Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 6850 - 6918

Published: March 2, 2022

Photoacoustic (PA) imaging technology, a three-dimensional hybrid modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular due to its high depth resolution. To endow PA with ability for real-time visualization precise biomedical diagnosis, numerous activatable probes which can specifically alter their intensities upon reacting targets or biological events interest have been developed. This review highlights recent developments applications including detection biotargets events. First, generation mechanism signals will be given, followed by brief introduction contrast agents used probe design. Then we particularly summarize general design principles alteration strategies developing probes. Furthermore, give detailed discussion living systems. At last, current challenges outlooks future discussed. We hope this stimulate new ideas explore potentials future.

Language: Английский

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Nitric Oxide-Activated “Dual-Key–One-Lock” Nanoprobe for in Vivo Molecular Imaging and High-Specificity Cancer Therapy

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(34), P. 13572 - 13581

Published: Aug. 1, 2019

Cancer treatments are confounded by severe toxic effects toward patients. To address these issues, activatable nanoprobes have been designed for specific imaging and destruction of cancer cells under the stimulation cancer-associated biomarkers. Most were usually activated some single-factor stimulation, but this restricts therapeutic specificity between diseased normal tissue; therefore, multifactor activation is highly desired. end, we herein develop a novel dual-stimuli responsive theranostic nanoprobe simultaneously photothermal therapy coactivation "dual-key" "nitric oxide (NO)/acidity", so as to further improve specificity. Specifically, integrated weak electron acceptor (benzo[c][1,2,5]thiadiazole-5,6-diamine) into donor−π-acceptor−π-donor type chromophore. When was oxidized NO in acidic conditions form stronger (5H-[1,2,3]triazolo[4,5-f]-2,1,3-benzothiadiazole), molecule absorption significantly increased near-infrared region, based on intramolecular charge transfer (ICT) mechanism. Under dual-key NO/acidity within tumor associated with inflammation, can correspondingly output dual signals ratiometric photoacoustic vivo do enhanced accuracy Our exhibited higher signal enhancement dual-factor at 9.8 times that 132 acidity alone, respectively. Moreover, through such NO/acidity, produces more differentiation hyperthermia tissues, afford satisfactory minimal side effects. Thus, our work presents promising strategy improving precision therapy.

Language: Английский

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Optical Multiplexed Bioassays for Improved Biomedical Diagnostics

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(38), P. 13208 - 13219

Published: April 17, 2019

Conventional analytical methods based on the detection of a single disease marker may not be sufficiently accurate because progression generally involves multiple chemicals and biomolecules. The drive for simultaneous analysis targets, which plays key role in both basic biomedical research clinical applications, demands development multiplexed bioassays with high-throughput. In this minireview, we summarize recent progress optical techniques improving diagnostics, fluorescence surface enhanced Raman scattering (SERS) distinctive features are chosen as main readout signals. Focusing strategies field, selection contributions from biosensing analytes multicolor cellular tracking to vivo bioimaging highlighted. Finally, frame future challenges opportunities bioanalysis.

Language: Английский

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Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

Chemical Science, Journal Year: 2019, Volume and Issue: 10(36), P. 8348 - 8353

Published: Jan. 1, 2019

Theranostic nanoprobes (SYL NPs) prepared from a newly designed NIR-II fluorophore and FDA approved DSPE-mPEG5000 were well tolerated exhibited multifunctional potential in diagnosis (photoacoustic & fluorescence imaging) phototherapy animal models.

Language: Английский

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Tumor biomarkers for diagnosis, prognosis and targeted therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 20, 2024

Abstract Tumor biomarkers, the substances which are produced by tumors or body’s responses to during tumorigenesis and progression, have been demonstrated possess critical encouraging value in screening early diagnosis, prognosis prediction, recurrence detection, therapeutic efficacy monitoring of cancers. Over past decades, continuous progress has made exploring discovering novel, sensitive, specific, accurate tumor significantly promoted personalized medicine improved outcomes cancer patients, especially advances molecular biology technologies developed for detection biomarkers. Herein, we summarize discovery development including history conventional innovative used biomarker classification biomarkers based on tissue origins, application clinical management. In particular, highlight recent advancements biomarker-based anticancer-targeted therapies emerging as breakthroughs promising strategies. We also discuss limitations challenges that need be addressed provide insights perspectives turn into opportunities this field. Collectively, multiple emphasized review may guidance precision medicine, broaden horizons future research directions, expedite patients according their rather than organs origin.

Language: Английский

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