Design of therapeutic biomaterials to control inflammation

Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(7), P. 557 - 574

Published: Feb. 28, 2022

Language: Английский

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Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy

Particle and Fibre Toxicology, Journal Year: 2020, Volume and Issue: 17(1)

Published: Oct. 24, 2020

Abstract Background Plastic is everywhere. It used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable items. Microplastic nanoplastic particulates are formed from bulk fragmentation disintegration of plastic pollution. have recently been detected indoor air remote atmospheric fallout. Due to their small size, microplastic particulate the atmosphere can be inhaled may pose a risk for human health, specifically susceptible populations. When inhaled, nanosized particles shown translocate across pulmonary cell barriers secondary organs, including placenta. However, potential maternal-to-fetal translocation nanosized-plastic impact deposition or accumulation on fetal health remain unknown. In this study we investigated whether nanopolystyrene cross placental barrier deposit tissues after maternal exposure. Results Pregnant Sprague Dawley rats were exposed 20 nm rhodamine-labeled beads (2.64 × 10 14 particles) via intratracheal instillation gestational day (GD) 19. Twenty-four hours later GD 20, evaluated using fluorescent optical imaging. Fetal fixed particle visualization with hyperspectral microscopy. Using isolated perfusion, known concentration was injected into uterine artery. Maternal effluents collected 180 min assessed polystyrene concentration. exposure, weights significantly lower (7 8%, respectively) compared controls. Nanopolystyrene lung, heart, spleen. Polystyrene nanoparticles also observed placenta, liver, lungs, kidney, brain suggesting lung-to-fetal tissue nanoparticle late stage pregnancy. Conclusion These studies confirm that exposure results renders fetoplacental unit vulnerable adverse effects. data vital understanding toxicology developmental origins disease.

Language: Английский

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Nanomedicine in cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Aug. 7, 2023

Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise to multiple undesired side effects. Recent advances nanotechnology, accompanied by our growing understanding of biology and nano-bio interactions, have led development series nanocarriers, which aim improve efficacy while reducing off-target toxicity encapsulated anticancer agents through tumor tissue-, cell-, organelle-specific targeting. However, vast majority nanocarriers do not possess hierarchical targeting capability, their indices often compromised poor accumulation, inefficient cellular internalization, inaccurate subcellular localization. This Review outlines current prospective strategies design organelle-targeted nanomedicines, highlights latest progress technologies can dynamically integrate these three different stages static maximize outcomes. Finally, we briefly discuss challenges future opportunities for clinical translation nanomedicines.

Language: Английский

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Recent trends in protein and peptide-based biomaterials for advanced drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 156, P. 133 - 187

Published: Jan. 1, 2020

Language: Английский

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Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101073 - 101073

Published: Jan. 10, 2021

Language: Английский

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Nanoarchitectonics beyond Self‐Assembly: Challenges to Create Bio‐Like Hierarchic Organization

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(36), P. 15424 - 15446

Published: March 14, 2020

Abstract Incorporation of non‐equilibrium actions in the sequence self‐assembly processes would be an effective means to establish bio‐like high functionality hierarchical assemblies. As a novel methodology beyond self‐assembly, nanoarchitectonics, which has as its aim fabrication functional materials systems from nanoscopic units through methodological fusion nanotechnology with other scientific disciplines including organic synthesis, supramolecular chemistry, microfabrication, and bio‐process, been applied this strategy. The application factors conventional is discussed on basis examples directed assembly, Langmuir–Blodgett layer‐by‐layer assembly. In particular, structures using bio‐active components such proteins or by combination bio‐components two‐dimensional nanomaterials, are described. Methodologies described review article highlight possible approaches nanoarchitectonics concept for creation higher functionalities structural organization.

Language: Английский

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Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20825 - 20849

Published: Nov. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Language: Английский

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Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

Advanced Science, Journal Year: 2021, Volume and Issue: 9(5)

Published: Dec. 19, 2021

Cancer immunotherapy has achieved promising clinical progress over the recent years for its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low patient response rates dose-limiting toxicity remain as major dilemmas immunotherapy. Stimuli-responsive nanoparticles (srNPs) combined with offer possibility amplify anti-tumor immune responses, where weak acidity, high concentration of glutathione, overexpressions enzymes, reactive oxygen species, external stimuli in act triggers controlled drug release. This review highlights design srNPs based on tumor microenvironment and/or combine different drugs, especially immunoregulatory agents, which eventually realize synergistic malignant primary or acquire a long-term memory prevent recurrence. The authors hope that this can provide theoretical guidance construction transformation smart delivery cancer

Language: Английский

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Inorganic nano-carriers based smart drug delivery systems for tumor therapy

Smart Materials in Medicine, Journal Year: 2020, Volume and Issue: 1, P. 32 - 47

Published: Jan. 1, 2020

Tumor is a severe disease that affects human health. In addition to surgical treatment and radiotherapy, applying therapeutic agents can kill the tumor directly or regulate immune systems one of most common treatments. The current problems these are lacking selective targeting causing unfavorable side effects. order solve develop more effective medicines, nano-carriers employed fabricate smart drug delivery systems. recent years, novel inorganic nano-materials, like mesoporous silica nanoparticles, gold graphene oxide black phosphorus, have shown talent in loading capacity, stability, biocompatibility, which becoming candidates for nano-carriers. This review not only provides comprehensive summary on mechanisms nano-carrier based but also summarizes their synthesis, applications, challenges future possibilities.

Language: Английский

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Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(21), P. 9184 - 9205

Published: May 10, 2022

An inconvenient hurdle in the practice of nanomedicine is protein corona, a spontaneous collection biomolecular species by nanoparticles living systems. The corona dynamic composition and may entail improved water suspendability compromised delivery targeting to nanoparticles. How much this nonspecific ensemble determined chemistry nanoparticle core its surface functionalization, how entity dictated biological environments that vary spatiotemporally vivo? do we "live with" exploit without significantly sacrificing efficacy nanomedicines diagnosing curing human diseases? This article discusses chemical biophysical signatures ponders challenges ahead for field nanomedicine.

Language: Английский

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