Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111960 - 111960
Published: July 5, 2024
Language: Английский
Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: March 1, 2024
Non-alcoholic fatty liver disease (NAFLD) is a common chronic with an increasing incidence worldwide. Single drug therapy may have toxic side effects and disrupt gut microbiota balance. Polyphenols are widely used in intervention due to their distinctive nutritional properties medicinal value, which potential modulator. However, there lack of comprehensive review explore the efficacy mechanism combined drugs polyphenols for NAFLD. Based on this, this firstly discusses link between NAFLD microbiota, outlines microbiota. Secondly, it examined recent advances treatment therapeutic effect combination two. Finally, we highlight underlying mechanisms polyphenol This mainly terms signaling pathways (NF-κB, AMPK, Nrf2, JAK/STAT, PPAR, SREBP-1c, PI3K/Akt TLR) Furthermore, some emerging such as microRNA biomarker therapies provide avenues Drawing inspiration from strategies, use active substances holds transformative prospective potential, both improve restore balance while reducing required dosage. systematically bidirectional interactions NAFLD, summarizes synergistic by modulating Future researches should develop multi-omics technology identify patients who benefit devising individualized plans enhance its effect.
Language: Английский
Citations
21
RSC Chemical Biology, Journal Year: 2022, Volume and Issue: 3(6), P. 614 - 647
Published: Jan. 1, 2022
Laccases are green biocatalysts to synthesise compounds with therapeutic value.
Language: Английский
Citations
57
Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(8), P. 957 - 957
Published: Aug. 1, 2022
Resveratrol (RVT) is a well known phyto-chemical and widely used in dietary supplements botanical products. It shows wide range of pharmacological/beneficial effects. Therefore, it can be potential candidate to developed as phyto-pharmaceutical. Multiple diseases are reported treated by the therapeutic effect RVT since has antioxidant, anti-cancer activity anti-inflammatory activities. also major role diabetes, arthritis, cardiac disorder platelet aggregation etc. The requirements establishments regarding safety, efficacy profile physicochemical characterization. As already being consumed variable maximum daily dose, there should not safety concern but dose needs established for different indications. Clinical trials parts world. Physicochemical properties moiety reported. Moreover, due its beneficial on health leads development some intellectual property form patents.
Language: Английский
Citations
41
Science China Life Sciences, Journal Year: 2022, Volume and Issue: 66(7), P. 1518 - 1534
Published: Dec. 28, 2022
Language: Английский
Citations
39
Plants, Journal Year: 2023, Volume and Issue: 12(16), P. 2935 - 2935
Published: Aug. 14, 2023
The use of natural compounds as an alternative to synthetic molecules has become a significant subject interest in recent decades. Stilbenoids are group phenolic found many plant species and they have recently gained the focus multitude studies medicine chemistry, resveratrol being most representative molecule. In this review, we focused on research that illustrates therapeutic potential class considering various diseases with higher incidence rates. PubChem database was searched for bioactivities stilbenoids, while several keywords (i.e., “stilbenoids”, “stilbenoid anticancer”) were used query PubMed relevant studies. diversity simplicity stilbenes’ chemical structures together numerous biological sources key elements can simplify both isolation these drug design novel bioactive molecules. Resveratrol other related heterogeneously distributed plants mainly grapes wine. Natural stilbenes shown possess wide range activities, such antioxidant, anti-inflammatory, antihyperglycemic, cardioprotective, neuroprotective, antineoplastic properties. While is widely investigated its benefits disorders, further warranted properly harness less popular stilbenoid compounds.
Language: Английский
Citations
37
Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 3, P. 100539 - 100539
Published: Nov. 21, 2023
Oxidative stress has a significant impact on the occurrence of many chronic diseases. Antioxidants have ability to prevent, postpone or treat effects free radicals. Resveratrol is polyphenol from class stilbenes. The importance this compound determined by its numerous biological properties. strong antioxidant potential special significance, because way it acts in prevention and treatment action direct, inhibiting production reactive species, indirect, influencing activity enzymes. In case analyzing known methods, was observed that RSV had higher capacity than standard used. Also, vitro vivo studies demonstrate neurodegenerative, cardiovascular renal addition, active preeclampsia infertility. An important aspect fact reduce counteract adverse some anticancer agents.
Language: Английский
Citations
30
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Based on molecular networking-guided isolation, 15 previously undescribed hydrogenated phenanthrene glycosides, including eight hexahydro-phenanthrenone four tetrahydro-phenanthrenone one dihydro-phenanthrenol glycoside, two dimers, and known dihydrophenanthrene were isolated from
Language: Английский
Citations
1
Journal of Food Biochemistry, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Resveratrol (RES) is a nonflavonoid polyphenolic compound present in various plant species. Extensive research has confirmed the diverse biological activities of RES, rendering it highly promising for multiple industries. However, its stability influenced by intrinsic factors, such as structure, and extrinsic including light exposure, oxygen elevated temperature, pH variations. RES also faces challenges related to low solubility, rapid metabolism, limited bioavailability, which impede application food medical sectors. The objective this study was provide comprehensive overview most up‐to‐date advancements green efficient production pathways evaluate instability strategies stabilization. mainly achieved through extraction biosynthesis. methods include deep eutectic solvent (DES) methods, ultrasound‐assisted, supercritical fluid (SFE), enzyme‐assisted technology. advantages disadvantages each method are compared paper. biosynthesis can produce high yield short period, use genetic engineering other techniques improve optimize brought possibility mass RES. More importantly, be stabilized or protected encapsulation, combined with natural compounds, structurally modified synthesized chemo‐enzymatic great significance food, medicine, clinical applications.
Language: Английский
Citations
1
Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(25), P. 7269 - 7287
Published: March 2, 2022
Stilbenes are phenolic compounds naturally synthesized as secondary metabolites by the shikimate pathway in plants. Research on them has increased recent years due to their therapeutic potential antioxidant, antimicrobial, anti-inflammatory, anticancer, cardioprotective and anti-obesity agents. Amongst them, resveratrol attracted most attention, although there other natural stilbenes with enhanced properties. However, have some physicochemical pharmacokinetic problems that need be overcome before considering applications. Human clinical evidence of bioactivity is still controversial this fact hence, exhaustive basis science needed applied science. This review gathers main biological properties stilbenes, establishes structure-activity relationships among emphasizing current limit applications presenting promising approaches these issues: encapsulation different agents structural modification obtain novel better features. The should move from evident.
Language: Английский
Citations
34
South African Journal of Botany, Journal Year: 2021, Volume and Issue: 139, P. 338 - 351
Published: March 26, 2021
• Orchidaceae is commercially important in pharmaceutical industry apart from cut-flower market. This review addresses biosynthetic pathways and applications of secondary metabolites orchids. Highlights the key vitro strategies for orchid propagation production. Provides novel ideas to harness commercial-scale production has been considered as second largest family among angiosperms. It many its members also possess medicinal properties cure innumerable ailments. Among them, Anoectochilus Dendrobium are prime genera medicinally A greater number such species being used major sources main-stream products. In nature, population orchids at risk, mainly due deforestation. propagation, conventional methods suffer several shortcomings slow growth, poor germination, susceptibility pests, nutritional deficiencies. Therefore, interventions biotechnological tools techniques become quite crucial improvements process simultaneously, metabolites. this context, knowledge different becomes imperative order enhance their via approaches. availability orchids, pathways, pharmacological it further entwined with success that have applied conservation Eventually, biotechnology-based will provide a promising platform construct innovative commercial pharmaceutically available
Language: Английский
Citations
41