Cellular uptake of nanoparticles: journey inside the cell

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 46(14), P. 4218 - 4244

Published: Jan. 1, 2017

Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at cellular subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell-cell communication, structure a manner dictated largely by phenomena nano-bio interface. Recent advances chemical synthesis have yielded new nanoscale precisely defined biochemical features, emerging analytical techniques shed light on nuanced context-dependent within cells. In this review, we provide an objective comprehensive account of our current understanding uptake NPs underlying parameters controlling nano-cellular interactions, along available to follow track processes.

Language: Английский

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Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

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Nanotechnology for Multimodal Synergistic Cancer Therapy

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(22), P. 13566 - 13638

Published: Oct. 19, 2017

The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic potential treatment. Therefore, current trend in clinical research has gradually shifted from a focus on monotherapy to combination therapy for enhanced treatment efficacy. More importantly, cooperative enhancement interactions between several types contribute naissance multimodal synergistic therapy, which results remarkable superadditive (namely "1 + 1 > 2") effects, stronger than any single or their theoretical combination. In this review, state-of-the-art studies concerning recent advances nanotechnology-mediated will be systematically discussed, with an emphasis construction multifunctional nanomaterials realizing bimodal trimodal as well intensive exploration underlying mechanisms explaining significant improvements outcome. Furthermore, featured applications overcoming tumor multidrug resistance, hypoxia, metastasis also discussed detail, may provide new ways efficient regression even elimination drug resistant, hypoxic solid, distant metastatic tumors. Finally, some design tips outlook future development provided, highlighting key scientific issues technical challenges requiring remediation accelerate translation.

Language: Английский

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Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(21), P. 13454 - 13619

Published: Sept. 28, 2021

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.

Language: Английский

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pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

Polymers, Journal Year: 2017, Volume and Issue: 9(4), P. 137 - 137

Published: April 12, 2017

Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than development novel which involve much expense and time. The affected by number factors such as their low aqueous solubility, unequal absorption along gastrointestinal (GI) tract, risk degradation in acidic milieu stomach, permeation upper GI systematic side effects, etc. This review aims enlighten readers on role pH sensitive hydrogels drug delivery, mechanism action, swelling, release function change tract. basis for selection materials, structural features, physical chemical properties, presence ionic pendant groups, influence pKa pKb values ionization, consequent targeted are also highlighted.

Language: Английский

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Advances in Magnetic Nanoparticles for Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2017, Volume and Issue: 7(5)

Published: Dec. 27, 2017

Abstract Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such hyperthermia, drug release, tissue engineering, theranostic, and lab‐on‐a‐chip, due to their exclusive chemical physical properties. Although some works can be found reviewing the main application magnetic NPs area recent intense progress on nanoparticle research, from synthesis surface functionalization strategies, demands for a work that includes, summarizes, debates current directions ongoing advancements this research field. Thus, present addresses structure, synthesis, properties, incorporation nanocomposites, highlighting most relevant effects structural properties how these limit utilization area. Furthermore, review next focuses Finally, discussion challenges outlook future developments use advanced applications critically provided.

Language: Английский

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Stimuli-Responsive Therapeutic Metallodrugs

Chemical Reviews, Journal Year: 2018, Volume and Issue: 119(2), P. 1138 - 1192

Published: Oct. 9, 2018

The success of platinum-based anticancer agents has motivated the exploration novel metal-based drugs for several decades, whereas problems such as drug-resistance and systemic toxicity hampered their clinical applications efficacy. Stimuli-responsiveness some metal complexes offers a good opportunity designing site-specific prodrugs to maximize therapeutic efficacy minimize side effect metallodrugs. This review presents comprehensive up-to-date overview on stimuli-responsive metallodrugs that have appeared in past two where stimuli redox, pH, enzyme, light, temperature, so forth were involved. compounds are classified into three major categories based nature stimuli, is, endo-stimuli-responsive metallodrugs, exo-stimuli-responsive dual-stimuli-responsive Representative examples each type discussed terms structure, response mechanism, potential medical applications. In end, future opportunities challenges this field tentatively proposed. With diverse being introduced, foci pointed platinum ruthenium complexes.

Language: Английский

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Pharmacokinetic aspects of retinal drug delivery

Progress in Retinal and Eye Research, Journal Year: 2016, Volume and Issue: 57, P. 134 - 185

Published: Dec. 24, 2016

Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect retina and choroid leading impaired vision or blindness. Currently, intravitreal injections are method of choice administer drugs retina, but this approach applicable only selected cases (e.g. anti-VEGF antibodies soluble receptors). There two basic approaches that can be adopted improve retinal drug delivery: prolonged and/or targeted use other routes administration, such as periocular, suprachoroidal, sub-retinal, systemic, topical. Properties administration route, system determine efficacy safety these approaches. Pharmacokinetic pharmacodynamic factors required dosing rates doses needed for action. In addition, tolerability limit materials ocular delivery. This review article provides a critical discussion delivery, particularly from pharmacokinetic point view. does not include extensive technologies, they have already been reviewed several times recently. Instead, we aim provide systematic quantitative view on segment. based literature unpublished data authors' laboratory.

Language: Английский

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Nanopharmaceuticals and Nanomedicines Currently on the Market: Challenges and Opportunities

Nanomedicine, Journal Year: 2018, Volume and Issue: 14(1), P. 93 - 126

Published: Nov. 19, 2018

There has been a revolution in nanotechnology and nanomedicine. Since 1980, there remarkable increase approved nano-based pharmaceutical products. These novel systems can either be therapeutic agents themselves, or else act as vehicles to carry different active into specific parts of the body. Currently marketed nanostructures include nanocrystals, liposomes lipid nanoparticles, PEGylated polymeric nanodrugs, other polymers, protein-based nanoparticles metal-based nanoparticles. A range issues must addressed development these nanostructures. Ethics, market size, possibility failure, costs commercial development, are some topics which on table discussed. After passing all ethical biological assessments, satisfying investors future profitability, only handful nanoformulations, successfully obtained marketing approval. We survey nanomedicines that have received regulatory approval marketed. discuss ethics, costs, possible failure. estimate global nanomedicine size growth. Our goal is summarize nanoformulations market, briefly cover challenges outlook.

Language: Английский

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Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Advanced Drug Delivery Reviews, Journal Year: 2017, Volume and Issue: 123, P. 33 - 64

Published: Aug. 4, 2017

Language: Английский

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