Engineering precision nanoparticles for drug delivery

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 20(2), P. 101 - 124

Published: Dec. 4, 2020

Language: Английский

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Surface-Enhanced Raman Spectroscopy for Bioanalysis: Reliability and Challenges

Chemical Reviews, Journal Year: 2018, Volume and Issue: 118(10), P. 4946 - 4980

Published: April 11, 2018

Surface-enhanced Raman spectroscopy (SERS) inherits the rich chemical fingerprint information on and gains sensitivity by plasmon-enhanced excitation scattering. In particular, most peaks have a narrow width suitable for multiplex analysis, measurements can be conveniently made under ambient aqueous conditions. These merits make SERS very promising technique studying complex biological systems, has attracted increasing interest in biorelated analysis. However, there are still great challenges that need to addressed until it widely accepted communities, answer interesting questions, solve fatal clinical problems. applications bioanalysis involve interactions of plasmonic nanomaterials with systems their environments. The reliability becomes key issue bioanalytical order extract meaningful from data. This review provides comprehensive overview main focus issue. We first introduce mechanism guide design reliable experiments high detection sensitivity. then current understanding interaction mainly living cells, functionalized nanoparticles target detection. further status label-free (direct) labeled (indirect) detections, biomolecules, pathogens, we discuss potential interferences experimental design, measurement conditions, data end, give an outlook SERS, including reproducibility, sensitivity, spatial time resolution.

Language: Английский

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Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

Nanoscale Research Letters, Journal Year: 2018, Volume and Issue: 13(1)

Published: Oct. 25, 2018

Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This perhaps even more evident in field nanomedicine whereby nanoparticles have been used as a tool for treatment diagnosis many diseases. However, despite tremendous benefit conferred, common pitfalls this technology its potential short long-term effects on human body. To understand these issues, studies carried out. review attempts to shed light some outcomes. The topics that were examined include different possible uptake pathways intracellular trafficking routes. Additionally, effect physicochemical properties nanoparticle such size, shape, charge surface chemistry determining mechanism biological function are also addressed.

Language: Английский

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TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

Nature Biomedical Engineering, Journal Year: 2018, Volume and Issue: 2(8), P. 578 - 588

Published: May 18, 2018

Language: Английский

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Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

Advanced Drug Delivery Reviews, Journal Year: 2019, Volume and Issue: 143, P. 68 - 96

Published: March 1, 2019

Language: Английский

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Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(9), P. 5397 - 5434

Published: Jan. 1, 2021

Nanoparticles (NPs) have attracted considerable attention in various fields, such as cosmetics, the food industry, material design, and nanomedicine. In particular, fast-moving field of nanomedicine takes advantage features NPs for detection treatment different types cancer, fibrosis, inflammation, arthritis well neurodegenerative gastrointestinal diseases. To this end, a detailed understanding NP uptake mechanisms by cells intracellular localization is essential safe efficient therapeutic applications. first part review, we describe several endocytic pathways involved internalization discuss impact physicochemical properties on process. addition, potential challenges using inhibitors, markers genetic approaches to study endocytosis are addressed along with principal (semi) quantification methods uptake. The second focuses synthetic bio-inspired substances, which can stimulate or decrease cellular NPs. This approach could be interesting where high accumulation drugs target desirable clearance immune avoided. review contributes an improved reveals used improve delivery.

Language: Английский

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Minimum information reporting in bio–nano experimental literature

Nature Nanotechnology, Journal Year: 2018, Volume and Issue: 13(9), P. 777 - 785

Published: Aug. 30, 2018

Language: Английский

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2D Black Phosphorus–Based Biomedical Applications

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 29(13)

Published: Feb. 4, 2019

Abstract Black phosphorus (BP) has increasingly attracted scientific attention since its first applications in biomedicine due to unique properties and excellent biocompatibility. In particular, layer‐dependent bandgap, moderate carrier mobility, large surface‐area‐to‐volume ratio, biodegradability, intrinsic photoacoustic properties, biocompatibility make it an ideal candidate for use photothermal therapy, photodynamic drug delivery, 3D printing, bioimaging, biosensing, theranostics, which are reviewed here. addition, the article discusses strategies overcome challenges related surface instability chemical degradation, a major obstacle application. This review not only provides comprehensive summary on BP preparation biomedical but also summarizes recent research future possibilities.

Language: Английский

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2D Nanomaterials for Cancer Theranostic Applications

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(13)

Published: July 28, 2019

Abstract 2D nanomaterials with unique nanosheet structures, large surface areas, and extraordinary physicochemical properties have attracted tremendous interest. In the area of nanomedicine, research on graphene its derivatives for diverse biomedical applications began as early 2008. Since then, many other types nanomaterials, including transition metal dichalcogenides, carbides, nitrides carbonitrides, black phosphorus nanosheets, layered double hydroxides, metal–organic framework been explored in nanomedicine over past decade. particular, a makes highly efficient drug delivery nanoplatforms. The optical and/or X‐ray attenuation can be harnessed phototherapy or radiotherapy cancer. Furthermore, by integrating functional nanoparticles utilizing their inherent physical properties, may also engineered nanoprobes multimodal imaging tumors. shown substantial potential cancer theranostics. Herein, latest progress development theranostic is summarized. Current challenges future perspectives applied are discussed.

Language: Английский

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Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 47(10), P. 3574 - 3620

Published: Jan. 1, 2018

Peptide- and protein-nanoparticle conjugates have emerged as powerful tools for biomedical applications, enabling the treatment, diagnosis, prevention of disease. In this review, we focus on key roles played by peptides proteins in improving, controlling, defining performance nanotechnologies. Within framework, provide a comprehensive overview sequences structures utilised to biological physical stability nano-constructs, direct particles their target influence cellular tissue distribution, induce control responses, form polypeptide self-assembled nanoparticles. doing so, highlight great advances made field, well challenges still faced achieving clinical translation peptide- protein-functionalised nano-drug delivery vehicles, imaging species, active therapeutics.

Language: Английский

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