Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

ACS Central Science, Journal Year: 2020, Volume and Issue: 6(12), P. 2179 - 2195

Published: Dec. 14, 2020

Carbon dots (CDs), as a new type of carbon-based nanomaterial, have attracted broad research interest for years, because their diverse physicochemical properties and favorable attributes like good biocompatibility, unique optical properties, low cost, ecofriendliness, abundant functional groups (e.g., amino, hydroxyl, carboxyl), high stability, electron mobility. In this Outlook, we comprehensively summarize the classification CDs based on analysis formation mechanism, micro-/nanostructure property features, describe synthetic methods including strong absorption, photoluminescence, phosphorescence. Furthermore, recent significant advances in applications, (sensor, anticounterfeiting), energy (light-emitting diodes, catalysis, photovoltaics, supercapacitors), promising biomedicine, are systematically highlighted. Finally, envisage key issues to be challenged, future directions, perspectives show full picture CDs-based materials.

Language: Английский

---

Evolution and Synthesis of Carbon Dots: From Carbon Dots to Carbonized Polymer Dots

Advanced Science, Journal Year: 2019, Volume and Issue: 6(23)

Published: Sept. 30, 2019

Abstract Despite the various synthesis methods to obtain carbon dots (CDs), bottom‐up are still most widely administrated route afford large‐scale and low‐cost synthesis. However, as CDs developed with increasing reports involved in producing many CDs, structure property features have changed enormously compared first generation of raising classification concerns. To this end, a new named carbonized polymer (CPDs), is summarized according analysis features. Here, CPDs revealed an emerging class distinctive polymer/carbon hybrid structures properties. Furthermore, deep insights into effects on structure/property provided. Herein, also detail, conditions terms properties discussed analyzed comprehensively. Insights formation process nucleation mechanism offered. Finally, perspective future development proposed critical facilitating their potential application fields.

Language: Английский

---

Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2018, Volume and Issue: 57(36), P. 11522 - 11531

Published: May 29, 2018

Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with oxygen-dependent nature, which limits effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this of PDT. These efforts, are summarized in review, produced many innovative methods to avoid the PDT hypoxia.

Language: Английский

---

Photosensitizers for Photodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2019, Volume and Issue: 8(13)

Published: May 8, 2019

Abstract As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in presence (O 2 ). However, further advancements including tumor selectivity and ROS generation efficiency still required. Substantial efforts devoted to design synthesize smart PSs with optimized properties achieving a desirable therapeutic efficacy. This review summarizes recent progress developing intelligent efficient PDT, ranging from single molecules delicate nanomaterials. The strategies improve through optimizing photoinduced electron transfer energy processes highlighted. Moreover, approaches combine PDT other therapeutics (e.g., chemotherapy, photothermal therapy, radiotherapy) targeted delivery cells or tissue introduced. main challenges application also discussed.

Language: Английский

---

A multifunctional chemical toolbox to engineer carbon dots for biomedical and energy applications

Nature Nanotechnology, Journal Year: 2022, Volume and Issue: 17(2), P. 112 - 130

Published: Feb. 1, 2022

Language: Английский

---

The light of carbon dots: From mechanism to applications

Matter, Journal Year: 2022, Volume and Issue: 5(1), P. 110 - 149

Published: Jan. 1, 2022

Language: Английский

---

Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Jan. 17, 2020

Hypoxia of solid tumor compromises the therapeutic outcome photodynamic therapy (PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting ruthenium as active catalytic site anchored in metal-organic framework Mn3[Co(CN)6]2 with encapsulated chlorin e6 (Ce6), which serves catalase-like nanozyme for generation. Coordination-driven self-assembly organic linkers metal ions presence biocompatible polymer generates nanoscale network adaptively encapsulates Ce6. The resulted SAE possesses well-defined morphology, uniform size distribution high loading capacity. When conducting situ generation through reaction between endogenous H2O2 Ru species SAE, hypoxia microenvironment is relieved. Our study demonstrates promising efficient sites cancer treatment.

Language: Английский

---

Conquering the Hypoxia Limitation for Photodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due the hypoxic nature characteristic of many solid tumors, PDT is frequently limited therapeutic effect. Moreover, consumption O2 during may further aggravate tumor condition, which promotes proliferation, metastasis, invasion resulting poor prognosis treatment. Therefore, numerous efforts have been made increase content with goal enhancing efficacy. Herein, these strategies developed past decade are comprehensively reviewed alleviate hypoxia, including 1) delivering exogenous directly, 2) generating situ, 3) reducing cellular by inhibiting respiration, 4) regulating TME, (e.g., normalizing vasculature or disrupting extracellular matrix), 5) hypoxia-inducible factor 1 (HIF-1) signaling pathway relieve hypoxia. Additionally, -independent Type-I also discussed as an alternative strategy. By reviewing progress, it hoped that this review will provide innovative perspectives new nanomaterials designed combat hypoxia avoid associated limitation PDT.

Language: Английский

---

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(10)

Published: Jan. 28, 2020

Abstract Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO 2 , MnO, Mn O 3 4 x ) their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, representative progresses MONs synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, are mainly introduced. First, five kinds primary synthetic methods presented, thermal decomposition method, exfoliation strategy, permanganates reduction adsorption–oxidation hydro/solvothermal. Second, preparations hollow composite materials summarized specially. Then, chemical toxicity discussed. Next, diagnostic imaging sensing outlined. Finally, some rational designs photodynamic therapy, photothermal chemodynamic sonodynamic radiotherapy, magnetic hyperthermia, chemotherapy, gene starvation ferroptosis, immunotherapy, various combination highlighted.

Language: Английский

---

Carbon Dots for In Vivo Bioimaging and Theranostics

Small, Journal Year: 2019, Volume and Issue: 15(32)

Published: Feb. 18, 2019

Carbon dots (CDs), a kind of carbon material discovered accidentally, exhibit unexpected advantages in fluorescence imaging/sensing such as photostability, biocompatibility, and low toxicity. For emerging theranostics, an interdiscipline created by integrating therapy diagnostics, CDs are good candidates when they combined with targeted chemo/gene/photodynamic/photothermal therapeutic moieties. Here, the development nanomedicine is reviewed from their use original imaging agents and/or drug carriers to multifunctional theranostic systems. Finally, challenges prospects next-generation CD-based theranostics for clinical applications also discussed.

Language: Английский

---