International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(18), P. 9861 - 9861
Published: Sept. 13, 2021
Aziridination
reactions
represent
a
powerful
tool
in
aziridine
synthesis.
Significant
progress
has
been
achieved
this
field
the
last
decades,
whereas
highly
functionalized
aziridines
including
3-arylated
aziridine-2-carbonyl
compounds
play
an
important
role
both
medical
and
synthetic
chemistry.
For
reasons
listed,
current
review
we
have
focused
on
ways
to
obtain
recent
advances
(mainly
since
year
2000)
methodology
of
synthesis
these
via
aziridination.
Organic & Biomolecular Chemistry,
Journal Year:
2020,
Volume and Issue:
18(42), P. 8572 - 8596
Published: Jan. 1, 2020
Spiro-epoxy/aziridine
oxindole
frameworks
are
considered
as
an
efficient
structural
toolbox
to
obtain
C3-functionalised
derivatives.
These
3,3'-spiro-cyclic
precursors
highly
susceptible
towards
nucleophiles
owing
their
inherent
ring
strain.
Their
versatile
reactivity
has
opened
many
potential
synthetic
transformations,
allowing
access
bioactive
molecules
well
natural
products.
The
present
review
aims
elaborate
various
enabling
strategies
applied
in
the
successful
synthesis
of
strained
spiro-cyclic
scaffolds.
Furthermore,
nucleophilic
ring-opening/expansion
and
cycloaddition
reactions
spiro-epoxy/aziridine
discussed.
Moreover,
mechanistic
insights
define
regio-
stereo-chemical
outcome
products
have
also
been
highlighted
briefly.
RSC Advances,
Journal Year:
2016,
Volume and Issue:
6(77), P. 73848 - 73852
Published: Jan. 1, 2016
An
oxindole
decorated
4H-chromene
scaffold
has
been
synthesized
in
water
under
catalyst-free
reaction
conditions
at
ambient
temperature
by
integrating
the
guiding
principles
of
Diversity
Oriented
Synthesis
(DOS)
and
green
chemistry.
The Journal of Organic Chemistry,
Journal Year:
2017,
Volume and Issue:
82(22), P. 11903 - 11908
Published: July 27, 2017
An
iodide-mediated
reaction
between
cyclic
iodonium
ylides
of
1,3-dicarbonyls
and
3-alkylidene-2-oxindoles
results
in
3H-spiro[furan-2,3′-indolin]-2′-ones.
The
was
tolerant
to
substitutions
on
both
the
alkylidene
ylide
substrates
provided
access
19
new,
densely
functionalized
polycyclic
spirocycles
typically
high
yield.
Organic Letters,
Journal Year:
2018,
Volume and Issue:
20(11), P. 3156 - 3160
Published: May 16, 2018
A
range
of
novel
(poly)cyclic
alkaloids
incorporating
an
unprecedented
1,5-diazaspiro[2.4]heptane
core
that
carry
a
spiro
NH
aziridine
moiety
and
7-vinyl
group
are
constructed
from
the
thermal
reaction
vinyl
azides
with
tethered
alkenes.
Vinyl
converted
to
2H-azirines
in
situ,
which
serve
as
enophiles
for
intramolecular
imino-ene
reactions
suitable
High
stereoselectivity
specificity
have
been
achieved
this
azirines.
