Published: Jan. 1, 2023
My gratitude also goes to
Language: Английский
Interface Focus, Journal Year: 2020, Volume and Issue: 10(3), P. 20190098 - 20190098
Published: April 17, 2020
At the core of human thought, for majority individuals in developed nations at least, there is tacit assumption that as a species we are unfettered by demands imposed our biology and can do what want, whatever time choose, whereas reality every aspect physiology behaviour constrained 24 h beat arising from deep within evolution. Our daily circadian rhythms sleep/wake cycle allow us to function optimally dynamic world, adjusting day/night cycle. The themes this review focus upon growing realization ignore sleep systems peril, paper considers mechanisms generate regulate systems; happens mechanistically when these collapse result societal pressures disease; how disruption stress linked; why mental illness invariably occur together; employers attempt mitigate some problems associated with working against internal temporal biology. While health costs be reduced, short-term will always significant negative consequences shift work loss. With mind, society needs address issue decide justified workplace.
Language: Английский
Citations
176
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: March 21, 2024
Diabetic retinopathy, nephropathy, and neuropathy are significant microvascular complications of diabetes mellitus, contributing to substantial morbidity mortality worldwide. This comprehensive review examines the clinical relationship between these complications, focusing on shared pathophysiological mechanisms, bidirectional relationships, implications for patient management. The highlights importance understanding interconnected nature diabetic adopting a holistic approach care. Insights gleaned from this underscore necessity early detection, timely intervention, integrated care models involving collaboration among healthcare professionals. Furthermore, emphasizes need continued research elucidate underlying identify novel therapeutic targets, assess efficacy strategies in improving outcomes. By fostering interdisciplinary knowledge exchange, future endeavors hold potential advance our management ultimately enhancing quality life.
Language: Английский
Citations
11
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 17, 2025
It has been reported that hemoglobin (Hb) levels are negatively associated with the prevalence of diabetic retinopathy (DR). This study aims to investigate relationship between Hb and DR among highlanders, who exhibit elevated as an adaptive response hypoxia. cross-sectional, hospital-based utilized data from 645 Tibetan male patients type 2 diabetes (T2D) 2018 2020. Patients were divided into two groups based on level (group 1: 12.0 ≤ < 16.0 g/dL; group 2: ≥ g/dL). was diagnosed fundus photographs fluorescein angiography. Among participants, 140 DR. An inverse observed Each 1.0-g/dL increase in concentration 18% reduction (95% confidence interval [CI]: 0.71-0.95). Multiple logistic regression analysis confirmed higher had adds ratio 0.48 CI, 0.29-0.79) for after adjusting confounders, compared those lower levels. Our findings indicate lowland populations is also applicable high-altitude individuals.
Language: Английский
Citations
0
World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(5)
Published: April 30, 2025
The recently published article by Gao et al identifies risk factors for anxiety and depression in patients with diabetic retinopathy. We supplement that there is pathophysiological evidence to show a complex possibly bidirectional relation between diabetes, retinopathy, mood disorders, especially depression. Longitudinal studies may strengthen proof of causal relationship these diseases. A better understanding can help the holistic management patients.
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2022, Volume and Issue: 17(4), P. e0267848 - e0267848
Published: April 28, 2022
The purposes of this study were to evaluate the mental health among patients with diabetic retinopathy (DR) and explore its' influencing factors. A cross-sectional survey was conducted in Liaoning Province, China. total 200 volunteered participate survey. Psycho-social variables included stress, self-efficacy, resilience, social support. logistic regression analysis used effect psycho-social factors on depression anxiety DR patients. prevalence 25% 13.5% Regression showed that support had a significant protective (95%CI 0.931-0.997) 0.900-0.995). Stress acceleration 1.055-1.253) 1.120-1.457). Family history diabetes 1.856-18.057) other chronic diseases 1.485-12.508) risk for anxiety. high (25.0%) (13.5%) should receive more attention Chinese medical settings. Stress, support, family seemed be crucial relation depressive symptoms. Efficient interventions such as improving decreasing stress considered by administrators aiming at alleviating
Language: Английский
Citations
14
Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 47(3), P. 585 - 592
Published: Aug. 20, 2023
Language: Английский
Citations
8
Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9
Published: April 11, 2022
Objective To evaluate the sensitivity and specificity of a Comprehensive Artificial Intelligence Retinal Expert (CARE) system for detecting diabetic retinopathy (DR) in Chinese community population. Methods This was cross-sectional, diagnostic study. Participants with previous diagnosis diabetes from three healthcare centers were enrolled Single-field color fundus photography obtained analyzed by AI two ophthalmologists. Primary outcome measures included sensitivity, specificity, positive predictive value, negative value their 95% confidence intervals (CIs) DR macular edema (DME). Results In this study, 443 subjects (848 eyes) enrolled, 283 (63.88%) men. The mean age 52.09 (11.51) years (range 18–82 years); 266 eyes diagnosed any DR, 233 more-than-mild (mtmDR), 112 vision-threatening (vtDR), 57 DME. image ability as high 99.06%, whereas its varied significantly different severities. sensitivity/specificity to detect 75.19% (95%CI 69.47–80.17)/93.99% 91.65–95.71), mtmDR 78.97% 73.06–83.90)/92.52% 90.07–94.41), vtDR 33.93% 25.41–43.56)/97.69% 96.25–98.61), DME 47.37% 34.18–60.91)/93.99% 91.65–95.71). Conclusions multicenter cross-sectional study noted safety reliability CARE (especially mtmDR) detection centers. may effectively solve dilemma faced centers: due lack ophthalmic expertise primary physicians, referral are not timely.
Language: Английский
Citations
12
BMJ Open, Journal Year: 2024, Volume and Issue: 14(2), P. e078146 - e078146
Published: Feb. 1, 2024
Objectives Type 2 diabetes mellitus (T2DM) is a serious public health issue. Compared with the general population, patients T2DM have higher risk of poor sleep quality, which could ultimately result in prognosis. Therefore, this study aimed to evaluate quality and its associated factors among Hunan, China. Design This was cross-sectional study. Setting A tertiary hospital Participants Patients hospitalised at Endocrinology Department were consecutively enrolled between March 2021 December 2022. Sociodemographic characteristics, lifestyle T2DM-related information collected retrospectively. Primary secondary outcome measures Sleep evaluated using Pittsburgh Quality Index, cut-off value >7 suggesting quality. Multivariate logistic regression analysis used determine Results Of 1039 participants included, 1001 provided complete data. The mean age sample 60.24±10.09 years, 40.5% (95% CI 37.5% 43.5%) had showed that female sex (adjusted OR (aOR) 1.70, 95% 1.25 2.29), unmarried status (aOR 1.72, 1.05 2.83), diabetic retinopathy 1.38, 1.04 1.83), foot 1.80, 1.11 2.93) per capita monthly household income >5000 RMB 0.66, 0.47 0.93) Conclusions Nearly two-fifths reported Sex, marital status, retinopathy, independently
Language: Английский
Citations
2
Ophthalmology and Therapy, Journal Year: 2023, Volume and Issue: 12(2), P. 1141 - 1153
Published: Feb. 6, 2023
Vision-threatening diabetic retinopathy, a long-term microvascular complication of diabetes in the eye, is major cause blindness worldwide. Sleep regulated by special area brain, and poor quality sleep has been implicated complications, including retinopathy. The study was aimed at exploring whether associated with likelihood developing vision-threatening retinopathy.A matched case-control conducted from 6 May 2022 to September 2022. based on patients (both type 1 2), attending retina clinic referral center. Patients confirmed retinopathy were defined as cases control subjects. Rating done Pittsburgh Quality Index assessment tool. Conditional logistic regression model applied assess effect overall retinopathy.The recruited total 126 (63 duration-matched pairs) diabetes. among 71.90% case groups, significantly higher compared those groups (28.10%) (p < 0.00). mean for [mean (M) = 7.10, standard deviation (SD) 4.30] than group (M 3.60, SD 2.70). magnitude difference [M 3.50, 95% confidence interval (CI): 2.25-4.75] significant. Poor predicted chance cohort.This revealed significant association between Co-management disruption better advisory are warranted.
Language: Английский
Citations
5
Bioengineered, Journal Year: 2021, Volume and Issue: 12(1), P. 3947 - 3956
Published: Jan. 1, 2021
Diabetic retinopathy (DR) represents the most typical complication of type 2 diabetes mellitus and one primary oculopathy causing blindness. However, mechanism DR remains unknown. RIPK1/RIPK3, as homologous serine/threonine kinases, are key elements in mediating necroptosis may have functions development. To clarify relationship between this study established a model apoptosis using high-glucose induced RGCs, which were treated with 7.5, 19.5, 35 mM D-glucose for 12, 24, 48 h, respectively. Subsequently, expression RIPK1/RIPK3 was determined protective effect necrostatin-1 on RGCs injury by high glucose explored. The results demonstrated that RIPK1 RIPK3 cells increased markedly following 12 h treatment 19.5 D-glucose. Additionally, an addition 100 μM medium protein decreased markedly, number Nissl bodies substantially. findings present indicated could induce effectively protect from D-glucose-induced cell necrosis.
Language: Английский
Citations
12