British Journal of Cancer,
Journal Year:
2021,
Volume and Issue:
124(9), P. 1491 - 1502
Published: March 17, 2021
Abstract
Most
cancer
deaths
are
caused
by
metastasis:
recurrence
of
disease
disseminated
tumour
cells
at
sites
distant
from
the
primary
tumour.
Large
numbers
released
tumour,
even
during
early
stages
growth.
However,
only
a
minority
survive
as
potential
seeds
for
future
metastatic
outgrowths.
These
must
adapt
to
relatively
inhospitable
microenvironment,
evade
immune
surveillance
and
progress
micro-
macro-metastatic
stage
generate
secondary
A
pervasive
driver
this
transition
is
chronic
inflammatory
signalling
emanating
themselves.
signals
can
promote
migration
engagement
stem
progenitor
cell
function,
events
that
also
central
wound
healing
response.
In
review,
we
revisit
concept
non-healing
wound,
first
introduced
Virchow
in
19th
century,
with
new
cell-intrinsic
perspective
on
inflammation
focus
metastasis.
Cellular
responses
both
metastasis
tightly
regulated
crosstalk
surrounding
microenvironment.
Targeting
or
restoring
canonical
could
represent
novel
strategy
prevent
lethal
spread
cancer.
Signal Transduction and Targeted Therapy,
Journal Year:
2020,
Volume and Issue:
5(1)
Published: March 12, 2020
Abstract
Metastasis
is
the
hallmark
of
cancer
that
responsible
for
greatest
number
cancer-related
deaths.
Yet,
it
remains
poorly
understood.
The
continuous
evolution
biology
research
and
emergence
new
paradigms
in
study
metastasis
have
revealed
some
molecular
underpinnings
this
dissemination
process.
invading
tumor
cell,
on
its
way
to
target
site,
interacts
with
other
proteins
cells.
Recognition
these
interactions
improved
understanding
biological
principles
metastatic
cell
govern
mobility
plasticity.
Communication
microenvironment
allows
cells
overcome
stromal
challenges,
settle,
colonize.
These
characteristics
are
driven
by
genetic
epigenetic
modifications
within
itself
microenvironment.
Establishing
mechanisms
process
crucial
finding
open
therapeutic
windows
successful
interventions.
In
review,
authors
explore
recent
advancements
field
highlight
latest
insights
contribute
shaping
cancer.
Cancer Discovery,
Journal Year:
2021,
Volume and Issue:
11(4), P. 971 - 994
Published: April 1, 2021
Abstract
Metastasis
is
initiated
and
sustained
through
therapy
by
cancer
cells
with
stem-like
immune-evasive
properties,
termed
metastasis-initiating
(MIC).
Recent
progress
suggests
that
MICs
result
from
the
adoption
of
a
normal
regenerative
progenitor
phenotype
malignant
cells,
intrinsic
programs
to
survive
stresses
metastatic
process,
undergo
epithelial–mesenchymal
transitions,
enter
slow-cycling
states
for
dormancy,
evade
immune
surveillance,
establish
supportive
interactions
organ-specific
niches,
co-opt
systemic
factors
growth
recurrence
after
therapy.
Mechanistic
understanding
molecular
mediators
MIC
phenotypes
host
tissue
ecosystems
could
yield
therapeutics
improve
patient
outcomes.
Significance:
Understanding
origins,
traits,
vulnerabilities
capacity
initiate
metastasis
in
distant
organs,
microenvironments
support
ability
these
surveillance
regenerate
tumor,
critical
developing
strategies
prevention
treatment
advanced
cancer.
Leveraging
recent
our
here
we
review
nature
their
offer
perspective
on
how
this
knowledge
informing
innovative
treatments
cancers.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: March 4, 2022
Abstract
Colorectal
cancer
(CRC)
is
one
of
the
most
frequently
occurring
malignancy
tumors
with
a
high
morbidity
additionally,
CRC
patients
may
develop
liver
metastasis,
which
major
cause
death.
Despite
significant
advances
in
diagnostic
and
therapeutic
techniques,
survival
rate
colorectal
metastasis
(CRLM)
remains
very
low.
CRLM,
as
complex
cascade
reaction
process
involving
multiple
factors
procedures,
has
diverse
molecular
mechanisms.
In
this
review,
we
summarize
mechanisms/pathophysiology,
diagnosis,
treatment
CRLM.
We
also
focus
on
an
overview
recent
understanding
basis
CRLM
special
emphasis
tumor
microenvironment
promise
newer
targeted
therapies
for
further
improving
prognosis
patients.
