Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

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Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: April 20, 2020

Despite its growing promise in cancer treatment, ferrotherapy has low therapeutic efficacy due to compromised Fenton catalytic efficiency tumor milieu. We herein report a hybrid semiconducting nanozyme (HSN) with high photothermal conversion for photoacoustic (PA) imaging-guided second near-infrared ferrotherapy. HSN comprises an amphiphilic polymer as converter, PA emitter and iron-chelating catalyst. Upon photoirradiation, generates heat not only induce cytotoxicity but also enhance reaction. The increased ·OH generation promotes both ferroptosis apoptosis, oxidizes (42 nm) transforms it into tiny segments (1.7 elevated intratumoral permeability. non-invasive seamless synergism leads amplified effects including deep ablation depth (9 mm), reduced expression of metastasis-related proteins inhibition metastasis from primary distant organs. Thereby, our study provides generalized strategy compensate phototherapeutics complete regression.

Language: Английский

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Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer

Accounts of Chemical Research, Journal Year: 2020, Volume and Issue: 53(4), P. 752 - 762

Published: Feb. 6, 2020

Cancer therapy is routinely performed in the clinic to cure cancer and control its progression, wherein therapeutic agents are generally used. To reduce side effects, protherapeutic that can be activated by overexpressed biomarkers under development. However, these still face certain extent of off-target activation normal tissues, stimulating interest design external-stimuli activatable protherapeutics. In this regard, photoactivatable have been utilized for treatments. because intrinsic features photolabile moieties, most only respond ultraviolet-visible light, limiting their vivo applications. Thus, near-infrared (NIR) light with minimal phototoxicity increased tissue penetration highly desired.In Account, we summarize our semiconducting polymer nanomaterials (SPNs) as NIR treatment. SPNs transformed from π-conjugated polymers efficiently convert into heat or singlet oxygen (1O2). With photothermal photodynamic properties, directly used photomedicine serve transducers activate 1O2-responsive agents.The heat-activatable SPN-based developed loading conjugating (e.g., agonist, gene, enzyme). For instance, photothermally triggered release agonists specifically activates protein ion channels on cellular membrane, leading overinflux induced mitochondria dysfunction consequently apoptosis cells. Moreover, temperature-sensitive bromelain promote situ degradation collagens (the major components extracellular matrix), resulting an improved accumulation tumor tissues thus amplified outcome.The 1O2-activatable constructed through covalent conjugation caged via hypoxia- 1O2-cleavable linkers. Upon photoirradiation, consume generate 1O2, which leads (PDT), meanwhile breaks linkers on-demand molecules chemodrug, enzyme, inhibitor). Such remote applied induce DNA damage, ribonucleic acid degradation, inhibition biosynthesis, immune system tumors living animals. By synergizing PDT photoactivation those biological actions, effectively eliminate even fully inhibit metastasis.This Account highlights potential construction versatile protherapeutics treat at designated times locations high outcome precision.

Language: Английский

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Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: March 9, 2020

Abstract Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose molecular design philosophy explore pure fluorophores by manipulation effects twisted intramolecular charge transfer and aggregation-induced at morphological levels. An dye emitting up 1600 nm quantum yield 11.5% NIR-II region is developed. fluorescence blood vessels deeply-located intestinal tract live mice based on dyes achieved high clarity enhanced signal-to-background ratio. We hope this study will inspire further development evolution bio-imaging.

Language: Английский

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Room‐Temperature Phosphorescence Resonance Energy Transfer for Construction of Near‐Infrared Afterglow Imaging Agents

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(52)

Published: Nov. 11, 2020

Abstract Afterglow imaging that detects photons after cessation of optical excitation avoids tissue autofluorescence and thus possesses higher sensitivity than traditional fluorescence imaging. Purely organic molecules with room‐temperature phosphorescence (RTP) have emerged as a new library benign afterglow agents. However, most RTP luminogens only emit visible light shallow penetration, constraining their in vivo applications. This study presents an nanoprobe (mTPA‐N) emission the NIR range for Such probe is composed molecule (mTPA) phosphorescent generator NIR‐fluorescent dye energy acceptor to enable resonance transfer (RT‐PRET), ultimately resulting redshifted at 780 nm. Because elimination background noise luminescence biologically transparent window, mTPA‐N permits lymph nodes living mice high signal‐to‐noise ratio. opens up universal approach develop into agents via construction RT‐PRET.

Language: Английский

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Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Small, Journal Year: 2021, Volume and Issue: 17(12)

Published: Feb. 12, 2021

Abstract Nanotechnology has provided great opportunities for managing neoplastic conditions at various levels, from preventive and diagnostic to therapeutic fields. However, when it comes clinical application, nanoparticles (NPs) have some limitations in terms of biological stability, poor targeting, rapid clearance the body. Therefore, biomimetic approaches, utilizing immune cell membranes, are proposed solve these issues. For example, macrophage or neutrophil membrane coated NPs developed with ability interact tumor tissue suppress cancer progression metastasis. The functionality particles largely depends on surface proteins cells their preserved function during extraction coating process NPs. Proteins outer can render a wide range activities NPs, including prolonged blood circulation, remarkable competency recognizing antigens enhanced better cellular interactions, gradual drug release, reduced toxicity vivo. In this review, nano‐based systems cells‐derived membranous layers, detailed production process, applicability treatment discussed. addition, future perspectives challenges translation also presented.

Language: Английский

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Bioapplications of small molecule Aza-BODIPY: from rational structural design toin vivoinvestigations

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(21), P. 7533 - 7567

Published: Jan. 1, 2020

This review highlights the empirical design guidelines and photophysical property manipulation of Aza-BODIPY dyes latest advances in their bioapplications.

Language: Английский

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All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 29(31)

Published: May 23, 2019

Abstract Development of single near‐infrared (NIR) laser triggered phototheranostics for multimodal imaging guided combination therapy is highly desirable but still a big challenge. Herein, novel small‐molecule dye DPP‐BT designed and synthesized, which shows strong absorption in the first NIR window (NIR‐I) fluorescence emission second region (NIR‐II). Such not only acts as dual‐modal contrast agent NIR‐II photoacoustic (PA) imaging, also serves combined therapeutic photothermal (PTT) photodynamic (PDT). The all‐in‐one phototheranostic nanoparticles are constructed by encapsulating DPP‐BT, chemotherapy drug DOX, natural phase‐change materials with folic acid functionalized amphiphile. Notably, under irradiation, DOX can effectively release from such via NIR‐induced hyperthermia DPP‐BT. By intravenous injection into Hela tumor‐bearing mice, tumor size location be accurately observed fluorescence/PA imaging. From vitro vivo results, simultaneously present remarkable antitumor efficacy PTT/PDT/chemo therapy, laser. Overall, this work provides an innovative strategy to design construct nanoplatforms clinical phototheranostics.

Language: Английский

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Activatable NIR Fluorescence/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(26), P. 10331 - 10341

Published: June 7, 2019

Stimuli-responsive in situ self-assembly of small molecules to form nanostructures living subjects has produced promising tools for molecular imaging and tissue engineering. However, controlling the process simultaneously activate multimodality signals a small-molecule probe is challenging. In this paper, we rationally integrate fluorogenic reaction into enzyme-responsive design small-molecule-based activatable near-infrared (NIR) fluorescence magnetic resonance (MR) bimodal probes imaging. Using alkaline phosphatase (ALP) as model target, demonstrate that (P-CyFF-Gd) can be activated by endogenous ALP overexpressed on cell membranes, producing membrane-localized assembled nanoparticles (NPs) directly visualized cryo-SEM. Simultaneous enhancements NIR (>70-fold at 710 nm) r1 relaxivity (∼2.3-fold) enable real-time, high-sensitivity, high-spatial-resolution localization activity live tumor cells mice. P-CyFF-Gd also delineate orthotopic liver foci, facilitating efficient image-guided surgical resection tissues intraoperative This strategy combines via MRI promote imaging, which could applicable other vivo enzyme locations real time.

Language: Английский

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A Semiconducting Polymer Nano‐prodrug for Hypoxia‐Activated Photodynamic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(18), P. 5920 - 5924

Published: Feb. 22, 2019

Photodynamic therapy (PDT) holds great promise for cancer therapy; however, its efficacy is often compromised by tumor hypoxia. Herein, we report the synthesis of a semiconducting polymer nanoprodrug (SPNpd) that not only efficiently generates singlet oxygen (1 O2 ) under NIR photoirradiation but also specifically activates chemotherapeutic action in hypoxic microenvironment. SPNpd self-assembled from amphiphilic brush, which comprises light-responsive photodynamic backbone grafted with poly(ethylene glycol) and conjugated chemodrug through hypoxia-cleavable linkers. The well-defined compact nanostructure (30 nm) enables accumulation living mice. Owing to these features, exerts synergistic chemo-therapy, effectively inhibits growth xenograft mouse model. This study represents first hypoxia-activatable phototherapeutic polymeric prodrug system high potential therapy.

Language: Английский

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