Metabolic memory: mechanisms and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 28, 2024

Metabolic diseases and their complications impose health economic burdens worldwide. Evidence from past experimental studies clinical trials suggests our body may have the ability to remember metabolic environment, such as hyperglycemia or hyperlipidemia, thus leading chronic inflammatory disorders other even after elimination of these environments. The long-term effects that aberrant metabolism on been summarized memory are found assume a crucial role in states disease. Multiple molecular mechanisms collectively participate management, resulting different cellular alterations well tissue organ dysfunctions, culminating disease progression affecting offspring. elucidation expansion concept provides more comprehensive insight into pathogenic underlying promises be new target detection management. Here, we retrace history relevant research summarize its salient characteristics. We provide detailed discussion by which involved development at molecular, cellular, levels, with emphasis impact epigenetic modulations. Finally, present some pivotal findings arguing favor targeting develop therapeutic strategies for latest reflections consequences implications human diseases.

Language: Английский

---

Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11242 - 11347

Published: Oct. 9, 2024

Biopsy, including tissue and liquid biopsy, offers comprehensive real-time physiological pathological information for disease detection, diagnosis, monitoring. Fluorescent probes are frequently selected to obtain adequate on processes in a rapid minimally invasive manner based their advantages biopsy. However, conventional fluorescent have been found show aggregation-caused quenching (ACQ) properties, impeding greater progresses this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) promoted advancements molecular bionanomaterials owing unique high quantum yield (QY) signal-to-noise ratio (SNR),

Language: Английский

---

Advances in the molecular mechanisms of statins in regulating endothelial nitric oxide bioavailability: Interlocking biology between eNOS activity and L-arginine metabolism

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 171, P. 116192 - 116192

Published: Jan. 22, 2024

Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A, are widely used to treat hypercholesterolemia. In addition, statins have been suggested reduce the risk cardiovascular events owing their pleiotropic effects on vascular system, including vasodilation, anti-inflammation, anti-coagulation, anti-oxidation, and inhibition smooth muscle cell proliferation. The major beneficial effect in maintaining homeostasis is induction nitric oxide (NO) bioavailability by activating endothelial NO synthase (eNOS) cells. mechanisms underlying increased eNOS activation well-established various fields, transcriptional post-transcriptional regulation, kinase-dependent phosphorylation protein-protein interactions. However, mechanism which affect metabolism L-arginine, a precursor biosynthesis, has rarely discussed. Autophagy, crucial for energy homeostasis, regulates functions, production angiogenesis, potential therapeutic target diseases. this review, addition summarizing molecular statins, we also discuss L-arginine.

Language: Английский

---

Assessing the Progression of Early Atherosclerosis Mice Using a Fluorescence Nanosensor for the Simultaneous Detection and Imaging of pH and Phosphorylation

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(3)

Published: Nov. 11, 2022

The inflammatory microenvironment involves changes in pH and protein phosphorylation state is closely related to the occurrence development of atherosclerosis (AS). Herein, we constructed a dual-detection fluorescence nanosensor PCN-NP-HPZ based on post modification MOFs, which realized simultaneous detection imaging through pH-sensitive group piperazine ZrIV node MOFs. sensors were used monitor blood phosphate levels at different time stages during atherosclerotic plaque formation. Two-photon was also performed vascular endothelium. Blood tests combined with two-photon images indicated that early stage AS, tissue lower than normal mice, while higher mice. present study provides new analysis method for assessment disease.

Language: Английский

---

Gender Differences in Insulin Resistance: New Knowledge and Perspectives

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(10), P. 7845 - 7861

Published: Sept. 27, 2023

Insulin resistance is the main mechanism in a whole series of pathological conditions, which are not only metabolic interest but also systemic type. This phenomenon means that body’s cells become less sensitive to hormone insulin, leading higher levels insulin blood. can be found both men and women particular, latter, it mainly after menopause. Premenopause, hormonal fluctuations during menstrual cycle, presence estrogen affect sensitivity. Androgens, such as testosterone, typically contribute resistance. In sexes, different human body types distribution location fat, influencing development diabetes cardiovascular disease. associated with some neurological neurogenerative disorders, polycystic ovary syndrome, atherosclerosis, neoplastic pathologies. A healthy lifestyle, including regular physical activity, balanced diet, self-maintenance, help prevent onset resistance, regardless gender, although habits between greatly implementation preventative guidelines fighting manifestations this disorder. review may shed light on gender differences diseases by placing necessary focus personalized medical management inspiring differentiated therapeutic approaches.

Language: Английский

---

Roles of protein post-translational modifications in glucose and lipid metabolism: mechanisms and perspectives

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: July 6, 2023

Abstract The metabolism of glucose and lipids is essential for energy production in the body, dysregulation metabolic pathways these molecules implicated various acute chronic diseases, such as type 2 diabetes, Alzheimer’s disease, atherosclerosis (AS), obesity, tumor, sepsis. Post-translational modifications (PTMs) proteins, which involve addition or removal covalent functional groups, play a crucial role regulating protein structure, localization function, activity. Common PTMs include phosphorylation, acetylation, ubiquitination, methylation, glycosylation. Emerging evidence indicates that are significant modulating lipid by modifying key enzymes proteins. In this review, we summarize current understanding regulatory mechanisms metabolism, with focus on their involvement disease progression associated aberrant metabolism. Furthermore, discuss future prospects PTMs, highlighting potential gaining deeper insights into related diseases.

Language: Английский

---

Statins—From Fungi to Pharmacy

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 466 - 466

Published: Dec. 29, 2023

Statins have been used in the treatment of hyperlipidemia, both as monotherapy and combination therapy. Natural fermentation processes fungi such Monascus spp., Penicillium Aspergillus terreus, Pleurotus ostreatus given rise to natural statins. Compactin (mevastatin), original naturally occurring statin, is primary biotransformation substrate manufacturing process marketed drugs. are classified into natural, semi-synthetic derivatives statins, synthetic ones. Synthetic statins differ from their structural composition, with only common feature being HMG-CoA-like moiety responsible for suppressing HMG-CoA reductase. do not significantly regarding pleiotropic adverse effects, but characteristics depend on pharmacokinetic parameters chemical properties. This paper focuses describing obtaining detailing pharmacokinetics available divided synthetic, indicating effects.

Language: Английский

---

The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism

Genes & Diseases, Journal Year: 2023, Volume and Issue: 11(4), P. 101122 - 101122

Published: Sept. 21, 2023

In recent years, researchers have become focused on the relationship between lipids and bone metabolism balance. Moreover, many diseases related to lipid disorders, such as nonalcoholic fatty liver disease, atherosclerosis, obesity, menopause, are associated with osteoporotic phenotypes. It has been clinically observed in humans that these disorders promote changes osteoporosis-related indicators mineral density mass. Furthermore, similar phenotype were high-fat high-cholesterol-induced animal models. Abnormal (such increased oxidized elevated plasma cholesterol) affects microenvironment homeostasis via cross-organ communication, promoting differentiation of mesenchymal stem cells adipocytes, inhibiting commitment towards osteoblasts. disturbances affect balance by secretion cytokines receptor activator nuclear factor-kappa B ligand osteoblasts stimulating osteoclasts. Conclusively, this review addresses possible link osteoporosis elucidates potential modulatory mechanisms signaling pathways which We also summarize approaches prospects intervening for treatment.

Language: Английский

---

κ-Carrageenan/konjac glucomannan composite hydrogel-based 3D porcine cultured meat production

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 151, P. 109765 - 109765

Published: Jan. 21, 2024

Language: Английский

---

Neutrophil extracellular traps: a catalyst for atherosclerosis

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 479(12), P. 3213 - 3227

Published: Feb. 24, 2024

Language: Английский

---