Background:
Benzo[4,5]imidazo[1,2-a]pyridine
derivatives
were
accessed
through
an
efficient
pseudo
three
component
reaction
between
dialdehydes
such
as
o-phthalaldehyde,
glutaraldehyde,
2,3-thiophenedicarboxaldehyde
and
the
active
methylene
2-(1H-benzo[d]imidazol-2-yl)acetonitrile.The
products
obtained
in
a
one-pot
manner
with
easy
purification
further
characterized
by
NMR,
FT-IR
HRMS
spectral
data
(Figure
1)..
Figure
1
Benzo
[4,5]imidazo[1,2-a]pyridine.
Polymer Chemistry,
Journal Year:
2023,
Volume and Issue:
14(15), P. 1801 - 1808
Published: Jan. 1, 2023
In
this
work,
polypeptide
nanogels
were
prepared
by
an
innovative
strategy
of
ring-opening
polymerization
induced
nano-gelation
using
α-amino-poly(ethylene
oxide)
(mPEG-NH
2
)
as
a
macroinitiator
in
aqueous
solution.
Journal of Medicinal Chemistry,
Journal Year:
2017,
Volume and Issue:
60(14), P. 5955 - 5968
Published: April 5, 2017
With
the
development
of
ever-expanding
synthetic
methodologies,
a
medicinal
chemist's
toolkit
continues
to
swell.
However,
with
finite
time
and
resources
as
well
growing
understanding
our
field's
environment
impact,
it
is
critical
refine
what
can
be
made
should
made.
This
review
seeks
highlight
multiple
cheminformatic
approaches
in
drug
discovery
that
influence
triage
design
execution
impacting
likelihood
rapidly
generating
high-value
molecules
more
sustainable
manner.
strategy
gives
chemists
tools
vast
libraries,
stress
"druglikeness",
identify
SAR
trends.
Project
success,
i.e.,
identification
clinical
candidate,
then
reached
faster
fewer
farther-reaching
ramification
using
less
waste,
thereby
helping
"green"
field.
Current Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
25(7), P. 779 - 818
Published: Jan. 12, 2021
The
role
of
oxindole
derivatives
is
discussed
as
starting
materials
in
diverse
organic
reactions,
including
two
and
more
components,
between
the
years
2014
until
2020.
Oxindoles
are
famous
because
their
biological
properties.
For
instance,
chromanone-fused
polycyclic
pyrrolidinyl-dispirooxindoles,
functionalized
spiro-fused
carbocyclicoxindole,
3,3-disubstituted
oxindoles
have
anti-cancer,
anti-tumor,
anti-microbial
properties,
respectively.
Therefore,
various
methods
for
synthesizing
structures
received
much
attention
chemistry.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(4), P. 2556 - 2570
Published: Jan. 26, 2024
Herein,
we
report
a
highly
efficient
Ag(I)-catalyzed
indolyzation
with
Friedel–Crafts
alkylation
through
cascade
cyclization
strategy
for
accessing
valuable
hybrid
heterocycles
the
first
time.
This
general
consists
of
forming
four
C–C/C–N/C–O
bonds
toward
dual
annulation
reactions
2-alkynylanilines
methyl
benzoate-2-carboxaldehydes
and
aromatic
amines,
as
well
salicylaldehydes
malononitrile.
Variably
substituted
new
indolo-4H-phthalimidines
indolo-4H-chromenes
were
synthesized
excellent
yields
(85–93%)
under
mild
reaction
conditions.
Organic & Biomolecular Chemistry,
Journal Year:
2020,
Volume and Issue:
18(16), P. 3082 - 3092
Published: Jan. 1, 2020
Skeletally
diverse
and
complex
polyheterocyclic
hybrid
scaffolds
have
been
accessed
via
one-pot
three-component
reaction
by
exploiting
the
build/couple/pair
strategy
of
diversity
oriented
synthesis.
