A Magnetofluorescent Carbon Dot Assembly as an Acidic H₂O₂‐Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(13)

Published: Feb. 13, 2018

Abstract Recent studies indicate that carbon dots (CDs) can efficiently generate singlet oxygen ( 1 O 2 ) for photodynamic therapy (PDT) of cancer. However, the hypoxic tumor microenvironment and rapid consumption in PDT process will severely limit therapeutic effects CDs due to oxygen‐dependent PDT. Thus, it is becoming particularly important develop a novel CD as an situ oxygenerator overcoming hypoxia substantially enhancing efficacy. Herein, first time, magnetofluorescent Mn‐CDs are successfully prepared using manganese(II) phthalocyanine precursor. After cooperative self‐assembly with DSPE‐PEG, obtained Mn‐CD assembly be applied smart contrast agent both near‐infrared fluorescence (FL) (maximum peak at 745 nm) T ‐weighted magnetic resonance (MR) (relaxivity value 6.97 mM −1 s imaging. More interestingly, not only effectively produce (quantum yield 0.40) but also highly catalyze H oxygen. These collective properties enable utilized acidic ‐driven increase concentration solid tumors simultaneous bimodal FL/MR imaging enhanced This work explores new biomedical use provides versatile nanomaterial candidate multifunctional nanotheranostic applications.

Language: Английский

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Conquering the Hypoxia Limitation for Photodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due the hypoxic nature characteristic of many solid tumors, PDT is frequently limited therapeutic effect. Moreover, consumption O2 during may further aggravate tumor condition, which promotes proliferation, metastasis, invasion resulting poor prognosis treatment. Therefore, numerous efforts have been made increase content with goal enhancing efficacy. Herein, these strategies developed past decade are comprehensively reviewed alleviate hypoxia, including 1) delivering exogenous directly, 2) generating situ, 3) reducing cellular by inhibiting respiration, 4) regulating TME, (e.g., normalizing vasculature or disrupting extracellular matrix), 5) hypoxia-inducible factor 1 (HIF-1) signaling pathway relieve hypoxia. Additionally, -independent Type-I also discussed as an alternative strategy. By reviewing progress, it hoped that this review will provide innovative perspectives new nanomaterials designed combat hypoxia avoid associated limitation PDT.

Language: Английский

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A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Nov. 22, 2018

Abstract Photodynamic therapy (PDT) is ineffective against deeply seated metastatic tumors due to poor penetration of the excitation light. Herein, we developed a biomimetic nanoreactor (bio-NR) achieve synergistic chemiexcited photodynamic-starvation tumor metastasis. Photosensitizers on hollow mesoporous silica nanoparticles (HMSNs) are excited by chemical energy in situ deep generate singlet oxygen ( 1 O 2 ) for PDT, and glucose oxidase (GOx) catalyzes into hydrogen peroxide (H ). Remarkably, this process not only blocks nutrient supply starvation but also provides H synergistically enhance PDT. Cancer cell membrane coating endows nanoparticle with biological properties homologous adhesion immune escape. Thus, bio-NRs can effectively convert tumors. The excellent therapeutic effects vitro vivo indicate their great potential cancer metastasis therapy.

Language: Английский

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ROS‐Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy

Advanced Materials, Journal Year: 2017, Volume and Issue: 29(33)

Published: July 6, 2017

The application of nanoparticles (NPs) to drug delivery has led the development novel nanotherapeutics for treatment various diseases including cancer. However, clinical use NP-mediated not always translated into improved survival cancer patients, in part due suboptimal properties NP platforms, such as premature leakage during preparation, storage, or blood circulation, lack active targeting tumor tissue and cells, poor penetration. Herein, an innovative reactive oxygen species (ROS)-responsive polyprodrug is reported that can self-assemble stable NPs with high loading. This new platform composed following key components: (i) inner core respond ROS triggered release intact therapeutic molecules, (ii) polyethylene glycol (PEG) outer shell prolong circulation; (iii) surface-encoded internalizing RGD (iRGD) enhance These targeted ROS-responsive show significant inhibition cell growth both vitro vivo.

Language: Английский

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A Highly Efficient and Photostable Photosensitizer with Near‐Infrared Aggregation‐Induced Emission for Image‐Guided Photodynamic Anticancer Therapy

Advanced Materials, Journal Year: 2017, Volume and Issue: 29(33)

Published: July 3, 2017

Photodynamic therapy (PDT), which relies on photosensitizers (PS) and light to generate reactive oxygen species kill cancer cells or bacteria, has attracted much attention in recent years. PSs with both bright emission efficient singlet generation have also been used for image-guided PDT. However, simultaneously achieving effective 1 O2 generation, long wavelength absorption, stable near-infrared (NIR) low dark toxicity a single PS remains challenging. In addition, it is well known that when traditional are made into nanoparticles, they encounter quenched fluorescence reduced production. this contribution, these challenging issues successfully addressed through designing the first photostable photosensitizer aggregation-induced NIR very aggregate state. The yielded nanoparticles show centered at 820 nm, excellent photostability, good biocompatibility, negligible vivo toxicity. Both vitro experiments prove candidates photodynamic anticancer therapy.

Language: Английский

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