNA sequencing. According our results, has higher microbial diversity, an increase Firmicutes decrease Bacteroidetes group. LEfSe analysis showed specific differences at genus level both groups. A region-based compartment was also performed, were identified, along absence richness on functional side. Noteworthy findings demonstrated periodontitis-associated bacteria Distinct revealed distribution metabolic pathways between two Our confirms is altered AD. However, comprehensive picture complete requires further investigation.

Language: Английский

Citations

6
Non-invasive biomarkers for early diagnosis of Alzheimer’s disease in bodily fluids DOI
E A Kovalenko, E V Makhnovich, A.V. Pervunina

et al.

S S Korsakov Journal of Neurology and Psychiatry, Journal Year: 2025, Volume and Issue: 125(1), P. 8 - 8

Published: Feb. 11, 2025

One of the urgent problems modern health care is Alzheimer’s disease (AD) and its early diagnosis. This due to rapid global spread AD, lack pathogenetic therapy, ability stabilize progression cognitive impairment in stages disease. Currently, only an autopsy can confirm diagnosis AD with 100% reliability, classical laboratory instrumental methods verification are difficult implement routine clinical practice several limitations. That why study new available biomarkers identified human bodily fluids promising for AD. The review addresses problem using markers fluids, which be obtained a non-invasive way. Potential saliva, tear fluid, urine, nasal secretion reviewed, their prognostic values as indicators stage evaluated.

Language: Английский

Citations

0
A near-infrared fluorescent probe for the detection of mitochondrial viscosity and its application in the imaging of Alzheimer’s disease mice brain DOI
Xinghao Li,

Sitong Hang,

Yingyong Hou

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 334, P. 125924 - 125924

Published: Feb. 20, 2025

Language: Английский

Citations

0
A Potential Link Between Oral Microbiota and Female Reproductive Health DOI Creative Commons
Justyna Marcickiewicz, Małgorzata Jamka, Jarosław Walkowiak

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 619 - 619

Published: March 7, 2025

Oral cavity dysbiosis is associated with numerous inflammatory diseases, including diabetes, bowel and periodontal disease. Changes in the oral microenvironment lead to bidirectional interactions between pathogens individual host systems, which may induce systemic inflammation. There increasing evidence linking condition of most common causes female infertility, such as polycystic ovary syndrome endometriosis, well gestational complications, e.g., low birth weight, preterm delivery, miscarriages. This review highlights composition microbiome relation infertility-related disorders, endometriosis syndrome, provides a comprehensive overview current state knowledge on relationship dysbiotic microbiome, pregnancy, its impact reproductive tract.

Language: Английский

Citations

0
The Oral–Gut Microbiome–Brain Axis in Cognition DOI Creative Commons

Noorul Ain Adil,

Christabel Omo-Erigbe,

Hariom Yadav

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 814 - 814

Published: April 3, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss, affecting millions worldwide. Emerging evidence highlights the oral microbiome—a complex ecosystem of bacteria, fungi, viruses, protozoa as significant factor in health. Dysbiosis microbiome contributes to systemic inflammation, disrupts blood–brain barrier, promotes neuroinflammation, processes increasingly implicated pathogenesis AD. This review examines mechanisms linking dysbiosis through oral–brain oral–gut–brain axis. These interconnected pathways enable bidirectional communication between cavity, gut, brain via neural, immune, endocrine signaling. Oral pathogens, such Porphyromonas gingivalis, along with virulence factors, including lipopolysaccharides (LPS) gingipains, contribute while metabolic byproducts, short-chain fatty acids (SCFAs) peptidoglycans, further exacerbate immune activation. Additionally, this explores influence external diet, pH balance, medication use, smoking, alcohol consumption, hygiene, on microbial diversity stability, highlighting their role shaping outcomes. The dynamic interplay gut microbiomes reinforces importance homeostasis preserving neurological interventions, probiotics, prebiotics, dietary modifications, offer promising strategies support function reduce risk diseases, AD, maintaining diverse microbiome. Future longitudinal research needed identify long-term impact cognition.

Language: Английский

Citations

0
Role of Nonalcoholic Fatty Liver Disease in Periodontitis: A Bidirectional Relationship DOI Open Access

Hardika S Vegda,

Bhavin Patel, Gaurav Girdhar

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Nonalcoholic fatty liver disease (NAFLD) and periodontitis share common risk factors such as obesity, insulin resistance (IR), dyslipidemia, which contribute to systemic inflammation. It has been suggested that a bidirectional relationship exists between NAFLD periodontitis, indicating one condition may exacerbate the other. is characterized by excessive fat deposition in associated with low-grade chronic There are several for development of NAFLD, including gender, geriatric community, race, ethnicity, poor sleep quality deprivation, physical activity, nutritional status, dysbiosis gut microbiota, increased oxidative stress, overweight, higher body mass index (BMI), IR, type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS), dyslipidemia (hypercholesterolemia), sarcopenia (decreased skeletal muscle mass). This inflammation can progression impairing immune responses exacerbating inflammatory processes periodontal tissues. Furthermore, individuals often exhibit altered lipid metabolism, affect oral microbiota composition, leading susceptibility disease. Conversely, linked through mechanisms involving stress. Chronic release pro-inflammatory cytokines bacterial toxins into bloodstream, contributing hepatic steatosis. Moreover, periodontitis-induced stress promote accumulation further aggravating NAFLD. The interplay underscores importance comprehensive management strategies targeting both conditions. Lifestyle modifications regular exercise, healthy diet, proper hygiene practices crucial preventing managing these interconnected diseases. Additionally, interdisciplinary collaboration hepatologists periodontists essential optimizing patient care improving outcomes periodontitis.

Language: Английский

Citations

3
From Gut Microbiota to Brain Waves: The Potential of the Microbiome and EEG as Biomarkers for Cognitive Impairment DOI Open Access

Mahathi Krothapalli,

Lauren Buddendorff,

Hariom Yadav

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6678 - 6678

Published: June 18, 2024

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder and leading cause of dementia. Aging significant risk factor for AD, emphasizing the importance early detection since symptoms cannot be reversed once advanced stage reached. Currently, there no established method AD diagnosis. However, emerging evidence suggests that microbiome has an impact on cognitive function. The gut brain communicate bidirectionally through gut–brain axis, with systemic inflammation identified as key connection may contribute to AD. Gut dysbiosis more in individuals compared their cognitively healthy counterparts, increased permeability subsequent inflammation, potentially causing neuroinflammation. Detecting activity traditionally involves invasive expensive methods, but electroencephalography (EEG) poses non-invasive alternative. EEG measures multiple studies indicate distinct patterns Furthermore, mild impairment differ from those suggesting its potential indication This review aims consolidate existing knowledge biomarkers early-stage highlighting current state research avenues further investigation.

Language: Английский

Citations

2
Is gut microbiota of patients with ALS different from that of healthy individuals? DOI Creative Commons
Zerin Özaydın Aksun, Şeyda Erdoğan, Ayşe Kalkancı

et al.

TURKISH JOURNAL OF MEDICAL SCIENCES, Journal Year: 2024, Volume and Issue: 54(3), P. 579 - 587

Published: Jan. 1, 2024

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Several studies have shown that alterations of microbiota increase the risk disorders. We aimed to reveal whether there difference in gut patients with ALS.

Language: Английский

Citations

2
The Association of the Oral Microbiota with Cognitive Functioning in Adolescence DOI Open Access
Oxana Yu. Naumova, Pavel Dobrynin, Galina Khafizova

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(10), P. 1263 - 1263

Published: Sept. 27, 2024

: A growing body of research supports the role microbial communities residing in digestive system host's cognitive functioning. Most these studies have been focused on gut microbiome and its association with clinical phenotypes middle-aged older adults. There is an insufficiency population-based exploring normative functioning particularly oral microbiota.

Language: Английский

Citations

2