Progress of Improving Mechanical Strength of Electrospun Nanofibrous Membranes

Macromolecular Materials and Engineering, Journal Year: 2020, Volume and Issue: 305(11)

Published: Sept. 11, 2020

Abstract Electrospun nanofibers with superior performance have attracted widespread attention from researchers due to their extensive application in biomedical materials, filtration, catalysis, and so forth. However, the low mechanical properties, such as elongation at breaking strength tensile strength, restrict of many aspects. This article describes recent progress improving properties electrospun nanofibrous membranes. At present, methods increase are mainly based on introduction appropriate polymer improvements spinning parameters, post‐treatment. Herein, principle, advantages, disadvantages those depth described. Finally, research enhancing membranes future development is being discussed.

Language: Английский

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Hemostatic nanotechnologies for external and internal hemorrhage management

Biomaterials Science, Journal Year: 2020, Volume and Issue: 8(16), P. 4396 - 4412

Published: Jan. 1, 2020

An uncontrolled hemorrhage can easily lead to death during surgery and military operations. Despite the significant advances in hemostatic research, there is still an urgent increasing need for safer more effective materials. Recently, nanotechnologies have been receiving interest owing their unique advantages propelling developement of This review summarizes fundamentals hemostasis emphasizes recent developments regarding hemorrhage-related nanotechnologies. In terms external accessible management, natural synthetic polymers inorganic components that used traditional hemostats provide novel nanoscale solutions. Regarding internal noncompressible current research endeavors are dedicated development substitutes blood components, nanoformulated drugs. also briefly discusses main persistent problems nanomaterials, including safety concerns clinical translation challenges. hoped critical insight into nanomaterial development.

Language: Английский

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Mixed-Ligand Metal–Organic Frameworks for All-in-One Theranostics with Controlled Drug Delivery and Enhanced Photodynamic Therapy

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(23), P. 26528 - 26535

Published: May 31, 2022

Mixed-ligand metal–organic frameworks (MOFs) multiply the properties and improve versatility of conventional MOFs for theranostic applications. A tumor targeting tumoral microenvironment-responsive system is significant specific efficient cancer theranostics. Herein, we report a kind versatile mixed-porphyrin ligand MOF as multifunctional matrix multimodality-imaging-guided synergistic therapy. Tetrakis(4-carboxyphenyl)porphyrin (TCPP) shows fluorescence (FL) photodynamic therapy (PDT), while Mn-TCPP owns magically T1-weighted magnetic resonance (MR) imaging photothermal conversion (PTT). Because same coordination capacity mode TCPP to Zr4+ ions, with adjustable ratios were easily prepared. The mixed-ligand exhibited high drug loading 10-hydroxycamptothecin (HCPT, 65%). After modification hyaluronic acid (HA) through disulfide bond (−S–S−), MOF–S–S–HA composites possess enhanced PDT tumor-targeted redox-responsive release due −S–S– bond. Thus, excellent fluorescence, MR, trimodality imaging, release, PDT/PTT are integrated together in "all-in-one" agents.

Language: Английский

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Self‐Assembling Peptide‐Based Functional Biomaterials

ChemBioChem, Journal Year: 2022, Volume and Issue: 24(2)

Published: Nov. 8, 2022

Peptides can self-assemble into various hierarchical nanostructures through noncovalent interactions and form functional materials exhibiting excellent chemical physical properties, which have broad applications in bio-/nanotechnology. The self-assembly mechanism, morphology of peptide supramolecular architecture their applications, been widely explored the merit biocompatibility, easy preparation, controllable functionality. Herein, we introduce latest research progress self-assembling peptide-based nanomaterials review biomedicine optoelectronics, including tissue engineering, anticancer therapy, biomimetic catalysis, energy harvesting. We believe that this will inspire rational design development novel bio-inspired future.

Language: Английский

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In Situ Self-Sorting Peptide Assemblies in Living Cells for Simultaneous Organelle Targeting

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(21), P. 9312 - 9323

Published: May 19, 2022

Self-sorting is a common phenomenon in eukaryotic cells and represents one of the versatile strategies for formation advanced functional materials; however, developing artificial self-sorting assemblies within living remains challenging. Here, we report on GSH-responsive situ peptide cancer simultaneous organelle targeting to promote combinatorial dysfunction thereby cell death. The system was created via design two peptides E3C16E6 EVMSeO derived from lipid-inspired interdigitating amphiphiles bola-amphiphiles, respectively. distinct organization patterns facilitate their GSH-induced into isolated nanofibrils as result cleavage disulfide-connected hydrophilic domains or reduction selenoxide groups. HeLa directly characterized by super-resolution structured illumination microscopy. Incorporation thiol ER-targeting groups self-sorted endows endoplasmic reticulum Golgi apparatus, thus leading Our results demonstrate establishment cells, providing unique platform drug delivery an alternative strategy modulating biological processes future.

Language: Английский

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