Bioactive Potential of Algae and Algae-Derived Compounds: Focus on Anti-Inflammatory, Antimicrobial, and Antioxidant Effects

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4695 - 4695

Published: Oct. 3, 2024

Algae, both micro- and macroalgae, are recognized for their rich repository of bioactive compounds with potential therapeutic applications. These marine organisms produce a variety secondary metabolites that exhibit significant anti-inflammatory, antioxidant, antimicrobial properties, offering promising avenues the development new drugs nutraceuticals. Algae-derived compounds, including polyphenols, carotenoids, lipids, polysaccharides, have demonstrated efficacy in modulating key inflammatory pathways, reducing oxidative stress, inhibiting microbial growth. At molecular level, these influence macrophage activity, suppress production pro-inflammatory cytokines, regulate apoptotic processes. Studies shown algae extracts can inhibit signaling pathways such as NF-κB MAPK, reduce damage by activating Nrf2, offer an alternative to traditional antibiotics combatting bacterial infections. Furthermore, algae’s extends addressing diseases cardiovascular disorders, neurodegenerative conditions, cancer, ongoing research exploring preclinical animal models. The pig model, due its physiological similarities humans, is highlighted particularly suitable validating bioactivities algal vivo. This review underscores need further investigation into specific mechanisms action clinical applications algae-derived biomolecules.

Language: Английский

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Antibacterial, Antifungal, Antiviral Activity, and Mechanisms of Action of Plant Polyphenols

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2502 - 2502

Published: Dec. 4, 2024

This review describes the enhanced classification of polyphenols into flavonoids, lignans, phenolic acids, stilbenes, and tannins. Its focus is natural sources an in-depth discussion their antibacterial, antifungal, antiviral activity. Besides a broad literature overview, this paper contains authors' experimental data according to some daily consumed vegetables such as tomatoes, different varieties onion, garlic, parsley, cayenne pepper probable relation these activities polyphenols. The isolation via conventional ultrasonic, pressurized liquids pulse-field extractions, well methods for detection determination, are interpreted well. main mechanisms by which inhibit growth bacteria, fungi, viruses, protein synthesis, cell membrane destabilization, ROS production induction, in focus. Data on polyphenol concentrations respective MIC or inhibition zone diameters bacterial fungal species suppressing viral replication depicted. toxicity vitro, ex vivo, vivo towards microorganisms human/animal cells, safety applied clinical industrial applications expanded. also characterizes antimicrobial effects chemically synthesized derivatives. Biotechnological advances reported, especially entrapment biocompatible nanoparticles enhance bioavailability efficacy. Polyphenols promising exploring molecules' novel substances paving path effective agents' discovery, taking consideration positives negatives.

Language: Английский

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Antioxidant and Anti-Obesity Properties of Acidic and Alkaline Seaweed Extracts Adjusted to Different pH Levels

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(1), P. 35 - 35

Published: Jan. 12, 2025

This research examined antioxidant and anti-obesity effects of Palmaria palmata extracts obtained through acidic or alkaline treatments subsequent pH adjustments. After two rounds extraction, the were separated from biomass adjusted to different values: for extracts, 3 (no adjustment), 6, 9, 12; 12 3. The findings revealed that extraction medium as well adjustments significantly influenced composition in terms protein content recovery, amino acids, phenolic compounds (p < 0.05). Acidic conditions produced with potent radical scavenging, especially at 6 (IC50 = 0.30 ± 0.04 mg.mL−1), while favored metal chelating, highest Fe2+ chelation 0.65 0.03 mg.mL−1). Moreover, showed inhibitory activities against porcine pancreatic lipase α-amylase, extract 9 showing best properties 5.38 0.34 mg.mL−1 IC50 5.79 α-amylase). However, α-amylase activity was 3.05 0.66 In conclusion, adjusting seaweed notably influences their bioactive properties, likely due changes reactivity interactions such peptides, carbohydrates, polyphenols.

Language: Английский

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Effects of seaweed on blood plasma immunoglobulin concentration, mucosal immunity, small intestine histomorphology, cecal microbial population, and volatile fatty acid profile in broiler chickens

Veterinary World, Journal Year: 2025, Volume and Issue: unknown, P. 508 - 518

Published: Feb. 1, 2025

Background and Aim: Seaweeds, particularly brown seaweed (BS) green (GS), are rich in bioactive compounds that may enhance poultry health productivity. This study evaluates the effects of dietary BS GS on blood plasma immunoglobulin concentrations, mucosal immunity, small intestine histomorphology, cecal microbial populations, volatile fatty acid (VFA) profiles broiler chickens. Materials Methods: A total 504 one-day-old male broilers were randomly assigned to 12 treatments: negative control (basal diet), a positive diet + 100 mg/kg Vitamin E), diets supplemented with at 0.25%, 0.50%, 0.75%, 1.00%, 1.25%. The followed completely randomized design, data analyzed using one-way analysis variance Duncan’s multiple range test (p < 0.05). Results: Broilers fed 1.25% exhibited significantly higher 0.05) (IgA) G (IgG) concentrations. Dietary inclusion upregulated messenger RNA expression interleukin-6, interleukin-10, interferon-gamma, indicating immunomodulatory effects. Jejunal villus height was increased birds during starter period. Birds receiving 0.50% BS, 0.25% GS, Lactobacillus counts, whereas 0.75% reduced Escherichia coli populations. Furthermore, VFA propionic concentrations observed 1.00% as well BS. Conclusion: (0.75%, 1.25%) enhances immune response by increasing IgA IgG levels. Both positively modulate cytokine expression, intestinal morphology, balance, leading improved gut health. results suggest supplementation serve sustainable feed additives performance while reducing reliance synthetic supplements. Future studies should focus identifying responsible for these their broader implications production. Keywords: chickens, health, immunoglobulin, supplementation, nutrition, acids.

Language: Английский

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Extract optimization of Ulva lactuca L. and biological activities of optimized extracts

BMC Biotechnology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 4, 2025

Algae are microscopic or macroscopic organisms that can photosynthesize and found in both freshwater saltwater ecosystems considered one of the cornerstones life. In our study, biological activities extracts produced under extract conditions provided highest activity Ulva lactuca L. were determined. Two different methods, Response Surface Method (RSM) Artificial Neural Network-Genetic Algorithm (ANN-GA) integration used for optimization. this context, optimum determined as 54.940 ˚C temperature, 6.513 h, 42.109 ethanol/water ratio according to RSM method 56.286 7.2793 36.8625 ANN-GA. The antioxidant optimized evaluated by Rel Assay kits, DPPH FRAP methods. Anticholinesterase testing against acetylcholinesterase butyrylcholinesterase enzymes. addition, antiproliferative effects examined A549 lung cancer cell line phenolic compound contents analyzed LC-MS/MS. As a result analyzes, it was seen obtained from recommended ANN-GA exhibited higher activities. Optimized U. have potential terms total value 6.272 ± 0.024 mmol/L. showed strong cytotoxic line. gallic acid, 4-hydroxybenzoic caffeic vanillic syringic quercetin kaempferol algae conditions. detected acid. addition all these properties, has anticholinesterase study. conclusion, attract attention with their well be source treatment management neurological diseases.

Language: Английский

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Potential of Plant-Based Agents as Next-Generation Plant Growth-Promotors and Green Bactericides Against Pseudomonas savastanoi pv. savastanoi

Agronomy, Journal Year: 2025, Volume and Issue: 15(4), P. 819 - 819

Published: March 26, 2025

One of the most persistent and damaging diseases in olive trees is knot disease. This disease caused by an infection Gram-negative phytopathogenic bacterium Pseudomonas savastanoi pv. that notoriously difficult to control. The increasing demand for eco-friendly sustainable agricultural solutions has driven research into plant-based agents. study investigated antibacterial properties essential oils (EOs) their constituents, mill wastewater (OMWW), phenolic compound hydroxytyrosol (HTyr), algae garlic extracts, as well copper-based plant-stimulating commercial products against P. savastanoi, a significant tree pathogen. Antibacterial activity was determined using Kirby–Bauer disc diffusion broth microdilution methods. EOs derived from Thymus vulgaris (thyme) Origanum compactum (oregano), key components thymol carvacrol, exhibited strongest efficacy. Conversely, OMWW, products, extracts showed limited no vitro, with method. While were highly effective regardless testing method, efficacy bacterial growth inhibition strain- concentration-dependent, possibly highlighting some metabolic or genetic variability target pathogen, even though MIC values all tested strains equal. Bacterial membrane disruption consequent leakage metabolites modes action carvacrol oregano EO. Carvacrol also promoted plant lettuce without phytotoxic effects, although minor necrotic lesions observed young leaves at higher concentrations, presenting these agents potential next-generation green bactericides.

Language: Английский

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Mitigating effects of seaweed on gene expression and histological damage in Nile tilapia under acute ammonia stress and bacterial infection

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(4)

Published: April 10, 2025

Language: Английский

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Seaweed-derived mixed extracts exhibit immunomodulatory properties on porcine alveolar macrophages

The Veterinary Journal, Journal Year: 2025, Volume and Issue: unknown, P. 106358 - 106358

Published: April 1, 2025

Antimicrobial resistance is a growing global concern, prompting for antibiotic alternatives in animal production. Seaweed, abundant bioactive compounds with anti-inflammatory properties, offers natural substitute to synthetic compounds. Considering this, the objective of present study was evaluate bioactivity three seaweeds 1:1 combination Ascophyllum nodosum, Palmaria palmata, and Ulva lactuca. Initially, polyphenol, flavonoid, total phlorotannin content seaweed species were assessed through colorimetric assays. Subsequently, first evaluated an inhibition protein precipitation assay then confirmed vitro gene expression assays LPS-stimulated porcine alveolar macrophages (PAMs). The evaluation molecules revealed high TPC (1487.67±40.39 1763.57±69.01mg TAE/100mg sample, respectively), as well TFC (95.68±3.62 126.09±7.34mg CE/100mg sample) TPhC (0.167±0.02 0.23±0.01mg PGE/100mg) AN UL, respectively. inhibiting disclosed that extracts combining two algae (ANUL, ANPP, PPUL) more effective than effect exhibited by each single extract. assessment significant down-regulation IL-1β TNF-α extracts. In contrast, TGF-β showed increasing trend. These findings, along confirmation molecules, highlight algae's potential, making them suitable antibiotics disease prevention livestock sector. Therefore, future research should explore specific validate their efficacy vivo confirm potential use

Language: Английский

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Metabolomic Profiling of Tenebrio molitor Reared on Chestnut Shell-Enriched Substrate Using NMR Spectroscopy

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3757 - 3757

Published: Nov. 24, 2024

The aim of this study was to evaluate the metabolomic profile

Language: Английский

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Mosquito larvicidal and cytotoxic potentials of the different extracts of the aerial part of Blepharis ciliaris (Acanthaceae) against Culex pipiens (Diptera: Culicidae)

Revista Colombiana de Entomología, Journal Year: 2024, Volume and Issue: 50(2)

Published: Dec. 20, 2024

This study explores the larvicidal potential of a hexane extract from Blepharis ciliaris against Culex pipiens mosquitoes, known vector various diseases. The aimed to find an eco-friendly alternative chemical insecticides. Promising results were obtained, with showing significant activity. LC50, LC90, and LC95 values C. determined as 125.53, 190.5, 198.76 µg/mL, respectively. Furthermore, histological observations using light microscope revealed notable changes in midgut structure treated larvae, including degradation microvilli, degeneration, protrusion epithelial cells peritrophic membrane, loss nuclei, irregular microvilli. These findings suggest that B. has natural agent mosquitoes. MTT assay indicate tested extracts did not exhibit cytotoxic effects on Huh-7 cells, no morphological observed under microscopy. this contains bioactive compounds could serve bio-larvicides for controlling vectors. Further research should be conducted assess efficacy botanical insecticide small-scale field trials develop environmentally safe interventions populations.

Language: Английский

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