Chemical Society Reviews,
Journal Year:
2017,
Volume and Issue:
46(22), P. 7021 - 7053
Published: Jan. 1, 2017
Chemotherapy
is
currently
one
of
the
most
effective
ways
to
treat
cancer.
However,
traditional
chemotherapy
faces
several
obstacles
clinical
trials,
such
as
poor
solubility/stability,
non-targeting
capability
and
uncontrollable
release
drugs,
greatly
limiting
their
anticancer
efficacy
causing
severe
side
effects
towards
normal
tissues.
Supramolecular
integrating
non-covalent
interactions
a
highly
promising
candidate
in
this
regard
can
be
appropriately
used
for
targeted
drug
delivery.
By
taking
advantage
supramolecular
chemistry,
some
limitations
impeding
applications
solved
effectively.
Therefore,
we
present
here
review
summarizing
progress
cancer
treatment
based
on
host-guest
recognition
provide
guidance
design
new
targeting
combining
diagnostic
therapeutic
functions.
Based
large
number
state-of-the-art
studies,
our
will
advance
basis
promote
translational
applications.
Chemical Society Reviews,
Journal Year:
2018,
Volume and Issue:
48(7), P. 2053 - 2108
Published: Sept. 27, 2018
The
nonradiative
conversion
of
light
energy
into
heat
(photothermal
therapy,
PTT)
or
sound
(photoacoustic
imaging,
PAI)
has
been
intensively
investigated
for
the
treatment
and
diagnosis
cancer,
respectively.
By
taking
advantage
nanocarriers,
both
imaging
therapeutic
functions
together
with
enhanced
tumour
accumulation
have
thoroughly
studied
to
improve
pre-clinical
efficiency
PAI
PTT.
In
this
review,
we
first
summarize
development
inorganic
organic
nano
photothermal
transduction
agents
(PTAs)
strategies
improving
PTT
outcomes,
including
applying
appropriate
laser
dosage,
guiding
via
techniques,
developing
PTAs
absorption
in
second
NIR
window,
increasing
(PCE),
also
tumours.
Second,
introduce
advantages
combining
other
therapies
cancer
treatment.
Third,
emerging
applications
cancer-related
research
are
exemplified.
Finally,
perspectives
challenges
combating
especially
regarding
their
clinical
translation,
discussed.
We
believe
that
having
noteworthy
features
would
become
promising
next-generation
non-invasive
theranostic
techniques
our
ability
combat
cancers.
Nature Communications,
Journal Year:
2018,
Volume and Issue:
9(1)
Published: April 11, 2018
Targeted
delivery
approaches
for
cancer
therapeutics
have
shown
a
steep
rise
over
the
past
few
decades.
However,
compared
to
plethora
of
successful
pre-clinical
studies,
only
15
passively
targeted
nanocarriers
(NCs)
been
approved
clinical
use
and
none
actively
NCs
advanced
trials.
Herein,
we
review
principles
behind
determine
potential
reasons
their
limited
translation
success.
We
propose
criteria
considerations
that
must
be
taken
into
account
development
novel
NCs.
also
highlight
possible
directions
tumor
targeting
strategies.
Chemical Reviews,
Journal Year:
2017,
Volume and Issue:
117(22), P. 13566 - 13638
Published: Oct. 19, 2017
The
complexity,
diversity,
and
heterogeneity
of
tumors
seriously
undermine
the
therapeutic
potential
treatment.
Therefore,
current
trend
in
clinical
research
has
gradually
shifted
from
a
focus
on
monotherapy
to
combination
therapy
for
enhanced
treatment
efficacy.
More
importantly,
cooperative
enhancement
interactions
between
several
types
contribute
naissance
multimodal
synergistic
therapy,
which
results
remarkable
superadditive
(namely
"1
+
1
>
2")
effects,
stronger
than
any
single
or
their
theoretical
combination.
In
this
review,
state-of-the-art
studies
concerning
recent
advances
nanotechnology-mediated
will
be
systematically
discussed,
with
an
emphasis
construction
multifunctional
nanomaterials
realizing
bimodal
trimodal
as
well
intensive
exploration
underlying
mechanisms
explaining
significant
improvements
outcome.
Furthermore,
featured
applications
overcoming
tumor
multidrug
resistance,
hypoxia,
metastasis
also
discussed
detail,
may
provide
new
ways
efficient
regression
even
elimination
drug
resistant,
hypoxic
solid,
distant
metastatic
tumors.
Finally,
some
design
tips
outlook
future
development
provided,
highlighting
key
scientific
issues
technical
challenges
requiring
remediation
accelerate
translation.
