Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

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Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(33), P. 15391 - 15402

Published: Aug. 10, 2022

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) using small-molecule dyes has high potential for clinical use. However, many NIR-II suffer from emission quenching effect and extremely low quantum yields (QYs) practical usage forms. The AIE strategy been successfully utilized to develop with donor–acceptor (D–A) structures acceptable QYs aggregate state, but there is still large room QY improvement. Here, we rationally designed a emissive dye named TPE-BBT its derivative (TPEO-BBT) by changing electron-donating triphenylamine unit tetraphenylethylene (TPE). Their nanoparticles exhibited ultrahigh relative of 31.5% 23.9% water, respectively. By an integrating sphere, absolute was measured be 1.8% water. Its crystals showed 10.4%, which highest value among organic small molecules reported so far. optimized D–A interaction higher rigidity state are believed two key factors QY. Finally, photoluminescence (PL) chemiluminescence (CL) bioimaging through successive CL resonance energy transfer Förster processes. realized excellent PL quality mouse blood vessels local arthrosis inflammation mice signal-to-background ratio 130. Thus, design presented here brings new possibilities development bright technologies.

Language: Английский

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Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 14, 2022

Although Ru(II)-based agents are expected to be promising candidates for substituting Pt-drug, their in vivo biomedical applications still limited by the short excitation/emission wavelengths and unsatisfactory therapeutic efficiency. Herein, we rationally design a Ru(II) metallacycle with excitation at 808 nm emission over 1000 nm, namely Ru1085, which holds deep optical penetration (up 6 mm) enhanced chemo-phototherapy activity. In vitro studies indicate that Ru1085 exhibits prominent cell uptake desirable anticancer capability against various cancer lines, especially cisplatin-resistant A549 cells. Further reveal induces mitochondria-mediated apoptosis along S G2/M phase cycle arrest. Finally, shows precise NIR-II fluorescence imaging guided long-term monitored tumor minimal side effects. We envision of long-wavelength emissive will offer emerging opportunities metal-based applications.

Language: Английский

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Anti‐Quenching NIR‐II J‐Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(20)

Published: March 3, 2023

Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used construct long-wavelength NIR-II emitters as optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, wide applications in fluorescence imaging impeded by limited varieties of J-type backbone serious quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) anti-quenching effect is reported highly efficient phototheranostics. The BT manipulated have Stokes shift over 400 nm aggregation-induced (AIE) property conquering self-quenching issue fluorophores. Upon BT6 assemblies an aqueous environment, absorption 800 1000 boosted more than 41 26 folds, respectively. In vivo visualization whole-body blood vessel imaging-guided phototherapy results verify that NPs agent cancer This work develops strategy precisely properties biomedical applications.

Language: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

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Long wavelength–emissive Ru(II) metallacycle–based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(32)

Published: Aug. 1, 2022

Ruthenium (Ru) complexes are developed as latent emissive photosensitizers for cancer and pathogen photodiagnosis therapy. Nevertheless, most existing Ru limited in terms of short excitation emission wavelengths. Herein, we present an Ru(II) metallacycle (herein referred to 1) that is excited by 808-nm laser emits at a wavelength ∼1,000 nm via coordination-driven self-assembly. Metallacycle 1 exhibits good optical penetration (∼7 mm) satisfactory reactive oxygen species production properties. Furthermore, shows broad-spectrum antibacterial activity (including against drug-resistant Escherichia coli) well low cytotoxicity normal mammalian cells. In vivo studies reveal employed precise, second near-infrared biomedical window fluorescent imaging-guided, photo-triggered treatments Staphylococcus aureus-infected mice models, with negligible side effects. This work thus broads the applications supramolecular through strategy lengthening their

Language: Английский

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Design of NIR-II high performance organic small molecule fluorescent probes and summary of their biomedical applications

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 468, P. 214609 - 214609

Published: May 31, 2022

Language: Английский

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Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821

Published: April 9, 2023

Language: Английский

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Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(13), P. 4392 - 4442

Published: Jan. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Language: Английский

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Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location aesthetic significance render breast cancer particularly pertinent candidate the clinical application of PTT following melanoma. This review comprehensively explores research conducted on various types nanoparticles employed elaborates their specific roles mechanisms action. integration existing therapies is scrutinized, underscoring its potential synergistic outcomes. Additionally, underlying consequential modifications to tumor microenvironment after are elaborated from medical perspective. Future directions suggested, an emphasis development integrative platforms that combine multiple therapeutic approaches optimization nanoparticle synthesis enhanced efficacy. goal push boundaries toward comprehensive, clinically applicable

Language: Английский

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