The Chemical Record,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
The
hunt
for
new
molecular
structures
to
improve
the
efficacy
of
biologically
active
molecules
is
at
forefront
pharmaceutical
chemistry.
So
synthetic
chemists
have
always
been
busy
in
last
few
decades
synthesizing
and
testing
frameworks
which
would
work
as
more
efficient
bioisosteres
present
bioactive
functional
groups.
In
this
area,
bicyclo[1.1.1]pentane
(BCP)
framework
has
identified
a
promising
candidate.
It
being
utilized
bioisostere
aryl,
tert-butyl,
alkynes,
etc.
Now
major
precursor
various
BCP
derivatives
[1.1.1]propellane
functionalization
drawn
widespread
attention
organic
chemist
community.
Over
past
two
decades,
use
visible
light
synthesis
rapidly
gained
popularity,
it
represents
one
most
approaches
aligned
with
principles
green
sustainable
chemistry,
several
interesting
papers
covering
photocatalytic
difunctionalization
also
published
decade.
This
particular
field
really
attracted
That
why
we
decided
compile
review
article
articles
related
under
conditions.
Here
review,
categorized
discussed
three
categories,
namely
i)
without
using
any
catalyst,
ii)
organocatalysts,
iii)
metal
catalysts
deeper
understanding
key
aspects
these
transformations.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 10, 2024
Abstract
Bioisosteric
design
has
become
an
essential
approach
in
the
development
of
drug
molecules.
Recent
advancements
synthetic
methodologies
have
enabled
rapid
adoption
this
strategy
into
discovery
programs.
Consequently,
conceptionally
innovative
practices
would
be
appreciated
by
medicinal
chemistry
community.
Here
we
report
expeditous
method
for
synthesizing
aryl
difluoromethyl
bicyclopentane
(ADB)
as
a
bioisostere
benzophenone
core.
This
involves
merger
light-driven
C−F
bond
activation
and
strain-release
under
catalysis
newly
designed
N
-anionic-based
organic
photocatalyst.
defluorinative
coupling
methodology
enables
direct
conversion
wide
variety
commercially
available
trifluoromethylaromatic
bonds
(more
than
70
examples)
corresponding
bicyclo[1.1.1]pentanes
(BCP)
arenes/difluoromethyl
BCP
boronates
single
step.
The
can
also
applied
to
[3.1.1]and
[4.1.1]propellane
systems,
providing
access
analogues
with
different
geometries.
Moreover,
successfully
used
protocol
rapidly
prepare
ADB-substituted
bioactive
molecule
Adiporon.
Biological
testing
shown
that
ADB
scaffold
potential
enhance
pharmacological
properties
benzophenone-type
candidates.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 31, 2024
Bridged
cyclobutanes
and
sulfur
heterocycles
are
currently
under
intense
investigation
as
building
blocks
for
pharmaceutical
drug
design.
Two
formal
cycloaddition
modes
involving
bicyclobutanes
(BCBs)
pyridinium
1,4-zwitterionic
thiolate
derivatives
were
described
to
rapidly
expand
the
chemical
space
of
sulfur-containing
bridged
cyclobutanes.
By
using
Ni(ClO
Biomolecules,
Journal Year:
2020,
Volume and Issue:
10(8), P. 1111 - 1111
Published: July 27, 2020
The
concept
of
a
scaffold
concerns
many
aspects
at
different
steps
on
the
drug
development
path.
In
medicinal
chemistry,
choice
relevant
“drug-likeness”
is
starting
point
for
design
structure
dedicated
to
specific
molecular
targets.
For
years,
chemical
uniqueness
stilbene
has
inspired
scientists
from
fields
such
as
biology,
pharmacy,
and
medicine.
this
review,
we
present
outstanding
potential
stilbene-based
derivatives.
Naturally
occurring
stilbenes,
together
with
powerful
synthetic
chemistry
possibilities,
may
offer
an
excellent
approach
discovering
new
structures
identifying
their
therapeutic
With
scientific
tools,
sophisticated
equipment,
better
understanding
disease
pathogenesis
level,
moved
innovation
in
science.
This
paper
mainly
focuses
compounds
beyond
resveratrol,
which
are
particularly
attractive
due
biological
activity.
Given
“fresh
outlook”
about
stilbenoids
particular
regard
isorhapontigenin
methoxy-
hydroxyl-
analogues,
update
combretastatins,
very
often
overlooked
underestimated
benzanilide
story
remarkable
structure.
Science Advances,
Journal Year:
2020,
Volume and Issue:
6(46)
Published: Nov. 13, 2020
Super-soft
elastomers
derived
from
bottlebrush
polymers
show
promise
as
advanced
materials
for
biomimetic
tissue
and
device
applications,
but
current
processing
strategies
are
restricted
to
simple
molding.
Here,
we
introduce
a
design
concept
that
enables
the
three-dimensional
(3D)
printing
of
super-soft
solvent-free
at
room
temperature.
The
key
advance
is
class
inks
comprising
statistical
self-assemble
into
well-ordered
body-centered
cubic
sphere
phases.
These
soft
solids
undergo
sharp
reversible
yielding
20°C
in
response
shear
with
yield
stress
can
be
tuned
by
manipulating
length
scale
microphase
separation.
addition
soluble
photocrosslinker
allows
complete
ultraviolet
curing
after
extrusion
form
near-perfect
recoverable
elasticity
well
beyond
strain.
structure-property
rules
create
exciting
opportunities
tailor
performance
3D-printed
ways
not
possible
processes.
The Science of The Total Environment,
Journal Year:
2023,
Volume and Issue:
875, P. 162461 - 162461
Published: March 1, 2023
Since
ancient
times,
breastfeeding
has
been
the
fundamental
way
of
nurturing
newborn.
The
benefits
breast
milk
are
widely
known,
as
it
is
a
source
essential
nutrients
and
provides
immunological
protection,
well
developmental
benefits,
among
others.
However,
when
not
possible,
infant
formula
most
appropriate
alternative.
Its
composition
meets
nutritional
requirements
infant,
its
quality
subject
to
strict
control
by
authorities.
Nonetheless,
presence
different
pollutants
detected
in
both
matrices.
Thus,
aim
present
review
make
comparison
between
findings
terms
contaminants
last
decade,
order
choose
convenient
option
depending
on
environmental
conditions.
For
that,
emerging
including
metals,
chemical
compounds
derived
from
heat
treatment,
pharmaceutical
drugs,
mycotoxins,
pesticides,
packaging
materials,
other
were
described.
While
concerning
found
metals
such
materials
outstanding.
In
conclusion,
convenience
using
feeding
diet
based
or
either
depends
maternal
circumstances.
important
take
into
account
compared
formula,
possibility
combination
with
fulfilled
only
intake
milk.
Therefore,
more
attention
should
be
paid
analyzing
these
conditions
each
case
able
proper
decision,
will
vary
newborn
environment.
Eco-Environment & Health,
Journal Year:
2023,
Volume and Issue:
3(1), P. 30 - 44
Published: Oct. 19, 2023
Benzophenone
ultraviolet
light
filters
(BPs)
are
high-production-volume
chemicals
extensively
used
in
personal
care
products,
leading
to
widespread
human
exposure.
Given
their
estrogenic
properties,
the
potential
health
risks
associated
with
exposure
BPs
have
become
a
public
concern.
This
review
aims
summarize
sources
and
pathways
of
risks.
Dermal
exposure,
primarily
through
use
sunscreens,
constitutes
major
pathway
for
BP
At
recommended
application
rate,
dermal
BP-3
via
sunscreens
may
reach
or
exceed
suggested
reference
dose.
Other
BPs,
such
as
drinking
water,
seafood,
packaged
foods,
contribute
minimal
overall
Inhalation
is
minor
exposure;
however,
its
contribution
cannot
be
ignored.
Human
an
order
magnitude
higher
North
America
than
Asia
Europe.
Studies
conducted
on
laboratory
animals
cells
consistently
demonstrated
toxic
effects
elicit
reproductive
developmental
toxicities.
Furthermore,
neurotoxicity,
hepatotoxicity,
nephrotoxicity,
carcinogenicity
been
reported
from
chronic
In
addition
animal
cell
studies,
epidemiological
investigations
identified
associations
between
couples'
fecundity
other
disorders,
well
adverse
birth
outcomes.
Further
studies
urgently
needed
understand
posed
by
health.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(12), P. 2162 - 2166
Published: March 21, 2023
The
development
of
mild
methodology
for
converting
inert
C-H
bonds
to
value-added
molecules
has
been
an
attractive
research
topic
during
the
last
few
decades
as
it
offers
efficient
preparation.
Meanwhile,
diaryl
ketones
hold
potent
applications
in
antitumor
drugs,
agrochemical
industry,
and
synthetic
chemistry.
Herein,
we
report
versatile
palladium-catalyzed
carbonylative
cross-coupling
reactions
aryl
thianthrenium
salts
with
arylboronic
acids.
Arenes
were
transformed
site
selectively
via
C(sp2)-H
thianthrenation,
various
desired
produced
good
excellent
yields.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(10), P. 3909 - 3915
Published: Jan. 1, 2023
Visible
light-induced
highly
efficient
synthesis
of
1,3-disubstituted
bicyclo[1.1.1]pentane
with
mild
conditions,
high
atom
economy,
and
superior
functional
group
tolerance.
Journal of Coordination Chemistry,
Journal Year:
2024,
Volume and Issue:
77(12-14), P. 1324 - 1348
Published: July 15, 2024
Carbonylative
Suzuki–Miyaura
coupling
is
an
attractive
and
efficient
strategy
for
preparation
of
diaryl
ketones.
reactions
are
difficult
palladium
complexes
popular
catalysts.
The
use
as
catalysts
allows
the
reaction
to
be
carried
out
under
milder
conditions
ketone
products
prepared
with
good
high
yields.
nanocatalysts
has
become
effective
performing
complex
especially
carbonylative
because
have
characteristics
both
homogeneous
heterogeneous
catalytic
systems.
In
this
review,
we
study
application
ketones
through
aryl
halides,
arylboronic
acids
carbonyl
sources.
Based
on
internet
code
survey
research,
paper
first
review
in
reactions.
We
believe
will
a
valuable
source
chemists
working
field
or
