Impact of Diabetic Retinopathy on Sleep, Mood, and Quality of Life

Investigative Ophthalmology & Visual Science, Journal Year: 2019, Volume and Issue: 60(6), P. 2304 - 2304

Published: May 1, 2019

Purpose: Diabetic retinopathy (DR) is associated with retinal neuronal and vascular damage. DR has previously been shown to affect the photosensitive ganglion cells (pRGCs). PRGCs are essential for entrainment of circadian rhythms; thus, progression could lead worsening sleep quality mood. We investigate relationship between increasing severity, its impact on Methods: A total 430 participants DR, 303 healthy controls no ocular disease or preexisting disorders were recruited. severity was grouped as follows: 1, mild nonproliferative (NPDR); 2, moderate/severe NPDR; 3, proliferative diabetic (PDR). Sleep, mood, life assessed using Pittsburgh Sleep Quality Index (PSQI), (SF-36), Hospital Anxiety Depression Score (HADS) questionnaires. Data analyzed by correlated sleep, QOL, mood compared controls. Results: No significant difference PSQI scores in group control identified despite DR. Mean anxiety depression within normal range both groups. Despite a lower general health physical function, had than Conclusions: These data show that even severe similar However, this be explained majority individuals study having good visual acuities better eye residual population pRGCs remaining unaffected

Language: Английский

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Objective Measurement of Local Rod and Cone Function Using Gaze-Controlled Chromatic Pupil Campimetry in Healthy Subjects

Translational Vision Science & Technology, Journal Year: 2019, Volume and Issue: 8(6), P. 19 - 19

Published: Nov. 20, 2019

We introduce a new approach for functional mapping of rod and cone activity by measuring pupillary responses to local stimulation via gaze-controlled chromatic pupil campimetry (CPC).Pupillary constriction amplitude latency onset photopic scotopic light stimuli at different locations within the 30° central visual field were analyzed in 14 healthy subjects (4 males, 34 ± 11 years, mean standard deviation [SD]). All measured twice evaluating test-retest variability reproducibility method.For cone-favoring protocol (ConeProt), relative maximal was most pronounced center (26.8% 6.3%) with hill-shaped decrease from fovea periphery. For rod-favoring (RodProt), it smaller (center, 13.5% 4.5%) profile lacking peak. Mean faster cones (277 25 ms) than rods (372 13 ms). intraclass correlation stimulus 0.84 0.08 RodProt 0.75 0.11 ConeProt; coefficients repeatability value all 5.9% 1.2% 8.6% 1.7%, respectively.CPC provides an objective evaluation function field. It shows photoreceptor-specific subjects. Due its easy, noncontact, character, is clinically applicable method may fill gap diagnostics human retina.Chromatic information about retina distinct pattern distributions manner.

Language: Английский

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Relationship between Intrinsically Photosensitive Ganglion Cell Function and Circadian Regulation in Diabetic Retinopathy

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Jan. 31, 2020

Intrinsically photosensitive retinal ganglion cells (ipRGCs) control non-visual light responses (e.g. pupillary reflex and circadian entrainment). Patients with diabetic retinopathy (DR) show reduced ipRGC function, as inferred by abnormalities in the post illumination pupil response (PIPR). We explored whether function DR is associated outputs sleep/wake behavior.Forty-five participants (15 without diabetes, 15 type 2 diabetes (T2D) no DR, T2D DR) participated. was from PIPR (pupil size following stimulus offset). Circadian were melatonin amplitude (overnight urinary 6-sulfatoxymelatonin (aMT6s)) timing (dim onset (DLMO)), evening salivary cortisol levels. Sleep/wake patterns measured wrist actigraphy insomnia symptoms assessed subjectively.Patients had smaller lower aMT6s than other groups (p < 0.001). In adjusted regression models, (β = 4.552, p 0.005). more likely to have detectable DLMO 0.049), higher cortisol, greater sleep variability compared groups. Sleep duration, efficiency rest-activity rhythms similar.Reduced dysregulation disturbances, although a causal relationship cannot be established this cross-sectional study. Prospective mechanistic intervention studies examining health these patients are warranted.

Language: Английский

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Pupillometry via smartphone for low-resource settings

Journal of Applied Biomedicine, Journal Year: 2021, Volume and Issue: 41(3), P. 891 - 902

Published: June 8, 2021

Abstract The photopupillary reflex regulates the pupil reaction to changing light conditions. Being controlled by autonomic nervous system, it is a proxy for brain trauma and conditions of patients in critical care. A prompt evaluation traumas can save lives. With simple penlight, skilled clinicians do that, whereas less specialized ones have resort digital pupilometer. However, many low-income countries lack both pupilometers. This paper presents early results our study aiming at designing, prototyping validating an app testing via Android, following European Medical Device Regulation and relevant standards. After manual validation, prototype underwent technical validation against commercial Infrared As result, proposed performed as well measurements better than solution, with lower errors, higher significant correlations, significantly Bland-Altman plots all pupillometry-related measures. design this medical device was based on expertise low-resource settings. kind environments imposes more stringent criteria due to contextual challenges, including clinicians, funds, spare parts consumables, poor maintenance, harsh environmental conditions, which may hinder safe operationalization devices. provides overview how these unique contextual characteristics are cascaded into order contribute Sustainable Development Goal 3 World Health Organization: Good health well-being.

Language: Английский

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<p>A Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models</p>

Clinical ophthalmology, Journal Year: 2020, Volume and Issue: Volume 14, P. 3285 - 3296

Published: Oct. 1, 2020

Diabetic retinopathy (DR) is a microvascular complication of diabetes with prevalence ~35%, and one the leading causes visual impairment in people working age most developed countries. The earliest stage DR, non-proliferative DR (NPDR), may progress to sight-threatening (STDR). Thus, early detection active regular screening patients are necessary for earlier intervention prevent sight loss. While some countries offer systematic screening, nations reliant on opportunistic or do not any owing limited healthcare resources infrastructure. Currently, retinal imaging approaches include those without mydriasis, single multiple fields, use conventional ultra-wide-field imaging. Advances telescreening automated facilitate previously hard-to-reach communities. Despite heterogeneity fit local needs, an evidence base must be created each model inform practice. In this review, we appraise different aspects including technological advances, identify gaps, propose several studies improve globally, view identifying moderate-to-severe NPDR who would benefit if convenient treatment option delay progression STDR became available.

Language: Английский

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Chromatic Pupillometry Findings in Alzheimer’s Disease

Frontiers in Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: Aug. 11, 2020

Intrinsically photosensitive melanopsin retinal ganglion cells (mRGCs) are crucial for non-image forming functions of the eye including photoentrainment circadian rhythms and regulation pupillary light reflex (PLR). Chromatic pupillometry can be used to asses mRGCs contribution PLR by using stimuli at different wavelengths. We previously demonstrated in post-mortem AD retinas presence mRGC loss dendritic pathology. In this study, chromatic pupillometry, we a cohort mild-moderate patients transient amplitude abnormalities that may reflect pathology affecting dendrites before involving cell body. This study highlights potentiality as potential biomarker AD. Further studies more severe with longer disease duration cases needed further understand

Language: Английский

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Melanopsin Vision

Published: Dec. 15, 2022

Intrinsically photosensitive retinal ganglion cells (ipRGCs) are the most recently discovered photoreceptor class in human retina. This Element integrates new knowledge and perspectives from visual neuroscience, psychology, sleep science architecture to discuss how melanopsin-mediated ipRGC functions can be measured their circuits manipulated. It reveals contemporary emerging lighting technologies as powerful tools set mind, brain behaviour.

Language: Английский

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Alterations of color vision and pupillary light responses in age-related macular degeneration

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 5, 2023

Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in developed countries and one causes blindness. In this work, we evaluated color pupil light reflex (PLR) to assess visual function patients with early neovascular AMD (NVAMD) compared control group.We recruited 34 dry classified them into two groups following AREDS: 13 NVAMD 24 healthy controls. Controls had acuity (VA) best or equal 20/25 (0.098 logMAR). Color was assessed controls using Cambridge Test (CCT) 2.0 through Trivector protocol. The PLR a Ganzfeld, controlled by RETI-port system. stimuli consisted 1s blue (470 nm) red (631 flashes presented alternately at 2-min intervals. To cone contribution, used flash 2.4 log cd.m-2, background 0.78 cd.m-2. For rods, 470-nm -3 for melanopsin ipRGCs, 470 nm cd.m-2.Patients reduced discrimination all three axes: protan (p = 0.0087), deutan 0.0180), tritan 0.0095) when group. has also been affected NVAMD. amplitude melanopsin-driven response smaller 0.0485) 0.0035) than lower 0.0290) rod-driven response, latency group 0.0041) No changes were found cone-driven responses between groups.Patients present diffusely acquired alteration detected CCT. Rods contributions are CCT may be considered sensitive tests evaluate monitor functional AMD.

Language: Английский

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Early diabetic eye damage: Comparing detection methods using diagnostic power

Survey of Ophthalmology, Journal Year: 2023, Volume and Issue: 69(1), P. 24 - 33

Published: Oct. 4, 2023

It is now clear that retinal neuropathy precedes classical microvascular retinopathy in diabetes. Therefore, tests underpin useful new endpoints must provide high diagnostic power well before the onset of moderate diabetic retinopathy. Hence, we compare detection methods early eye damage. We reviewed data from a range functional and structural studies disease computed standardized effect size as measure power, allowing to be compared quantitatively. then derived minimum performance criteria for clinical endpoints. This included should rapid easy so children with type 1 diabetes can followed into adulthood same tests. also defined attributes lend test further improve using Machine/Deep Learning. Data form objective perimetry suggested are achievable.

Language: Английский

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Multidimensional sleep health and diabetic retinopathy: Systematic review and meta-analysis

Sleep Medicine Reviews, Journal Year: 2023, Volume and Issue: 74, P. 101891 - 101891

Published: Dec. 12, 2023

Language: Английский

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