Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 328, P. 251 - 262

Published: Sept. 1, 2020

Language: Английский

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Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(3)

Published: Jan. 5, 2021

Phototherapy such as photothermal therapy and photodynamic in cancer treatment has been developed quickly over the past few years for its noninvasive nature high efficiency. However, there are still many drawbacks phototherapy that prevent it from clinical applications. Thus, scientists have designed different systems to overcome issues associated with phototherapy, including enhancing targeting ability of low-temperature therapy, replacing near-infrared light other excitation sources, so on. This article discusses problems shortcomings encountered development highlights possible solutions address them may become a useful approach practice. aims give brief summary about current research advancements provides quick guideline toward future developments field.

Language: Английский

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Precise Molecular Design for High‐Performance Luminogens with Aggregation‐Induced Emission

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(1)

Published: Oct. 3, 2019

Precise design of fluorescent molecules with desired properties has enabled the rapid development many research fields. Among different types optically active materials, luminogens aggregation-induced emission (AIEgens) have attracted significant interest over past two decades. The negligible luminescence AIEgens as a molecular species and high brightness in aggregate states distinguish them from conventional dyes, which galvanized efforts to bring wide array multidisciplinary applications. Herein, useful principles emerging structure-property relationships for precise toward desirable using concrete examples are revealed. cutting-edge applications their excellent performance enabling new directions biomedical theranostics, optoelectronic devices, stimuli-responsive smart visualization physical processes also highlighted.

Language: Английский

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Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy

Nano Letters, Journal Year: 2019, Volume and Issue: 19(6), P. 4134 - 4145

Published: May 14, 2019

As a noninvasive treatment modality, ultrasound (US)-triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic (PDT) in combating cancer. However, SDT efficacy is still not satisfactory without oxygen (O2) assistance. In addition, there also much space explore SDT-based synergistic therapeutic modalities. Herein, novel Pt-CuS Janus composed hollow semiconductor CuS noble metallic Pt was rationally designed successfully synthesized. The large inner cavity for loading sonosensitizer molecules (tetra-(4-aminophenyl) porphyrin, TAPP) implement SDT. Moreover, deposition only enhances photothermal performance compared with those nanoparticles (NPs) due effect local electric field enhancement but possesses nanozyme activity catalyzing decomposition endogenous overexpressed hydrogen peroxide (H2O2) produce O2 that can tumor hypoxia augment SDT-induced highly toxic reactive species (ROS) production efficient cancer cell apoptosis. Importantly, generated heat by 808 nm laser irradiation accelerate catalytic elevate level further facilitates efficacy. Interestingly, thermally sensitive copolymer coated around act as smart switch regulate ability control TAPP release has significant on modulating effect. catalysis-enhanced efficiency almost realized complete resection obvious reoccurrence simultaneously displayed biosafety. Furthermore, high optical absorbance allows as-synthesized photoacoustic (PA) imaging NIR thermal imaging. This work develops versatile nanoplatform multifunctional theranostic strategy broadens biological designing their structure.

Language: Английский

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Trends in Micro‐/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 4, 2020

Abstract Micro‐/nanorobots (m‐bots) have attracted significant interest due to their suitability for applications in biomedical engineering and environmental remediation. Particularly, vivo diagnosis intervention been the focus of extensive research recent years with various clinical imaging techniques being applied localization tracking. The successful integration well‐designed m‐bots surface functionalization, remote actuation systems, becomes crucial step toward applications, especially uses. This review thus addresses four different aspects m‐bots: design/fabrication, actuation, localization. diagnosis, sensing, microsurgery, targeted drug/cell delivery, thrombus ablation, wound healing are reviewed from these viewpoints. developed m‐bot systems comprehensively compared evaluated based on characteristics. current challenges directions future this field summarized.

Language: Английский

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The recent progress on metal–organic frameworks for phototherapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(8), P. 5086 - 5125

Published: Jan. 1, 2021

Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over world. The commonly used antibiotic therapy cannot effectively treat these within a short time, and also bring about adverse effects drug resistance immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) induce temperature increase, which leads death targeted cells. These two kinds killing strategies referred photodynamic (PDT) photothermal (PTT), respectively. So far, many photo-responsive have been developed. Among them, metal-organic framework (MOF) becoming one most promising materials because its structure chemical compositions be easily modulated achieve specific functions. MOFs intrinsic ability under rational design MOF construction, serve carrier therapeutic agents, owing tunable porosity. provide feasibility for various combined therapies targeting methods, improves efficiency phototherapy. In this review, we firstly investigated principles phototherapy, comprehensively summarized recent advances in PDT, PTT synergistic therapy, from construction modification. We expect that our demonstration will shed on future development field, it step closer clinical trials.

Language: Английский

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An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(36)

Published: July 21, 2020

Abstract Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, optimum use dissipated energy through both radiative nonradiative pathways is definitely appealing, yet a significantly challenging task. To best knowledge, there have been no previous reports on single molecular species effective at affording all phototheranostic modalities including fluorescence (FLI), photoacoustic (PAI), photothermal (PTI), photodynamic therapy (PDT), (PTT). Herein, simple highly powerful one‐for‐all based aggregation‐induced emission (AIE)‐active fluorophores tactfully designed constructed. Thanks its strong electron donor–acceptor interaction finely modulated intramolecular motion, AIE fluorophore‐based nanoparticles simultaneously exhibit bright near‐infrared II (NIR‐II) emission, efficient reactive oxygen generation, high conversion efficiency upon NIR irradiation, indicating actualization balance between dissipations. Furthermore, unprecedented performance NIR‐II FLI‐PAI‐PTI trimodal‐imaging‐guided PDT–PTT demonstrated by precise tumor diagnosis complete elimination outcomes. This study thus brings new insight into development superior for practical cancer theranostics.

Language: Английский

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Recent advances in nanomaterials for enhanced photothermal therapy of tumors

Nanoscale, Journal Year: 2018, Volume and Issue: 10(48), P. 22657 - 22672

Published: Jan. 1, 2018

Recent advances in nanomaterials for enhanced therapeutic efficacy of photothermal therapy tumor treatment were highlighted.

Language: Английский

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Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Language: Английский

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