Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(9), P. 3051 - 3076
Published: Jan. 1, 2023
This review offers systematic considerations of material design principles and fabrication techniques for biomimetic skin tissue engineering scaffolds.
Language: Английский
Nanomaterials, Journal Year: 2022, Volume and Issue: 12(4), P. 618 - 618
Published: Feb. 12, 2022
Poor wound healing affects millions of people globally, resulting in increased mortality rates and associated expenses. The three major complications with wounds are: (i) the lack an appropriate environment to enable cell migration, proliferation, angiogenesis; (ii) microbial infection; (iii) unstable protracted inflammation. Unfortunately, existing therapeutic methods have not solved these primary problems completely, and, thus, they inadequate medical accomplishment. Over years, integration remarkable properties nanomaterials into has produced significant results. Nanomaterials can stimulate numerous cellular molecular processes that aid microenvironment via antimicrobial, anti-inflammatory, angiogenic effects, possibly changing milieu from nonhealing healing. present article highlights mechanism pathophysiology Further, it discusses current findings concerning prospects challenges nanomaterial usage management chronic wounds.
Language: Английский
Citations
119
Biomaterials Science, Journal Year: 2021, Volume and Issue: 9(12), P. 4388 - 4409
Published: Jan. 1, 2021
Chronic wound has developed into one of the most serious health problems worldwide; rate-limiting stage chronic healing is inflammation stage; we reviewed advances and impact various anti-inflammatory biomaterial platforms.
Language: Английский
Citations
114
ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(5), P. 2069 - 2106
Published: April 22, 2022
Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue culminates with remodeling. These steps significantly overlap each other are aided by various factors such as cells, cytokines (both anti- pro-inflammatory), growth that aid in the formation. In all these advanced biomaterials provide several functional advantages, removing exudates, providing cover, transporting oxygen to site, preventing infection from microbes. addition, serve vehicles carry proteins/drug molecules/growth and/or antimicrobial agents target site. this review, we report recent advancements biomaterials-based regenerative strategies augment skin process. conjunction medical sciences, designing nanoengineered is gaining significant attention for numerous functionalities trigger repair. regard, highlight advent of nanomaterial-based constructs healing, especially those being evaluated clinical settings. Herein, also emphasize competence versatility three-dimensional (3D) bioprinting technique management. Finally, discuss challenges perspective biomaterial-based dressings, along prospective future directions. With utilize a cocktail cell sources, agents, drugs, factors, it expected patient-specific will be developed near future, resulting complete no scar
Language: Английский
Citations
110
Materials Today Chemistry, Journal Year: 2022, Volume and Issue: 27, P. 101319 - 101319
Published: Dec. 21, 2022
Language: Английский
Citations
106
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(26)
Published: March 25, 2023
Abstract When skin trauma occurs, rapid achievement of the post‐wound closure is required to prevent microbial invasion, inhibit scar formation and promote wound healing. To develop a dressing for accelerating post‐wound‐closure healing, thermo‐responsive tissue‐adhesive hydrogel with interpenetrating polymer networks (IPN) fabricated based on N ‐dimethylbisacrylamide (NIPAM) glutaraldehyde (GTA) cross‐linked hyaluronic acid (HA). Results not only confirm thermo‐stimulated self‐contraction tissue adhesiveness HA‐based IPN (PNI‐HA), which effectively aids via mechanical stretch, but also verify hemocompatibility cytocompatibility PNI‐HA that tend accelerate In vivo, mouse model total defect demonstrates acting as sealant significantly achieves sutureless at early stage then promotes healing by reducing inflammatory cells infiltration, promoting angiogenesis well collagen deposition. These results indicate developed offers candidate serve
Language: Английский
Citations
104
Biomaterials Science, Journal Year: 2022, Volume and Issue: 10(15), P. 4058 - 4076
Published: Jan. 1, 2022
Multifunctional wound dressings or smart with pro-angiogenic function, antibacterial properties, anti-inflammatory/antioxidant activity and tissue adhesion for chronic repair.
Language: Английский
Citations
93
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 193, P. 114670 - 114670
Published: Dec. 17, 2022
Language: Английский
Citations
91
Nanoscale Advances, Journal Year: 2022, Volume and Issue: 5(4), P. 992 - 1010
Published: Nov. 9, 2022
The current COVID-19 pandemic, with its numerous variants including Omicron which is 50-70% more transmissible than the previously dominant Delta variant, demands a fast, robust, cheap, and easily deployed identification strategy to reduce chain of transmission, for biosensors have been shown as feasible solution at laboratory scale. use nanomaterials has significantly enhanced performance biosensors, addition CNTs increased detection capabilities an unrivaled level. Among various CNT-based systems, field-effect transistors possess ultra-sensitivity low-noise capacity, allowing immediate analyte determination even in presence limited concentrations, would be typical early infection stages. Recently, CNT transistor-type successfully used fast diagnosis COVID-19, research commercial interest exploiting developments transistors. Recent progress design deployment viral monitoring are covered this paper, remaining obstacles prospects. This work also highlights enormous potential synergistic effects combination other detection.
Language: Английский
Citations
89
Molecules, Journal Year: 2023, Volume and Issue: 28(12), P. 4839 - 4839
Published: June 18, 2023
Human skin pigmentation and melanin synthesis are incredibly variable, impacted by genetics, UV exposure, some drugs. Patients' physical appearance, psychological health, social functioning all a sizable number of conditions that cause pigmentary abnormalities. Hyperpigmentation, where pigment appears to overflow, hypopigmentation, is reduced, the two major classifications pigmentation. Albinism, melasma, vitiligo, Addison's disease, post-inflammatory hyperpigmentation, which can be brought on eczema, acne vulgaris, drug interactions, most common disorders in clinical practice. Anti-inflammatory medications, antioxidants, medications inhibit tyrosinase, prevents production melanin, possible treatments for problems. Skin treated orally topically with herbal remedies, cosmetic products, but doctor should always consulted before beginning any new medicine or treatment plan. This review article explores numerous types problems, their causes, treatments, as well 25 plants, 4 marine species, 17 topical oral now market have been clinically tested treat diseases.
Language: Английский
Citations
87
ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5588 - 5599
Published: Feb. 6, 2023
Monitoring sweat rate is vital for estimating loss and accurately measuring biomarkers of interest. Although various optical or electrical sensors have been developed to monitor the sensible rate, quantification insensible that directly related body thermoregulation skin barrier functions still remains a challenge. This work introduces superhydrophobic sensor based on polyacrylate sodium/MXene composite sandwiched between two textile layers continuously measure vapor from with high sensitivity rapid response. The holey thin substrate reduced stiffness excellent breathability allows permeation vapor, while preventing being affected by external water droplets internal sweat. Integrating flexible wireless communication powering module further yields standalone sensing system rates at different locations diverse application scenarios. Proof-of-concept demonstrations human subjects showcase feasibility evaluate body's assessment thermal comfort, disease conditions, nervous activity. results presented in this also provide low-cost device platform detect other health-relevant (vapor) as next-generation smart healthcare personalized medicine.
Language: Английский
Citations
83