Wearable biosensors for healthcare monitoring

Nature Biotechnology, Journal Year: 2019, Volume and Issue: 37(4), P. 389 - 406

Published: Feb. 25, 2019

Language: Английский

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Electronic Skin: Recent Progress and Future Prospects for Skin‐Attachable Devices for Health Monitoring, Robotics, and Prosthetics

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(48)

Published: Sept. 19, 2019

Abstract Recent progress in electronic skin or e‐skin research is broadly reviewed, focusing on technologies needed three main applications: skin‐attachable electronics, robotics, and prosthetics. First, since will be exposed to prolonged stresses of various kinds needs conformally adhered irregularly shaped surfaces, materials with intrinsic stretchability self‐healing properties are great importance. Second, tactile sensing capability such as the detection pressure, strain, slip, force vector, temperature important for health monitoring attachable devices, enable object manipulation surrounding environment robotics For chemical electrophysiological wireless signal communication high significance fully gauge state users ensure user comfort. prosthetics, large‐area integration 3D surfaces a facile scalable manner critical. Furthermore, new processing strategies using neuromorphic devices efficiently process information parallel low power manner. neural interfacing electrodes These topics discussed, progress, current challenges, future prospects.

Language: Английский

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Bio-Integrated Wearable Systems: A Comprehensive Review

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 5461 - 5533

Published: Jan. 28, 2019

Bio-integrated wearable systems can measure a broad range of biophysical, biochemical, and environmental signals to provide critical insights into overall health status quantify human performance. Recent advances in material science, chemical analysis techniques, device designs, assembly methods form the foundations for uniquely differentiated type technology, characterized by noninvasive, intimate integration with soft, curved, time-dynamic surfaces body. This review summarizes latest this emerging field "bio-integrated" technologies comprehensive manner that connects fundamental developments chemistry, engineering sensing have potential widespread deployment societal benefit care. An introduction chemistries materials active components these contextualizes essential design considerations sensors associated platforms appear following sections. The subsequent content highlights most advanced biosensors, classified according their ability capture information. Additional sections feature schemes electrically powering strategies achieving fully integrated, wireless systems. concludes an overview key remaining challenges summary opportunities where chemistry will be critically important continued progress.

Language: Английский

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A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat

Nature Biotechnology, Journal Year: 2019, Volume and Issue: 38(2), P. 217 - 224

Published: Nov. 25, 2019

Language: Английский

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Flexible Electronics toward Wearable Sensing

Accounts of Chemical Research, Journal Year: 2019, Volume and Issue: 52(3), P. 523 - 533

Published: Feb. 15, 2019

ConspectusWearable sensors play a crucial role in realizing personalized medicine, as they can continuously collect data from the human body to capture meaningful health status changes time for preventive intervention. However, motion artifacts and mechanical mismatches between conventional rigid electronic materials soft skin often lead substantial sensor errors during epidermal measurement. Because of its unique properties such high flexibility conformability, flexible electronics enables natural interaction body. In this Account, we summarize our recent studies on design devices systems physical chemical monitoring. Material innovation, design, device fabrication, system integration, employed toward continuous noninvasive wearable sensing are discussed.A typically contains several key components, including substrate, active layer, interface layer. The inorganic-nanomaterials-based layer (prepared by transfer or solution process) is shown have good physicochemical properties, electron/hole mobility, strength. Flexible based printed transferred has great promise sensing. For example, integrating nanowire transistor array matrix conductive pressure-sensitive rubber tactile pressure mapping; tactile-pressure-sensitive e-skin organic light-emitting diodes be integrated instantaneous visualization. Such been applied patches monitor temperature, electrocardiograms, activities. addition, liquid metals could serve an attractive candidate because their excellent conductivity, flexibility, stretchability. Liquid-metal-enabled (based liquid–liquid heterojunctions embedded microchannels) utilized wide range physiological parameters (e.g., pulse temperature).Despite rapid growth technologies, there urgent need development that molecular retrieve more insightful information. We developed sweat-sensing platform real-time multiplexed perspiration analysis. An iontophoresis module sweat enable autonomous programmed extraction. A microfluidics-based was demonstrated sampling, sensing, rate Roll-to-roll gravure printing allows mass production high-performance at low cost. These dehydration monitoring, cystic fibrosis diagnosis, drug glucose monitoring.Future work field should focus designing robust accurately large-scale determine how measured information relates individual's specific conditions. Further research these directions, along with large sets collected via will significant impact future healthcare.

Language: Английский

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Recent Advances in Photoelectrochemical Sensing: From Engineered Photoactive Materials to Sensing Devices and Detection Modes

Analytical Chemistry, Journal Year: 2019, Volume and Issue: 92(1), P. 363 - 377

Published: Nov. 18, 2019

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTRecent Advances in Photoelectrochemical Sensing: From Engineered Photoactive Materials to Sensing Devices and Detection ModesJian ShuJian ShuKey Laboratory of Analytical Science for Food Safety Biology (MOE Fujian Province), State Key Photocatalysis on Energy Environment, Department Chemistry, Fuzhou University, 350108, People's Republic ChinaMore by Jian ShuView Biography Dianping Tang*Dianping TangKey China*Phone: +86-591-2286 6125. Fax: 6135. E-mail: [email protected]More TangView Biographyhttp://orcid.org/0000-0002-0134-3983Cite this: Anal. Chem. 2020, 92, 1, 363–377Publication Date (Web):November 18, 2019Publication History Published online18 November 2019Published inissue 7 January 2020https://pubs.acs.org/doi/10.1021/acs.analchem.9b04199https://doi.org/10.1021/acs.analchem.9b04199review-articleACS PublicationsCopyright © 2019 American Chemical SocietyRequest reuse permissionsArticle Views11779Altmetric-Citations634LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Heterojunctions,Materials,Photonics,Semiconductors,Sensors Get e-Alerts

Language: Английский

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Technology Roadmap for Flexible Sensors

ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5211 - 5295

Published: March 9, 2023

Humans rely increasingly on sensors to address grand challenges and improve quality of life in the era digitalization big data. For ubiquitous sensing, flexible are developed overcome limitations conventional rigid counterparts. Despite rapid advancement bench-side research over last decade, market adoption remains limited. To ease expedite their deployment, here, we identify bottlenecks hindering maturation propose promising solutions. We first analyze achieving satisfactory sensing performance for real-world applications then summarize issues compatible sensor-biology interfaces, followed by brief discussions powering connecting sensor networks. Issues en route commercialization sustainable growth sector also analyzed, highlighting environmental concerns emphasizing nontechnical such as business, regulatory, ethical considerations. Additionally, look at future intelligent sensors. In proposing a comprehensive roadmap, hope steer efforts towards common goals guide coordinated development strategies from disparate communities. Through collaborative efforts, scientific breakthroughs can be made sooner capitalized betterment humanity.

Language: Английский

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A Review of 3D Printing Technologies for Soft Polymer Materials

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(28)

Published: April 29, 2020

Abstract Soft polymer materials, which are similar to human tissues, have played critical roles in modern interdisciplinary research. Compared with conventional methods, 3D printing allows rapid prototyping and mass customization is ideal for processing soft materials. However, of materials still the early stages development facing many challenges including limited printable low resolution speed, poor functionalities. The present review aims summarize ideas address these challenges. It focuses on three points: 1) how develop make unprintable printable, 2) choose suitable methods improve resolution, 3) directly construct functional structures/systems printing. After a brief introduction this topic, mainstream technologies reviewed, an emphasis improving choosing techniques, developing multiple Moreover, state‐of‐the‐art advancements multimaterial summarized. Furthermore, revolutions brought about by applications biology highlighted. Finally, viewpoints future perspectives emerging field discussed.

Language: Английский

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Exploring the Trans‐Cleavage Activity of CRISPR‐Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(48), P. 17399 - 17405

Published: Oct. 1, 2019

An accurate, rapid, and cost-effective biosensor for the quantification of disease biomarkers is vital development early-diagnostic point-of-care systems. The recent discovery trans-cleavage property CRISPR type V effectors makes a potential high-accuracy bio-recognition tool. Herein, CRISPR-Cas12a (cpf1) based electrochemical (E-CRISPR) reported, which more portable than optical-transduction-based biosensors. Through optimizing in vitro activity Cas12a, E-CRIPSR was used to detect viral nucleic acids, including human papillomavirus 16 (HPV-16) parvovirus B19 (PB-19), with picomolar sensitivity. aptamer-based E-CRISPR cascade further designed detection transforming growth factor β1 (TGF-β1) protein clinical samples. As demonstrated, could enable portable, diagnostic

Language: Английский

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Biofuel-powered soft electronic skin with multiplexed and wireless sensing for human-machine interfaces

Science Robotics, Journal Year: 2020, Volume and Issue: 5(41)

Published: April 15, 2020

A flexible and fully biofuel-powered electronic skin enables continuous, multiplexed, multimodal wireless sensing.

Language: Английский

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