Advanced Materials,
Journal Year:
2019,
Volume and Issue:
32(3)
Published: March 29, 2019
Abstract
On
the
basis
of
Jablonski
diagram,
photophysical
properties
optical
agents
are
highly
associated
with
biomedical
function
and
efficacy.
Herein,
focus
is
on
organic/polymer
recent
progress
in
main
strategies
for
regulating
their
to
achieve
superior
cancer
diagnosis/phototheranostics
applications
highlighted.
Both
approaches
nanoengineering
molecular
design,
which
can
lead
optimized
effectiveness
required
function,
discussed.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(1), P. 209 - 268
Published: Oct. 19, 2021
In
vivo
imaging
in
the
second
near-infrared
window
(NIR-II,
1000-1700
nm),
which
enables
us
to
look
deeply
into
living
subjects,
is
producing
marvelous
opportunities
for
biomedical
research
and
clinical
applications.
Very
recently,
there
has
been
an
upsurge
of
interdisciplinary
studies
focusing
on
developing
versatile
types
inorganic/organic
fluorophores
that
can
be
used
noninvasive
NIR-IIa/IIb
(NIR-IIa,
1300-1400
nm;
NIR-IIb,
1500-1700
nm)
with
near-zero
tissue
autofluorescence
deeper
penetration.
This
review
provides
overview
reports
published
date
design,
properties,
molecular
imaging,
theranostics
fluorophores.
First,
we
summarize
design
concepts
up-to-date
functional
biomaterials,
order
single-walled
carbon
nanotubes
(SWCNTs),
quantum
dots
(QDs),
rare-earth-doped
nanoparticles
(RENPs),
organic
(OFs).
Then,
these
novel
modalities
applications
brought
by
superior
fluorescent
properties
are
reviewed.
Finally,
challenges
perspectives
future
translation,
aiming
at
boosting
application
progress
NIR-IIa
NIR-IIb
technology
highlighted.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: April 20, 2020
Despite
its
growing
promise
in
cancer
treatment,
ferrotherapy
has
low
therapeutic
efficacy
due
to
compromised
Fenton
catalytic
efficiency
tumor
milieu.
We
herein
report
a
hybrid
semiconducting
nanozyme
(HSN)
with
high
photothermal
conversion
for
photoacoustic
(PA)
imaging-guided
second
near-infrared
ferrotherapy.
HSN
comprises
an
amphiphilic
polymer
as
converter,
PA
emitter
and
iron-chelating
catalyst.
Upon
photoirradiation,
generates
heat
not
only
induce
cytotoxicity
but
also
enhance
reaction.
The
increased
·OH
generation
promotes
both
ferroptosis
apoptosis,
oxidizes
(42
nm)
transforms
it
into
tiny
segments
(1.7
elevated
intratumoral
permeability.
non-invasive
seamless
synergism
leads
amplified
effects
including
deep
ablation
depth
(9
mm),
reduced
expression
of
metastasis-related
proteins
inhibition
metastasis
from
primary
distant
organs.
Thereby,
our
study
provides
generalized
strategy
compensate
phototherapeutics
complete
regression.
Accounts of Chemical Research,
Journal Year:
2020,
Volume and Issue:
53(4), P. 752 - 762
Published: Feb. 6, 2020
Cancer
therapy
is
routinely
performed
in
the
clinic
to
cure
cancer
and
control
its
progression,
wherein
therapeutic
agents
are
generally
used.
To
reduce
side
effects,
protherapeutic
that
can
be
activated
by
overexpressed
biomarkers
under
development.
However,
these
still
face
certain
extent
of
off-target
activation
normal
tissues,
stimulating
interest
design
external-stimuli
activatable
protherapeutics.
In
this
regard,
photoactivatable
have
been
utilized
for
treatments.
because
intrinsic
features
photolabile
moieties,
most
only
respond
ultraviolet-visible
light,
limiting
their
vivo
applications.
Thus,
near-infrared
(NIR)
light
with
minimal
phototoxicity
increased
tissue
penetration
highly
desired.In
Account,
we
summarize
our
semiconducting
polymer
nanomaterials
(SPNs)
as
NIR
treatment.
SPNs
transformed
from
π-conjugated
polymers
efficiently
convert
into
heat
or
singlet
oxygen
(1O2).
With
photothermal
photodynamic
properties,
directly
used
photomedicine
serve
transducers
activate
1O2-responsive
agents.The
heat-activatable
SPN-based
developed
loading
conjugating
(e.g.,
agonist,
gene,
enzyme).
For
instance,
photothermally
triggered
release
agonists
specifically
activates
protein
ion
channels
on
cellular
membrane,
leading
overinflux
induced
mitochondria
dysfunction
consequently
apoptosis
cells.
Moreover,
temperature-sensitive
bromelain
promote
situ
degradation
collagens
(the
major
components
extracellular
matrix),
resulting
an
improved
accumulation
tumor
tissues
thus
amplified
outcome.The
1O2-activatable
constructed
through
covalent
conjugation
caged
via
hypoxia-
1O2-cleavable
linkers.
Upon
photoirradiation,
consume
generate
1O2,
which
leads
(PDT),
meanwhile
breaks
linkers
on-demand
molecules
chemodrug,
enzyme,
inhibitor).
Such
remote
applied
induce
DNA
damage,
ribonucleic
acid
degradation,
inhibition
biosynthesis,
immune
system
tumors
living
animals.
By
synergizing
PDT
photoactivation
those
biological
actions,
effectively
eliminate
even
fully
inhibit
metastasis.This
Account
highlights
potential
construction
versatile
protherapeutics
treat
at
designated
times
locations
high
outcome
precision.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: March 9, 2020
Abstract
Fluorescence
imaging
in
near-infrared
IIb
(NIR-IIb,
1500–1700
nm)
spectrum
holds
a
great
promise
for
tissue
imaging.
While
few
inorganic
NIR-IIb
fluorescent
probes
have
been
reported,
their
organic
counterparts
are
still
rarely
developed,
possibly
due
to
the
shortage
of
efficient
materials
with
long
emission
wavelength.
Herein,
we
propose
molecular
design
philosophy
explore
pure
fluorophores
by
manipulation
effects
twisted
intramolecular
charge
transfer
and
aggregation-induced
at
morphological
levels.
An
dye
emitting
up
1600
nm
quantum
yield
11.5%
NIR-II
region
is
developed.
fluorescence
blood
vessels
deeply-located
intestinal
tract
live
mice
based
on
dyes
achieved
high
clarity
enhanced
signal-to-background
ratio.
We
hope
this
study
will
inspire
further
development
evolution
bio-imaging.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(52)
Published: Nov. 11, 2020
Abstract
Afterglow
imaging
that
detects
photons
after
cessation
of
optical
excitation
avoids
tissue
autofluorescence
and
thus
possesses
higher
sensitivity
than
traditional
fluorescence
imaging.
Purely
organic
molecules
with
room‐temperature
phosphorescence
(RTP)
have
emerged
as
a
new
library
benign
afterglow
agents.
However,
most
RTP
luminogens
only
emit
visible
light
shallow
penetration,
constraining
their
in
vivo
applications.
This
study
presents
an
nanoprobe
(mTPA‐N)
emission
the
NIR
range
for
Such
probe
is
composed
molecule
(mTPA)
phosphorescent
generator
NIR‐fluorescent
dye
energy
acceptor
to
enable
resonance
transfer
(RT‐PRET),
ultimately
resulting
redshifted
at
780
nm.
Because
elimination
background
noise
luminescence
biologically
transparent
window,
mTPA‐N
permits
lymph
nodes
living
mice
high
signal‐to‐noise
ratio.
opens
up
universal
approach
develop
into
agents
via
construction
RT‐PRET.
Small,
Journal Year:
2021,
Volume and Issue:
17(12)
Published: Feb. 12, 2021
Abstract
Nanotechnology
has
provided
great
opportunities
for
managing
neoplastic
conditions
at
various
levels,
from
preventive
and
diagnostic
to
therapeutic
fields.
However,
when
it
comes
clinical
application,
nanoparticles
(NPs)
have
some
limitations
in
terms
of
biological
stability,
poor
targeting,
rapid
clearance
the
body.
Therefore,
biomimetic
approaches,
utilizing
immune
cell
membranes,
are
proposed
solve
these
issues.
For
example,
macrophage
or
neutrophil
membrane
coated
NPs
developed
with
ability
interact
tumor
tissue
suppress
cancer
progression
metastasis.
The
functionality
particles
largely
depends
on
surface
proteins
cells
their
preserved
function
during
extraction
coating
process
NPs.
Proteins
outer
can
render
a
wide
range
activities
NPs,
including
prolonged
blood
circulation,
remarkable
competency
recognizing
antigens
enhanced
better
cellular
interactions,
gradual
drug
release,
reduced
toxicity
vivo.
In
this
review,
nano‐based
systems
cells‐derived
membranous
layers,
detailed
production
process,
applicability
treatment
discussed.
addition,
future
perspectives
challenges
translation
also
presented.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(21), P. 7533 - 7567
Published: Jan. 1, 2020
This
review
highlights
the
empirical
design
guidelines
and
photophysical
property
manipulation
of
Aza-BODIPY
dyes
latest
advances
in
their
bioapplications.
Advanced Functional Materials,
Journal Year:
2019,
Volume and Issue:
29(31)
Published: May 23, 2019
Abstract
Development
of
single
near‐infrared
(NIR)
laser
triggered
phototheranostics
for
multimodal
imaging
guided
combination
therapy
is
highly
desirable
but
still
a
big
challenge.
Herein,
novel
small‐molecule
dye
DPP‐BT
designed
and
synthesized,
which
shows
strong
absorption
in
the
first
NIR
window
(NIR‐I)
fluorescence
emission
second
region
(NIR‐II).
Such
not
only
acts
as
dual‐modal
contrast
agent
NIR‐II
photoacoustic
(PA)
imaging,
also
serves
combined
therapeutic
photothermal
(PTT)
photodynamic
(PDT).
The
all‐in‐one
phototheranostic
nanoparticles
are
constructed
by
encapsulating
DPP‐BT,
chemotherapy
drug
DOX,
natural
phase‐change
materials
with
folic
acid
functionalized
amphiphile.
Notably,
under
irradiation,
DOX
can
effectively
release
from
such
via
NIR‐induced
hyperthermia
DPP‐BT.
By
intravenous
injection
into
Hela
tumor‐bearing
mice,
tumor
size
location
be
accurately
observed
fluorescence/PA
imaging.
From
vitro
vivo
results,
simultaneously
present
remarkable
antitumor
efficacy
PTT/PDT/chemo
therapy,
laser.
Overall,
this
work
provides
an
innovative
strategy
to
design
construct
nanoplatforms
clinical
phototheranostics.
Journal of the American Chemical Society,
Journal Year:
2019,
Volume and Issue:
141(26), P. 10331 - 10341
Published: June 7, 2019
Stimuli-responsive
in
situ
self-assembly
of
small
molecules
to
form
nanostructures
living
subjects
has
produced
promising
tools
for
molecular
imaging
and
tissue
engineering.
However,
controlling
the
process
simultaneously
activate
multimodality
signals
a
small-molecule
probe
is
challenging.
In
this
paper,
we
rationally
integrate
fluorogenic
reaction
into
enzyme-responsive
design
small-molecule-based
activatable
near-infrared
(NIR)
fluorescence
magnetic
resonance
(MR)
bimodal
probes
imaging.
Using
alkaline
phosphatase
(ALP)
as
model
target,
demonstrate
that
(P-CyFF-Gd)
can
be
activated
by
endogenous
ALP
overexpressed
on
cell
membranes,
producing
membrane-localized
assembled
nanoparticles
(NPs)
directly
visualized
cryo-SEM.
Simultaneous
enhancements
NIR
(>70-fold
at
710
nm)
r1
relaxivity
(∼2.3-fold)
enable
real-time,
high-sensitivity,
high-spatial-resolution
localization
activity
live
tumor
cells
mice.
P-CyFF-Gd
also
delineate
orthotopic
liver
foci,
facilitating
efficient
image-guided
surgical
resection
tissues
intraoperative
This
strategy
combines
via
MRI
promote
imaging,
which
could
applicable
other
vivo
enzyme
locations
real
time.
Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
58(18), P. 5920 - 5924
Published: Feb. 22, 2019
Photodynamic
therapy
(PDT)
holds
great
promise
for
cancer
therapy;
however,
its
efficacy
is
often
compromised
by
tumor
hypoxia.
Herein,
we
report
the
synthesis
of
a
semiconducting
polymer
nanoprodrug
(SPNpd)
that
not
only
efficiently
generates
singlet
oxygen
(1
O2
)
under
NIR
photoirradiation
but
also
specifically
activates
chemotherapeutic
action
in
hypoxic
microenvironment.
SPNpd
self-assembled
from
amphiphilic
brush,
which
comprises
light-responsive
photodynamic
backbone
grafted
with
poly(ethylene
glycol)
and
conjugated
chemodrug
through
hypoxia-cleavable
linkers.
The
well-defined
compact
nanostructure
(30
nm)
enables
accumulation
living
mice.
Owing
to
these
features,
exerts
synergistic
chemo-therapy,
effectively
inhibits
growth
xenograft
mouse
model.
This
study
represents
first
hypoxia-activatable
phototherapeutic
polymeric
prodrug
system
high
potential
therapy.