Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement DOI Creative Commons

Rumiana Tenchov,

Janet M. Sasso, Xinmei Wang

et al.

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 15(1), P. 1 - 30

Published: Dec. 14, 2023

Aging is a dynamic, time-dependent process that characterized by gradual accumulation of cell damage. Continual functional decline in the intrinsic ability living organisms to accurately regulate homeostasis leads increased susceptibility and vulnerability diseases. Many efforts have been put forth understand prevent effects aging. Thus, major cellular molecular hallmarks aging identified, their relationships age-related diseases malfunctions explored. Here, we use data from CAS Content Collection analyze publication landscape recent aging-related research. We review advances knowledge delineate trends research advancements on factors attributes across time geography. also current concepts related molecular, cellular, organismic level, age-associated diseases, with attention brain health, as well biochemical processes associated Major outlined, correlations features are hope this will be helpful for apprehending field mechanisms progression, an effort further solve remaining challenges fulfill its potential.

Language: Английский

Hallmarks of aging: An expanding universe DOI Creative Commons
Carlos López‐Otín, Marı́a A. Blasco, Linda Partridge

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(2), P. 243 - 278

Published: Jan. 1, 2023

Language: Английский

Citations

2817
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments DOI Creative Commons
Jun Guo, Xiuqing Huang, Lin Dou

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 16, 2022

Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue cell functions significant increases the risks of various aging-related diseases, including neurodegenerative cardiovascular metabolic musculoskeletal immune system diseases. Although development modern medicine has promoted human health greatly extended life expectancy, aging society, variety chronic diseases have gradually become most important causes disability death elderly individuals. Current research on focuses elucidating how endogenous exogenous stresses (such as genomic instability, telomere dysfunction, epigenetic alterations, loss proteostasis, compromise autophagy, mitochondrial cellular senescence, stem exhaustion, altered intercellular communication, deregulated nutrient sensing) participate regulation aging. Furthermore, thorough pathogenesis to identify interventions that promote longevity caloric restriction, microbiota transplantation, nutritional intervention) clinical treatment methods for (depletion senescent cells, therapy, antioxidative anti-inflammatory treatments, hormone replacement therapy) could decrease incidence turn healthy longevity.

Language: Английский

Citations

700
The gut microbiome as a modulator of healthy ageing DOI Open Access
Tarini Shankar Ghosh, Fergus Shanahan, Paul W. O’Toole

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 19(9), P. 565 - 584

Published: April 25, 2022

Language: Английский

Citations

428
Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation DOI Creative Commons
Sara Federici,

Sharon Kredo‐Russo,

Rafael Valdés‐Mas

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(16), P. 2879 - 2898.e24

Published: Aug. 1, 2022

Language: Английский

Citations

322
Gut barrier disruption and chronic disease DOI
Jan Martel, Shih-Hsin Chang,

Yun‐Fei Ko

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2022, Volume and Issue: 33(4), P. 247 - 265

Published: Feb. 9, 2022

Language: Английский

Citations

299
Peripheral and central immune system crosstalk in Alzheimer disease — a research prospectus DOI Open Access
Brianne M. Bettcher, Malú G. Tansey, Guillaume Dorothée

et al.

Nature Reviews Neurology, Journal Year: 2021, Volume and Issue: 17(11), P. 689 - 701

Published: Sept. 14, 2021

Language: Английский

Citations

282
Meta-hallmarks of aging and cancer DOI Creative Commons
Carlos López‐Otín, Federico Pietrocola, David Roiz‐Valle

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(1), P. 12 - 35

Published: Jan. 1, 2023

Language: Английский

Citations

274
The landscape of aging DOI Open Access
Yusheng Cai, Wei Song, Jiaming Li

et al.

Science China Life Sciences, Journal Year: 2022, Volume and Issue: 65(12), P. 2354 - 2454

Published: Sept. 2, 2022

Language: Английский

Citations

243
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary DOI Creative Commons
Tomas Schmauck‐Medina,

Adrian Molière,

Sofie Lautrup

et al.

Aging, Journal Year: 2022, Volume and Issue: 14(16), P. 6829 - 6839

Published: Aug. 29, 2022

Aging | doi:10.18632/aging.204248. Tomas Schmauck-Medina, Adrian Molière, Sofie Lautrup, Jianying Zhang, Stefan Chlopicki, Helena Borland Madsen, Shuqin Cao, Casper Soendenbroe, Els Mansell, Mark Bitsch Vestergaard, Zhiquan Li, Yosef Shiloh, Patricia L. Opresko, Jean-Marc Egly, Thomas Kirkwood, Eric Verdin, Vilhelm A. Bohr, Lynne S. Cox, Tinna Stevnsner, Lene Juel Rasmussen, Evandro F. Fang

Language: Английский

Citations

229
Microbiota-derived metabolites as drivers of gut–brain communication DOI Creative Commons
Hany Ahmed, Quentin Leyrolle, Ville Koistinen

et al.

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: July 28, 2022

Alterations in the gut microbiota composition have been associated with a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The microbes transform metabolize dietary- host-derived molecules generating diverse group metabolites local systemic effects. bi-directional communication between brain residing gut, so-called gut–brain axis, consists network immunological, neuronal, endocrine signaling pathways. Although full variety mechanisms crosstalk is yet to be established, existing data demonstrates that single metabolite or its derivatives are likely among key inductors within axis communication. However, more research needed understand molecular underlying how alter functions, examine if different interventional approaches targeting could used prevention treatment neurological disorders, as reviewed herein.Abbreviations:4-EPS 4-ethylphenylsulfate; 5-AVA(B) 5-aminovaleric acid (betaine); Aβ Amyloid beta protein; AhR Aryl hydrocarbon receptor; ASD Autism spectrum disorder; BBB Blood–brain barrier; BDNF Brain-derived neurotrophic factor; CNS Central nervous system; GABA ɣ-aminobutyric acid; GF Germ-free; MIA Maternal immune activation; SCFA Short-chain fatty 3M-4-TMAB 3-methyl-4-(trimethylammonio)butanoate; 4-TMAP 4-(trimethylammonio)pentanoate; TMA(O) Trimethylamine(-N-oxide); TUDCA Tauroursodeoxycholic ZO Zonula occludens proteins

Language: Английский

Citations

202