Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

International Journal of Molecular Sciences, Journal Year: 2016, Volume and Issue: 17(9), P. 1534 - 1534

Published: Sept. 13, 2016

Recent advances in nanoscience and nanotechnology radically changed the way we diagnose, treat, prevent various diseases all aspects of human life. Silver nanoparticles (AgNPs) are one most vital fascinating nanomaterials among several metallic that involved biomedical applications. AgNPs play an important role nanotechnology, particularly nanomedicine. Although noble metals have been used for purposes, focused on potential applications cancer diagnosis therapy. In this review, discuss synthesis using physical, chemical, biological methods. We also properties methods their characterization. More importantly, extensively multifunctional bio-applications AgNPs; example, as antibacterial, antifungal, antiviral, anti-inflammatory, anti-angiogenic, anti-cancer agents, mechanism activity AgNPs. addition, therapeutic approaches challenges therapy Finally, conclude by discussing future perspective

Language: Английский

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Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

Advanced Drug Delivery Reviews, Journal Year: 2013, Volume and Issue: 66, P. 2 - 25

Published: Nov. 22, 2013

Language: Английский

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Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

Chemical Reviews, Journal Year: 2016, Volume and Issue: 116(4), P. 2602 - 2663

Published: Feb. 8, 2016

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTDegradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug ReleaseNazila Kamaly§, Basit Yameen§, Jun Wu§, Omid C. Farokhzad*§‡View Author Information§ Laboratory Nanomedicine Biomaterials, Department Anesthesiology, Brigham Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States‡ King Abdulaziz University, Jeddah 21589, Saudi Arabia*E-mail: [email protected]Cite this: Chem. Rev. 2016, 116, 4, 2602–2663Publication Date (Web):February 8, 2016Publication History Received8 June 2015Published online8 February 2016Published inissue 24 2016https://pubs.acs.org/doi/10.1021/acs.chemrev.5b00346https://doi.org/10.1021/acs.chemrev.5b00346review-articleACS PublicationsCopyright © 2016 American Chemical SocietyRequest reuse permissionsArticle Views40762Altmetric-Citations1996LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymers,Drug delivery,Drug release,Pharmaceuticals,Polymers Get e-Alerts

Language: Английский

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Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

Pharmaceutical Research, Journal Year: 2016, Volume and Issue: 33(10), P. 2373 - 2387

Published: June 14, 2016

Language: Английский

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Engineered Nanoparticles for Drug Delivery in Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2014, Volume and Issue: 53(46), P. 12320 - 12364

Published: Oct. 7, 2014

In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve number of issues associated with conventional therapeutic agents, including their poor water solubility (at least, for most anticancer drugs), lack targeting capability, nonspecific distribution, systemic toxicity, and low index. Over the past several decades, remarkable progress been made in development application engineered nanoparticles treat cancer more effectively. For example, agents have integrated optimal sizes, shapes, surface properties increase solubility, prolong circulation half-life, improve biodistribution, reduce immunogenicity. Nanoparticles payloads also favorably delivered into tumors by taking advantage pathophysiological conditions, such enhanced permeability retention effect, spatial variations pH value. Additionally, ligands (e.g., small organic molecules, peptides, antibodies, nucleic acids) added specifically target cancerous cells through selective binding receptors overexpressed on surface. Furthermore, demonstrated that multiple types drugs and/or diagnostic contrast agents) could be same carrier enable combination therapy potential overcome multidrug resistance, real-time readout treatment efficacy. It is anticipated precisely will emerge next-generation platform many other biomedical applications.

Language: Английский

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Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

Journal of Controlled Release, Journal Year: 2014, Volume and Issue: 200, P. 138 - 157

Published: Dec. 26, 2014

Language: Английский

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Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Cancer Research, Journal Year: 2013, Volume and Issue: 73(8), P. 2412 - 2417

Published: Feb. 20, 2013

Enhanced permeability of the tumor vasculature allows macromolecules to enter interstitial space, whereas suppressed lymphatic filtration them stay there. This phenomenon, enhanced and retention (EPR), has been basis nanotechnology platforms deliver drugs tumors. However, progress in developing effective using this approach hampered by heterogeneity EPR effect different tumors limited experimental data from patients on effectiveness mechanism as related drug accumulation. report summarizes workshop discussions key issues major gaps that need be addressed effectively advance nanoparticle-based delivery.

Language: Английский

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Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy

Chemical Reviews, Journal Year: 2016, Volume and Issue: 116(5), P. 2826 - 2885

Published: Jan. 22, 2016

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTNanochemistry and Nanomedicine for Nanoparticle-based Diagnostics TherapyGuanying Chen‡†, Indrajit Roy†§, Chunhui Yang*‡, Paras N. Prasad*†View Author Information† Institute Lasers, Photonics, Biophotonics Department of Chemistry, University at Buffalo, State New York, York 14260, United States‡ School Chemical Engineering Technology, Harbin Harbin, Heilongjiang 150001, China§ Delhi, Delhi 110007, India*E-mail: [email protected]*E-mail: protected]Cite this: Chem. Rev. 2016, 116, 5, 2826–2885Publication Date (Web):January 22, 2016Publication History Received12 March 2015Published online22 January 2016Published inissue 9 2016https://pubs.acs.org/doi/10.1021/acs.chemrev.5b00148https://doi.org/10.1021/acs.chemrev.5b00148review-articleACS PublicationsCopyright © 2016 American SocietyRequest reuse permissionsArticle Views28825Altmetric-Citations1183LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biological imaging,Fluorescence,Metal oxide nanoparticles,Nanoparticles,Quantum dots Get e-Alerts

Language: Английский

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Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery

Chemical Society Reviews, Journal Year: 2012, Volume and Issue: 42(3), P. 1147 - 1235

Published: Dec. 14, 2012

Design and functionalization strategies for multifunctional nanocarriers (e.g., nanoparticles, micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be employed active targeting drug delivery are reviewed. This review will focus the nature of involved in preparation targeted nanocarriers, synthesis methods achieve desired macromolecular architecture, selected coupling strategy, choice homing molecules (vitamins, hormones, peptides, proteins, etc.), as well various display them at surface nanocarriers. The resulting morphologies main colloidal features given an overview biological activities, with a special vivo achievements.

Language: Английский

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Nanoparticles in the clinic

Bioengineering & Translational Medicine, Journal Year: 2016, Volume and Issue: 1(1), P. 10 - 29

Published: March 1, 2016

Nanoparticle/microparticle-based drug delivery systems for systemic (i.e., intravenous) applications have significant advantages over their nonformulated and free counterparts. For example, nanoparticle are capable of delivering therapeutics treating areas the body that other cannot reach. As such, imaging one most investigated in preclinical clinical settings. Here, we will highlight diversity types, key these counterparts, discuss overall potential influencing care. In particular, focus on current trials formulations yet to be clinically approved. Additional emphasis approved systems, both currently indications use active trials. Finally, many often overlooked biological, technological, study design challenges impact success systems.

Language: Английский

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