Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(2), P. 220 - 220
Published: Jan. 18, 2023
The
central
nervous
system
represents
a
complex
environment
in
which
glioblastoma
adapts
skillfully,
unleashing
series
of
mechanisms
suitable
for
its
efficient
development
and
diffusion.
In
particular,
changes
gene
expression
mutational
events
that
fall
within
the
domain
epigenetics
interact
complexly
with
metabolic
reprogramming
stress
responses
enacted
tumor
microenvironment,
turn
fuel
genomic
instability
by
providing
substrates
DNA
modifications.
aim
this
review
is
to
analyze
interaction
consolidates
several
conditions
confer
state
immunosuppression
immunoevasion,
making
capable
escaping
attack
elimination
immune
cells
therefore
invincible
against
current
therapies.
progressive
knowledge
cellular
underlie
resistance
represents,
fact,
only
weapon
unmask
weak
points
be
exploited
plan
successful
therapeutic
strategies.
Experimental & Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
55(4), P. 706 - 715
Published: April 3, 2023
Abstract
Proliferating
cancer
cells
rely
largely
on
glutamine
for
survival
and
proliferation.
Glutamine
serves
as
a
carbon
source
the
synthesis
of
lipids
metabolites
via
TCA
cycle,
well
nitrogen
amino
acid
nucleotide
synthesis.
To
date,
many
studies
have
explored
role
metabolism
in
cancer,
thereby
providing
scientific
rationale
targeting
treatment.
In
this
review,
we
summarize
mechanism(s)
involved
at
each
step
metabolism,
from
transporters
to
redox
homeostasis,
highlight
areas
that
can
be
exploited
clinical
Furthermore,
discuss
mechanisms
underlying
cell
resistance
agents
target
strategies
overcoming
these
mechanisms.
Finally,
effects
blockade
tumor
microenvironment
explore
maximize
utility
blockers
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: March 11, 2024
Abstract
Diet,
serving
as
a
vital
source
of
nutrients,
exerts
profound
influence
on
human
health
and
disease
progression.
Recently,
dietary
interventions
have
emerged
promising
adjunctive
treatment
strategies
not
only
for
cancer
but
also
neurodegenerative
diseases,
autoimmune
cardiovascular
metabolic
disorders.
These
demonstrated
substantial
potential
in
modulating
metabolism,
trajectory,
therapeutic
responses.
Metabolic
reprogramming
is
hallmark
malignant
progression,
deeper
understanding
this
phenomenon
tumors
its
effects
immune
regulation
significant
challenge
that
impedes
eradication.
Dietary
intake,
key
environmental
factor,
can
tumor
metabolism.
Emerging
evidence
indicates
might
affect
the
nutrient
availability
tumors,
thereby
increasing
efficacy
treatments.
However,
intricate
interplay
between
pathogenesis
other
diseases
complex.
Despite
encouraging
results,
mechanisms
underlying
diet-based
remain
largely
unexplored,
often
resulting
underutilization
management.
In
review,
we
aim
to
illuminate
various
interventions,
including
calorie
restriction,
fasting-mimicking
diet,
ketogenic
protein
restriction
high-salt
high-fat
high-fiber
aforementioned
diseases.
We
explore
multifaceted
impacts
these
encompassing
their
immunomodulatory
effects,
biological
impacts,
molecular
mechanisms.
This
review
offers
valuable
insights
into
application
therapies
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 13, 2024
Abstract
Amino
acid
metabolism
plays
important
roles
in
tumor
biology
and
therapy.
Accumulating
evidence
has
shown
that
amino
acids
contribute
to
tumorigenesis
immunity
by
acting
as
nutrients,
signaling
molecules,
could
also
regulate
gene
transcription
epigenetic
modification.
Therefore,
targeting
will
provide
new
ideas
for
treatment
become
an
therapeutic
approach
after
surgery,
radiotherapy,
chemotherapy.
In
this
review,
we
systematically
summarize
the
recent
progress
of
malignancy
their
interaction
with
signal
pathways
well
effect
on
microenvironment
Collectively,
highlight
potential
application
future
expectation.
Gut,
Journal Year:
2023,
Volume and Issue:
72(11), P. 2051 - 2067
Published: July 17, 2023
Metabolic
biomarkers
are
expected
to
decode
the
phenotype
of
gastric
cancer
(GC)
and
lead
high-performance
blood
tests
towards
GC
diagnosis
prognosis.
We
attempted
develop
diagnostic
prognostic
models
for
based
on
plasma
metabolic
information.We
conducted
a
large-scale,
multicentre
study
comprising
1944
participants
from
7
centres
in
retrospective
cohort
264
prospective
cohort.
Discovery
verification
phases
were
through
machine
learning
Cox
regression
fingerprints
(PMFs)
obtained
by
nanoparticle-enhanced
laser
desorption/ionisation-mass
spectrometry
(NPELDI-MS).
Furthermore,
developed
model
was
validated
both
NPELDI-MS
ultra-performance
liquid
chromatography-MS
(UPLC-MS).We
demonstrated
high
throughput,
desirable
reproducibility
limited
centre-specific
effects
PMFs
NPELDI-MS.
In
cohort,
we
achieved
performance
with
areas
under
curves
(AUCs)
0.862-0.988
discovery
(n=1157
5
centres)
independent
external
dataset
(n=787
another
2
centres),
different
PMFs,
including
neural
network,
ridge
regression,
lasso
support
vector
random
forest.
Further,
panel
consisting
21
metabolites
constructed
identified
AUCs
0.921-0.971
0.907-0.940
dataset,
respectively.
(n=264
centre),
UPLC-MS
applied
detect
validate
panel,
0.855-0.918
0.856-0.916,
Moreover,
prognosis
scoring
system
which
can
effectively
predict
survival
patients.We
GC,
also
contribute
advanced
analysis
diseases,
but
not
GC.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Jan. 22, 2024
Abstract
The
incidence
of
nasopharyngeal
carcinoma
(NPC)
exhibits
significant
variations
across
different
ethnic
groups
and
geographical
regions,
with
Southeast
Asia
North
Africa
being
endemic
areas.
Of
note,
Epstein-Barr
virus
(EBV)
infection
is
closely
associated
almost
all
the
undifferentiated
NPC
cases.
Over
past
three
decades,
radiation
therapy
chemotherapy
have
formed
cornerstone
treatment.
However,
recent
advancements
in
immunotherapy
introduced
a
range
promising
approaches
for
managing
NPC.
In
light
these
developments,
it
has
become
evident
that
deeper
understanding
tumor
microenvironment
(TME)
crucial.
TME
serves
dual
function,
acting
as
promoter
tumorigenesis
while
also
orchestrating
immunosuppression,
thereby
facilitating
cancer
progression
enabling
immune
evasion.
Consequently,
comprehensive
comprehension
its
intricate
involvement
initiation,
progression,
metastasis
imperative
development
effective
anticancer
drugs.
Moreover,
given
complexity
inter-patient
heterogeneity,
personalized
treatment
should
be
designed
to
maximize
therapeutic
efficacy
circumvent
drug
resistance.
This
review
aims
provide
an
in-depth
exploration
within
context
EBV-induced
NPC,
particular
emphasis
on
pivotal
role
regulating
intercellular
communication
shaping
responses.
Additionally,
offers
concise
summary
resistance
mechanisms
potential
strategies
their
reversal,
specifically
relation
chemoradiation
therapy,
targeted
immunotherapy.
Furthermore,
advances
clinical
trials
pertaining
are
discussed.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: June 20, 2024
Abstract
RNA
methylation,
a
prevalent
post-transcriptional
modification,
has
garnered
considerable
attention
in
research
circles.
It
exerts
regulatory
control
over
diverse
biological
functions
by
modulating
splicing,
translation,
transport,
and
stability.
Notably,
studies
have
illuminated
the
substantial
impact
of
methylation
on
tumor
immunity.
The
primary
types
encompass
N6-methyladenosine
(m6A),
5-methylcytosine
(m5C),
N1-methyladenosine
(m1A),
N7-methylguanosine
(m7G),
3-methylcytidine
(m3C).
Compelling
evidence
underscores
involvement
regulating
microenvironment
(TME).
By
affecting
translation
stability
through
"writers",
"erasers"
"readers",
influence
dysregulation
immune
cells
factors.
Consequently,
plays
pivotal
role
immunity
mediating
various
behaviors,
encompassing
proliferation,
invasion,
metastasis,
etc.
In
this
review,
we
discussed
mechanisms
several
methylations,
providing
comprehensive
overview
their
roles
underlying
within
among
immunocytes.
exploring
how
these
modifications
mediate
evasion,
also
examine
potential
applications
immunotherapy.
This
review
aims
to
provide
novel
insights
strategies
for
identifying
targets
advancing
cancer
immunotherapy
efficacy.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: March 8, 2024
Abstract
Glutamine
metabolism
plays
a
pivotal
role
in
cancer
progression,
immune
cell
function,
and
the
modulation
of
tumor
microenvironment.
Dysregulated
glutamine
has
been
implicated
development
responses,
supported
by
mounting
evidence.
Cancer
cells
heavily
rely
on
as
critical
nutrient
for
survival
proliferation,
while
require
activation
proliferation
during
reactions.
This
metabolic
competition
creates
dynamic
tug-of-war
between
cells.
Targeting
transporters
downstream
enzymes
involved
holds
significant
promise
enhancing
anti-tumor
immunity.
A
comprehensive
understanding
intricate
molecular
mechanisms
underlying
this
interplay
is
crucial
developing
innovative
therapeutic
approaches
that
improve
immunity
patient
outcomes.
In
review,
we
provide
overview
recent
advances
unraveling
explore
potential
applications
basic
science
discoveries
clinical
setting.
Further
investigations
into
regulation
are
expected
to
yield
valuable
insights,
paving
way
future
interventions.
Glutamate
and
glutamine
are
the
most
abundant
amino
acids
in
blood
play
a
crucial
role
cell
survival
nervous
system.
Various
transporters
found
mitochondrial
membranes,
such
as
solute
carriers
(SLCs)
superfamily,
responsible
for
maintaining
balance
of
glutamate
synaptic
cleft
within
cells.
This
affects
metabolism
non-essential
acids.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 29, 2024
Cancer,
a
disease
that
modern
medicine
has
not
fully
understood
and
conquered,
with
its
high
incidence
mortality,
deprives
countless
patients
of
health
even
life.
According
to
global
cancer
statistics,
there
were
an
estimated
19.3
million
new
cases
nearly
10
deaths
in
2020,
the
age-standardized
mortality
rates
201.0
100.7
per
100,000,
respectively.
Although
remarkable
advancements
have
been
made
therapeutic
strategies
recently,
overall
prognosis
remains
optimistic.
Consequently,
are
still
many
severe
challenges
be
faced
difficult
problems
solved
therapy
today.
Epigallocatechin
gallate
(EGCG),
natural
polyphenol
extracted
from
tea
leaves,
received
much
attention
for
antitumor
effects.
Accumulating
investigations
confirmed
EGCG
can
inhibit
tumorigenesis
progression
by
triggering
apoptosis,
suppressing
proliferation,
invasion,
migration,
altering
tumor
epigenetic
modification,
overcoming
chemotherapy
resistance.
Nevertheless,
regulatory
roles
biomolecular
mechanisms
immune
microenvironment,
metabolic
immunotherapy
remain
obscure.
In
this
article,
we
summarized
most
recent
updates
about
effects
on
microenvironment
(TME),
reprogramming,
anti-cancer
immunotherapy.
The
results
demonstrated
promote
response
cytotoxic
lymphocytes
dendritic
cells
(DCs),
attenuate
immunosuppression
myeloid-derived
suppressor
(MDSCs)
T
(Tregs),
tumor-promoting
functions
tumor-associated
macrophages
(TAMs),
neutrophils
(TANs),
various
stromal
including
cancer-associated
fibroblasts
(CAFs),
endothelial
(ECs),
stellate
cells,
mesenchymal
stem/stromal
(MSCs).
Additionally,
suppress
multiple
reprogramming
pathways,
glucose
uptake,
aerobic
glycolysis,
glutamine
metabolism,
fatty
acid
anabolism,
nucleotide
synthesis.
Finally,
EGCG,
as
immunomodulator
checkpoint
blockade,
enhance
immunotherapeutic
efficacy
may
promising
candidate
conclusion,
plays
versatile
TME
which
provides
novel
insights
combined
