Rare-Earth Doping in Nanostructured Inorganic Materials

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5519 - 5603

Published: Jan. 6, 2022

Impurity doping is a promising method to impart new properties various materials. Due their unique optical, magnetic, and electrical properties, rare-earth ions have been extensively explored as active dopants in inorganic crystal lattices since the 18th century. Rare-earth can alter crystallographic phase, morphology, size, leading tunable optical responses of doped nanomaterials. Moreover, control ultimate electronic catalytic performance nanomaterials scalable manner, enabling significant improvements energy harvesting conversion. A better understanding critical role prerequisite for development an extensive repertoire functional practical applications. In this review, we highlight recent advances associated applications many fields. This review covers key criteria doping, including basic structures, lattice environments, strategies, well fundamental design principles that enhance electrical, catalytic, magnetic material. We also discuss future research directions challenges controlling

Language: Английский

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Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead

Advanced Science, Journal Year: 2018, Volume and Issue: 5(10)

Published: July 19, 2018

Great and interdisciplinary research efforts have been devoted to the biomedical applications of 2D materials because their unique planar structure prominent physiochemical properties. Generally, ceramic-based biomaterials, fabricated by high-temperature solid-phase reactions, are preferred as bone scaffolds in hard tissue engineering controllable biocompatibility satisfactory mechanical property, but potential disease theranostics paid much less attention, mainly due lack related material functionalities for possibly entering circulating within vascular system. The emerging MXenes, a family ultrathin atomic nanosheet derived from MAX phase ceramics, currently booming novel inorganic nanosystems biologic applications. metallic conductivity, hydrophilic nature, other performances make it possible MXenes meet strict requirements biomedicine. This work introduces very recent progress paradigms state-of-the-art applications, focusing on design/synthesis strategies, therapeutic modalities, diagnostic imaging, biosensing, antimicrobial, biosafety issues. It is highly expected that elaborately engineered nanosheets will become one most attractive biocompatible nanoplatforms multiple extensive profit clinical translation nanomedicine.

Language: Английский

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Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(49)

Published: July 29, 2018

Optical imaging has played a pivotal role in biology and medicine, but it faces challenges of relatively low tissue penetration poor signal-to-background ratio due to light scattering autofluorescence. To overcome these issues, second near-infrared fluorescence, self-luminescence, photoacoustic have recently emerged, which utilize an optical region with reduced light-tissue interactions, eliminate real-time excitation, detect acoustic signals negligible attenuation, respectively. Because there are only few endogenous molecules absorbing or emitting above the visible region, development contrast agents is essential for those deep-tissue modalities. Organic semiconducting π-conjugated frameworks can be synthesized meet different requirements their easy chemical modification legible structure-property relation. Herein, applications organic including small-molecule nanoparticle derivatives summarized. In particular, molecular engineering nanoformulation approaches further improve detection sensitivity modalities highlighted. Finally, current potential opportunities this emerging subfield biomedical discussed.

Language: Английский

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Multimodal Biophotonics of Semiconducting Polymer Nanoparticles

Accounts of Chemical Research, Journal Year: 2018, Volume and Issue: 51(8), P. 1840 - 1849

Published: Aug. 3, 2018

ConspectusBiophotonics as an interdisciplinary frontier plays increasingly important role in modern biomedical science. Optical agents are generally involved biophotonics to interpret biomolecular events into readable optical signals for imaging and diagnosis or convert photons other forms of energy (such heat, mechanical force, chemical radicals) therapeutic intervention biological stimulation. Development new including metallic nanoparticles, quantum dots, up-conversion carbon silica nanoparticles has contributed the advancement this field. However, most these have their own merits demerits, making them less effective multimodal biophotonic platforms.In Account, we summarize our recent work on development near-infrared (NIR) semiconducting polymer (SPNs) light converters advanced biophotonics. SPNs composed π-electron delocalized polymers (SPs) often possess advantages good biocompatibility, high photostability, large absorption coefficients. Because photophysical properties mainly determined by molecular structures precursor polymers, engineering allows us fine tune processes obtain different responses, even second NIR window (1000–1700 nm). Meanwhile, facile nanoformulation methods enable alteration outer inner diverse interactions.The unique brought about ultrasensitive deep-tissue imaging. NIR-absorbing with strong charge-transfer backbones can photoenergy acoustic waves, permitting photoacoustic that bypasses issue scattering reaches centimeter tissue penetration depth. Differently, phenylenevinylene-containing store photon via defects emit long-NIR afterglow luminescence a half-life ∼6 min after cessation excitation. Such process avoids autofluorescence, giving rise ultrahigh signal-to-background ratios. So far, SPN-based probes been developed image disease tissues (tumors), biomarkers (biothiols reactive oxygen species), physiological indexes (pH temperature) preclinical animal models.The synthetic flexibility further permits light-modulated interventions. Till now, photothermal conversion efficiencies shaped transducers remotely regulate protein ion channels, enzymatic activity, gene expression. In conjunction desired biodistribution tumor-homing ability, doped coated inorganic amplified self-regulated photodynamic cancer therapy.This Account thus demonstrates serve nanoplatform provide unprecedented opportunities imaging, noninvasive bioactivation, therapy.

Language: Английский

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Trends in Micro‐/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 4, 2020

Abstract Micro‐/nanorobots (m‐bots) have attracted significant interest due to their suitability for applications in biomedical engineering and environmental remediation. Particularly, vivo diagnosis intervention been the focus of extensive research recent years with various clinical imaging techniques being applied localization tracking. The successful integration well‐designed m‐bots surface functionalization, remote actuation systems, becomes crucial step toward applications, especially uses. This review thus addresses four different aspects m‐bots: design/fabrication, actuation, localization. diagnosis, sensing, microsurgery, targeted drug/cell delivery, thrombus ablation, wound healing are reviewed from these viewpoints. developed m‐bot systems comprehensively compared evaluated based on characteristics. current challenges directions future this field summarized.

Language: Английский

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The Future of Nanotechnology in Plant Pathology

Annual Review of Phytopathology, Journal Year: 2018, Volume and Issue: 56(1), P. 111 - 133

Published: Aug. 25, 2018

Engineered nanoparticles are materials between 1 and 100 nm exist as metalloids, metallic oxides, nonmetals, carbon nanomaterials functionalized dendrimers, liposomes, quantum dots. Their small size, large surface area, high reactivity have enabled their use bactericides/ fungicides nanofertilizers. Nanoparticles can be designed biosensors for plant disease diagnostics delivery vehicles genetic material, probes, agrichemicals. In the past decade, reports of nanotechnology in phytopathology grown exponentially. Nanomaterials been integrated into management strategies molecular tools. Most summarized herein directed toward pathogen inhibition using metalloid/metallic oxide bactericides/fungicides nanofertilizers to enhance health. The is also reviewed. As global demand food production escalates against a changing climate, could sustainably mitigate many challenges by reducing chemical inputs promoting rapid detection pathogens.

Language: Английский

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Two‐Dimensional Antimonene‐Based Photonic Nanomedicine for Cancer Theranostics

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(38)

Published: July 24, 2018

Antimonene (AM) is a recently described two-dimensional (2D) elemental layered material. In this study, novel photonic drug-delivery platform based on 2D PEGylated AM nanosheets (NSs) developed. The platform's multiple advantages include: i) excellent photothermal properties, ii) high drug-loading capacity, iii) spatiotemporally controlled drug release triggered by near-infrared (NIR) light and moderate acidic pH, iv) superior accumulation at tumor sites, v) deep penetration both extrinsic stimuli (i.e., NIR light) intrinsic pH), vi) multimodal-imaging vii) significant inhibition of growth with no observable side effects potential degradability, thus addressing several key limitations cancer nanomedicines. intracellular fate the prepared NSs also revealed for first time, providing insights that improve cellular-level understanding nano-bio interactions AM-based other emerging nanomaterials. To best knowledge, report platforms, possibly marking an exciting jumping-off point research into application nanomaterials in theranostics.

Language: Английский

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Recent advances in magnetic fluid hyperthermia for cancer therapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2018, Volume and Issue: 174, P. 42 - 55

Published: Oct. 24, 2018

Language: Английский

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Molecular Probes for Autofluorescence-Free Optical Imaging

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(21), P. 13086 - 13131

Published: Sept. 24, 2021

Optical imaging is an indispensable tool in clinical diagnostics and fundamental biomedical research. Autofluorescence-free optical imaging, which eliminates real-time excitation to minimize background noise, enables clear visualization of biological architecture physiopathological events deep within living subjects. Molecular probes especially developed for autofluorescence-free have been proven remarkably improve the sensitivity, penetration depth, target specificity, multiplexing capability. In this Review, we focus on advancements molecular through lens particular or photophysical mechanisms that produce long-lasting luminescence after cessation light excitation. The versatile design strategies these are discussed along with a broad range applications. Finally, challenges perspectives further advance next-generation vivo vitro biosensors.

Language: Английский

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