Gold nanoparticles for cancer radiotherapy: a review DOI Creative Commons

Kaspar Haume,

Soraia Rosa,

Sophie Grellet

et al.

Cancer Nanotechnology, Journal Year: 2016, Volume and Issue: 7(1)

Published: Nov. 3, 2016

Radiotherapy is currently used in around 50% of cancer treatments and relies on the deposition energy directly into tumour tissue. Although it generally effective, some deposited can adversely affect healthy tissue outside volume, especially case photon radiation (gamma X-rays). Improved radiotherapy outcomes be achieved by employing ion beams due to characteristic curve which culminates a localised, high dose (in form Bragg peak). In addition radiotherapy, novel sensitisers, such as nanoparticles, have shown locally increase damaging effect both radiation, when are applied area. Amongst available nanoparticle systems, gold nanoparticles become particularly popular several advantages: biocompatibility, well-established methods for synthesis wide range sizes, possibility coating their surface with large number different molecules provide partial control of, example, charge or interaction serum proteins. This gives full options design parameter combinations, optimal choice not always clear, partially lack understanding many processes that take place upon irradiation complicated systems. this review, we summarise mechanisms action therapy photons ions presence absence well influence core parameters radiosensitisation capabilities.

Language: Английский

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors DOI Creative Commons
Fakhar ud Din, Waqar Aman, Izhar Ullah

et al.

International Journal of Nanomedicine, Journal Year: 2017, Volume and Issue: Volume 12, P. 7291 - 7309

Published: Oct. 1, 2017

Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release damaging normal cells. improve bioavailability therapeutic efficiency of drugs, while providing preferential accumulation at target site. A number nanocarriers developed; however, only a few them are clinically approved drugs intended actions targeted sites. The present review is divided into three main parts: first part presents introduction relevance in anticancer second encompasses targeting mechanisms surface functionalization on third covers description selected tumors, breast, lungs, colorectal pancreatic applications relative these This increases understanding tumor treatment promising use nanotechnology.

Language: Английский

Citations

1273
Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination DOI
Yi-Nan Zhang, Wilson Poon,

Anthony J. Tavares

et al.

Journal of Controlled Release, Journal Year: 2016, Volume and Issue: 240, P. 332 - 348

Published: Jan. 14, 2016

Language: Английский

Citations

1090
Gold Nanomaterials at Work in Biomedicine DOI
Xuan Yang, Miaoxin Yang, Bo Pang

et al.

Chemical Reviews, Journal Year: 2015, Volume and Issue: 115(19), P. 10410 - 10488

Published: Aug. 21, 2015

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTGold Nanomaterials at Work in BiomedicineXuan Yang†, Miaoxin Yang‡, Bo Pang†, Madeline Vara‡, and Younan Xia*†‡§View Author Information† The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute Technology Emory University, Atlanta, 30332, United States‡ § ‡School Chemistry Biochemistry §School Chemical Biomolecular Technology, States*E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 19, 10410–10488Publication Date (Web):August 21, 2015Publication History Received31 March 2015Published online21 August inissue 14 October 2015https://pubs.acs.org/doi/10.1021/acs.chemrev.5b00193https://doi.org/10.1021/acs.chemrev.5b00193review-articleACS PublicationsCopyright © 2015 American SocietyRequest reuse permissionsArticle Views28302Altmetric-Citations964LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Gold,Metal clusters,Metal nanoparticles,Nanoparticles,Nanostructures Get e-Alerts

Language: Английский

Citations

1066
Challenges and strategies in anti-cancer nanomedicine development: An industry perspective DOI Creative Commons

Jennifer I. Hare,

Twan Lammers, Marianne Ashford

et al.

Advanced Drug Delivery Reviews, Journal Year: 2016, Volume and Issue: 108, P. 25 - 38

Published: May 1, 2016

Successfully translating anti-cancer nanomedicines from pre-clinical proof of concept to demonstration therapeutic value in the clinic is challenging. Having made significant advances with drug delivery technologies, we must learn other areas oncology development, where patient stratification and target-driven design have improved outcomes. We should evolve our nanomedicine development strategies build disease into line sight outset. The success small molecule targeted therapies has been significantly by employing a specific decision-making framework, such as AstraZeneca's 5R principle: right target/efficacy, tissue/exposure, safety, patient, commercial potential. With appropriate investment collaboration generate platform evidence supporting end clinical application, similar framework can be established for enhancing translation performance. Building informative data packages answer these questions requires following: (I) an understanding heterogeneity cancers biological factors influencing behaviour tumours; (II) transition formulation-driven research disease-driven development; (III) implementation more relevant animal models testing protocols; (IV) pre-selection patients most likely respond therapies. These challenges overcome improve (the cost-effectiveness of) translation, they are key establishing superior patients.

Language: Английский

Citations

1015
Cancer nanomedicine: a review of recent success in drug delivery DOI Creative Commons
Stephanie Tran,

Peter-Joseph DeGiovanni,

Brandon Piel

et al.

Clinical and Translational Medicine, Journal Year: 2017, Volume and Issue: 6(1)

Published: Dec. 1, 2017

Cancer continues to be one of the most difficult global healthcare problems. Although there is a large library drugs that can used in cancer treatment, problem selectively killing all cells while reducing collateral toxicity healthy cells. There are several biological barriers effective drug delivery such as renal, hepatic, or immune clearance. Nanoparticles loaded with designed overcome these improve efficacy morbidity. Nanomedicine has ushered new era for by improving therapeutic indices active pharmaceutical ingredients engineered within nanoparticles. First generation nanomedicines have received widespread clinical approval over past two decades, from Doxil® (liposomal doxorubicin) 1995 Onivyde® irinotecan) 2015. This review highlights cancer, emphasizing need nanoparticles outcomes. A summary different applications presented. The summarizes recent successes nanomedicine clinic. trials Onivyde leading its 2015 Food and Drug Adminstration highlighted case study success against cancer. Next better targeted specifically destroy cancerous tissue, but face obstacles their development, including identification appropriate biomarkers target, scale-up synthesis, reproducible characterization. These hurdles through multidisciplinary collaborations across academia, industry, regulatory agencies order achieve goal eradicating discusses current use clinically approved nanomedicines, investigation trials, challenges may hinder development treatment.

Language: Английский

Citations

845
Metal–Organic Frameworks for Biomedical Applications DOI
Jie Yang, Ying‐Wei Yang

Small, Journal Year: 2020, Volume and Issue: 16(10)

Published: Feb. 6, 2020

Metal-organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes functional organic ligands through bonds, have attracted extensive research interest during the past decades. Due to unique features diverse compositions, facile synthesis, easy surface functionalization, high areas, adjustable porosity, tunable biocompatibility, MOFs been widely used in hydrogen/methane storage, catalysis, biological imaging sensing, drug delivery, desalination, gas separation, magnetic electronic devices, nonlinear optics, water vapor capture, etc. Notably, with rapid development synthetic methods functionalization strategies, smart MOF-based nanocomposites advanced bio-related properties designed fabricated meet growing demands MOF materials for biomedical applications. This work outlines synthesis recent advances fields, including cargo (drugs, nucleic acids, proteins, dyes) delivery cancer therapy, bioimaging, antimicrobial, biosensing, biocatalysis. The prospects challenges field also discussed.

Language: Английский

Citations

789
Nanocomposite Hydrogels: 3D Polymer–Nanoparticle Synergies for On-Demand Drug Delivery DOI
Sonia Merino, Cristina Martín, Kostas Kostarelos

et al.

ACS Nano, Journal Year: 2015, Volume and Issue: 9(5), P. 4686 - 4697

Published: May 4, 2015

Considerable progress in the synthesis and technology of hydrogels makes these materials attractive structures for designing controlled-release drug delivery systems. In particular, this review highlights latest advances nanocomposite as vehicles. The inclusion/incorporation nanoparticles three-dimensional polymeric is an innovative means obtaining multicomponent systems with diverse functionality within a hybrid hydrogel network. Nanoparticle-hydrogel combinations add synergistic benefits to new 3D structures. Nanogels carriers cancer therapy injectable gels improved self-healing properties have also been described

Language: Английский

Citations

736
Innovative approaches for cancer treatment: current perspectives and new challenges DOI Creative Commons
Carlotta Pucci, Chiara Martinelli, Gianni Ciofani

et al.

ecancermedicalscience, Journal Year: 2019, Volume and Issue: 13

Published: Sept. 10, 2019

Every year, cancer is responsible for millions of deaths worldwide and, even though much progress has been achieved in medicine, there are still many issues that must be addressed order to improve therapy. For this reason, oncological research putting a lot effort towards finding new and efficient therapies which can alleviate critical side effects caused by conventional treatments. Different technologies currently under evaluation clinical trials or have already introduced into practice. While nanomedicine contributing the development biocompatible materials both diagnostic therapeutic purposes, bioengineering extracellular vesicles cells derived from patients allowed designing ad hoc systems univocal targeting strategies. In review, we will provide an in-depth analysis most innovative advances basic applied research.

Language: Английский

Citations

690
Liposomes: structure, composition, types, and clinical applications DOI Creative Commons
Hamdi Nsairat, Dima Khater, Usamah Sayed

et al.

Heliyon, Journal Year: 2022, Volume and Issue: 8(5), P. e09394 - e09394

Published: May 1, 2022

Liposomes are now considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, low immunogenicity. also proved enhance drug solubility controlled distribution, as well capacity surface modifications targeted, prolonged, sustained release. Based on composition, liposomes can be have evolved from conventional, long-circulating, immune-liposomes stimuli-responsive actively targeted liposomes. Many liposomal-based delivery systems currently clinically approved treat several diseases, such cancer, fungal viral infections; more reached advanced phases in clinical trials. This review describes structure, preparation methods, applications.

Language: Английский

Citations

689
Supramolecular chemotherapy based on host–guest molecular recognition: a novel strategy in the battle against cancer with a bright future DOI
Jiong Zhou, Guocan Yu, Feihe Huang

et al.

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 46(22), P. 7021 - 7053

Published: Jan. 1, 2017

Chemotherapy is currently one of the most effective ways to treat cancer. However, traditional chemotherapy faces several obstacles clinical trials, such as poor solubility/stability, non-targeting capability and uncontrollable release drugs, greatly limiting their anticancer efficacy causing severe side effects towards normal tissues. Supramolecular integrating non-covalent interactions a highly promising candidate in this regard can be appropriately used for targeted drug delivery. By taking advantage supramolecular chemistry, some limitations impeding applications solved effectively. Therefore, we present here review summarizing progress cancer treatment based on host-guest recognition provide guidance design new targeting combining diagnostic therapeutic functions. Based large number state-of-the-art studies, our will advance basis promote translational applications.

Language: Английский

Citations

616