Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(7), P. 2053 - 2108

Published: Sept. 27, 2018

The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis cancer, respectively. By taking advantage nanocarriers, both imaging therapeutic functions together with enhanced tumour accumulation have thoroughly studied to improve pre-clinical efficiency PAI PTT. In this review, we first summarize development inorganic organic nano photothermal transduction agents (PTAs) strategies improving PTT outcomes, including applying appropriate laser dosage, guiding via techniques, developing PTAs absorption in second NIR window, increasing (PCE), also tumours. Second, introduce advantages combining other therapies cancer treatment. Third, emerging applications cancer-related research are exemplified. Finally, perspectives challenges combating especially regarding their clinical translation, discussed. We believe that having noteworthy features would become promising next-generation non-invasive theranostic techniques our ability combat cancers.

Language: Английский

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Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(1), P. 38 - 71

Published: Nov. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Language: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

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Design of superior phototheranostic agents guided by Jablonski diagrams

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

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Optical nano-agents in the second near-infrared window for biomedical applications

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(1), P. 22 - 37

Published: Nov. 16, 2018

This review summarizes the recent advances of optical nano-agents for various biomedical applications in NIR-II window.

Language: Английский

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Photoluminescent and Chromic Nanomaterials for Anticounterfeiting Technologies: Recent Advances and Future Challenges

ACS Nano, Journal Year: 2020, Volume and Issue: 14(11), P. 14417 - 14492

Published: Oct. 20, 2020

Counterfeiting and inverse engineering of security confidential documents, such as banknotes, passports, national cards, certificates, valuable products, has significantly been increased, which is a major challenge for governments, companies, customers. From recent global reports published in 2017, the counterfeiting market was evaluated to be $107.26 billion 2016 forecasted reach $206.57 by 2021 at compound annual growth rate 14.0%. Development anticounterfeiting authentication technologies with multilevel securities powerful solution overcome this challenge. Stimuli-chromic (photochromic, hydrochromic, thermochromic) photoluminescent (fluorescent phosphorescent) compounds are most significant applicable materials development complex inks high-security level fast authentication. Highly efficient have developed high efficiency. Applicable applications generally based on photochromic compounds, hydrochromic thermochromic extensively used decades. A wide range materials, organic inorganic metal complexes, polymer nanoparticles, quantum dots, carbon upconverting supramolecular structures, could display all these phenomena depending their physical chemical characteristics. The polymeric recently received attention because stability printing documents. In addition, including hand-writing, stamping, inkjet printing, screen labels discussed introduction methods application different inks. This review would help scientists design develop encryption, authentication, security, detection, potential marking information encryption various substrates.

Language: Английский

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Near-Infrared Afterglow Luminescent Aggregation-Induced Emission Dots with Ultrahigh Tumor-to-Liver Signal Ratio for Promoted Image-Guided Cancer Surgery

Nano Letters, Journal Year: 2018, Volume and Issue: 19(1), P. 318 - 330

Published: Dec. 17, 2018

Afterglow imaging through the collection of persistent luminescence after stopping light excitation holds enormous promise for advanced biomedical uses. However, efficient near-infrared (NIR)-emitting afterglow luminescent materials and probes (particularly organic polymeric ones) are still very limited, their in-depth applications such as precise image-guided cancer surgery rarely reported. Here, we design synthesize a NIR nanoparticle with aggregation-induced emission (AIE) characteristics (named AGL AIE dots). It is demonstrated that dots emit rather-high persisting over 10 days single series processes occurring in dots, including singlet oxygen production by luminogens (AIEgens), Schaap's dioxetane formation, chemiexcitation decomposition, energy transfer to NIR-emitting AIEgens. The animal studies reveal have innate property fast signal quenching normal tissues, liver, spleen, kidney. After intravenous injection into peritoneal carcinomatosis bearing mice, tumor-to-liver ratio nearly 100-fold larger than fluorescence imaging. ultrahigh ratio, together low background noise, enables give excellent performance surgery.

Language: Английский

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Activatable Molecular Probes for Second Near‐Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(29), P. 11717 - 11731

Published: March 5, 2020

Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence biological tissue between 650-900 nm, conventional optical often has poor signal-to-background ratio shallow penetration depth, which limits its ability deep-tissue vivo imaging. Second near-infrared fluorescence, chemiluminescence, photoacoustic modalities mitigate these issues by their respective advantages of minimized scattering, eliminated external excitation, ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the change second or signals response biomarker have been developed. This Minireview summarizes design strategies, sensing mechanisms, applications AMPs. The potential challenges perspectives AMPs are also discussed.

Language: Английский

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Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy

Small, Journal Year: 2018, Volume and Issue: 15(1)

Published: Nov. 20, 2018

Abstract Phototherapy including photothermal therapy (PTT) and photodynamic (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional include easy recognition immune system, rapid clearance from blood circulation, low accumulation in target sites. Cell‐membrane coating emerged as a potential way overcome these limitations, owing abundant proteins on surface of cell membranes that can be inherited membrane–camouflaged nanoparticles. This review summarizes recent advances development biomimetic nanoparticles phototherapy. Different sources used coat uisng different approaches. After cell‐membrane coating, photophysical properties original remain nearly unchanged; however, coated are equipped with additional physiological features escape, vivo prolonged circulation time, homologous targeting, depending sources. Moreover, membrane ablated under laser irradiation, leading drug release thus synergetic By combining other supplementary normalize tumor microenvironment, further enhance therapeutic efficacy against cancer.

Language: Английский

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Chemiluminescence for bioimaging and therapeutics: recent advances and challenges

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(19), P. 6800 - 6815

Published: Jan. 1, 2020

The current progress, design principles in bioimaging and therapeutic applications, future perspectives of various chemiluminescent platforms are reviewed.

Language: Английский

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