Revealing the Mutually Enhanced Mechanism of Necroptosis and Immunotherapy Induced by Defect Engineering and Piezoelectric Effect DOI Open Access

Yaqian Du,

Jiani Yang,

Fei He

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Oct. 12, 2023

Abstract Owing to low immunogenicity‐induced immune escape and short‐term circulating responses, the efficiency of immunotherapy is unsatisfactory. Therefore, triggering immunogenic cell death establishing a long‐term, mutually reinforced treatment modality are urgent challenges. In this study, ultrathin CaBi 2 Nb O 9 nanosheets with tunable oxygen vacancies (abbreviated as CBNO‐OV1) prepared for synergistic necroptosis immunotherapy. The optimized vacancy concentration significantly improves piezoelectric effect under ultrasound irradiation, thereby considerably improving generation reactive species (ROS). Density functional theory shows that can improve electron hole separation by suppressing their recombination, thus resulting in enhanced piezocatalytic activity. Moreover, permeability tumor membranes, Ca 2+ influx. Additionally, CBNO‐OV1 also releases portion , which induces assisted explosive ROS. Ribonucleic acid transcription tests suggest mechanisms associated response activation necroptosis. More importantly, trigger significant vivo, activating macrophage M1 polarization through NF‐kappa B pathway promoting T‐cell differentiation.Tumor Necrosis Factor‐α differentiated from macrophages conversely promotes necroptosis, realizing effect. This study demonstrates feasibility amplifying efficacy.

Language: Английский

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies DOI Creative Commons
Hailong Tian, Tingting Zhang, Siyuan Qin

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Language: Английский

Citations

246
Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy DOI
Jin Zhang, Yandai Lin, Zhe Lin

et al.

Advanced Science, Journal Year: 2021, Volume and Issue: 9(5)

Published: Dec. 19, 2021

Cancer immunotherapy has achieved promising clinical progress over the recent years for its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low patient response rates dose-limiting toxicity remain as major dilemmas immunotherapy. Stimuli-responsive nanoparticles (srNPs) combined with offer possibility amplify anti-tumor immune responses, where weak acidity, high concentration of glutathione, overexpressions enzymes, reactive oxygen species, external stimuli in act triggers controlled drug release. This review highlights design srNPs based on tumor microenvironment and/or combine different drugs, especially immunoregulatory agents, which eventually realize synergistic malignant primary or acquire a long-term memory prevent recurrence. The authors hope that this can provide theoretical guidance construction transformation smart delivery cancer

Language: Английский

Citations

195
A Noble AuPtAg‐GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy‐Augmented Mild Photothermal Therapy DOI Creative Commons
Man Wang, Mengyu Chang, Pan Zheng

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(31)

Published: Sept. 25, 2022

Abstract Notwithstanding immune checkpoint blocking (ICB) therapy has made eminent clinical breakthroughs, overcoming immunologically “cold” tumors remains challenging. Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic tumor microenvironment. Further, to amplify thermal sensitivity of cells, glucose oxidase (GOx) introduced suppress production heat shock proteins, thereby promoting therapy. Complementarily, AuPtAg nanozymes with catalase‐like activity can ameliorate hypoxia, significantly improving GOx activity. As result, combination self‐augmented ability PD‐L1 antibody further escalate antitumor efficacy. The AuPtAg‐GOx‐based synergistic starvation therapy, PTT, immunotherapy enhancement strategy be favorable tool effectively kill cancer cells.

Language: Английский

Citations

112
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy DOI Creative Commons
Zili Zhang, Haifeng Zhou, Xiaohu Ouyang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 23, 2022

Since the discovery of Stimulator Interferon Genes (STING) as an important pivot for cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been endeavored to clarify molecular mechanism its activation, physiological function a ubiquitously expressed protein, explore potential therapeutic target in wide range immune-related diseases. With orthodox ligand 2'3'-cyclic GMP-AMP (2'3'-cGAMP) upstream sensor 2'3'-cGAMP synthase (cGAS) be found, STING acquires central functionality best-studied signaling cascade, namely cGAS-STING-IFN pathway. However, recently updated research through structural research, genetic screening, biochemical assay greatly extends current knowledge biology. A second pocket was discovered transmembrane domain synthetic agonist. On downstream outputs, accumulating studies sketch primordial multifaceted roles beyond cytokine-inducing function, such autophagy, cell death, metabolic modulation, endoplasmic reticulum (ER) stress, RNA virus restriction. Furthermore, with expansion interactome, details trafficking also get clearer. After retrospecting brief history viral interference milestone events since STING, we present vivid panorama biology taking into account information, especially versatile outputs functions IFN induction. We summarize pathogenesis various diseases highlight development small-molecular compounds targeting disease treatment combination latest research. Finally, discuss open questions imperative answer.

Language: Английский

Citations

93
Biomimetic and bioinspired nano‐platforms for cancer vaccine development DOI Creative Commons

Chenchao Feng,

Peng Tan, Guangjun Nie

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(3)

Published: April 25, 2023

The advent of immunotherapy has revolutionized the treating modalities cancer. Cancer vaccine, aiming to harness host immune system induce a tumor-specific killing effect, holds great promises for its broad patient coverage, high safety, and combination potentials. Despite promising, clinical translation cancer vaccines faces obstacles including lack potency, limited options tumor antigens adjuvants, immunosuppressive microenvironment. Biomimetic bioinspired nanotechnology provides new impetus designing concepts vaccines. Through mimicking stealth coating, pathogen recognition pattern, tissue tropism pathogen, other irreplaceable properties from nature, biomimetic could gain functions such as longstanding, targeting, self-adjuvanting, on-demand cargo release. specific behavior endogenous molecules each type living entity (cell or microorganism) offer unique features address needs immunotherapy. In this review, strategies inspired by eukaryotic cells, bacteria, viruses will be overviewed advancing vaccine development. Our insights into future development shared at end expediting translation.

Language: Английский

Citations

79
Biologics, theranostics, and personalized medicine in drug delivery systems DOI Creative Commons
Matteo Puccetti, Marilena Pariano, Aurélie Schoubben

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 201, P. 107086 - 107086

Published: Jan. 29, 2024

The progress in human disease treatment can be greatly advanced through the implementation of nanomedicine. This approach involves targeted and cell-specific therapy, controlled drug release, personalized dosage forms, wearable delivery, companion diagnostics. By integrating cutting-edge technologies with delivery systems, greater precision achieved at tissue cellular levels use stimuli-responsive nanoparticles, development electrochemical sensor systems. targeting – by virtue nanotechnology allows for therapy to directed specifically affected tissues while reducing side effects on healthy tissues. As such, nanomedicine has potential transform conditions such as cancer, genetic diseases, chronic illnesses facilitating precise delivery. Additionally, forms devices offer ability tailor unique needs each patient, thereby increasing therapeutic effectiveness compliance. Companion diagnostics further enable efficient monitoring response, enabling customized adjustments plan. question whether all approaches outlined here are viable alternatives current treatments is also discussed. In general, application field biomedicine may provide a strong alternative existing several reasons. this review, we aim present evidence that, although early stages, fully merging technology innovative shows promise successful across various areas, including cancer or diseases.

Language: Английский

Citations

67
Dual‐Cascade Activatable Nanopotentiators Reshaping Adenosine Metabolism for Sono‐Chemodynamic‐Immunotherapy of Deep Tumors DOI Creative Commons
Meixiao Zhan,

Fengshuo Wang,

Yao Liu

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(10)

Published: Feb. 2, 2023

Immunotherapy is an attractive treatment strategy for cancer, while its efficiency and safety need to be improved. A dual-cascade activatable nanopotentiator sonodynamic therapy (SDT) chemodynamic (CDT)-cooperated immunotherapy of deep tumors via reshaping adenosine metabolism herein reported. This (NPMCA) constructed through crosslinking deaminase (ADA) with chlorin e6 (Ce6)-conjugated manganese dioxide (MnO2) nanoparticles a reactive oxygen species (ROS)-cleavable linker. In the tumor microenvironment ultrasound (US) irradiation, NPMCA mediates CDT SDT concurrently in covered 2-cm tissues produce abundant ROS, which results scissoring ROS-cleavable linkers activate ADA within NCMCA block metabolism. Moreover, immunogenic cell death (ICD) dying cells upregulation stimulator interferon genes (STING) triggered by generated ROS Mn2+ from NPMCA, respectively, leading activation antitumor immune response. The potency response further reinforced reducing accumulation activated ADA. As result, enables SDT-cooperated immunotherapy, showing obviously improved therapeutic efficacy inhibit growths bilateral tumors, primary are tissues.

Language: Английский

Citations

66
Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering DOI Creative Commons
Kai Chen, Yonghui Li, Youbin Li

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 24, 2023

Abstract The stimuli-responsive nanofibers prepared by electrospinning have become an ideal material due to their large specific surface area and porosity, which can respond extremely quickly external environmental incitement. As intelligent drug delivery platform, efficiently load drugs then be stimulated conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) achieve slow, on-demand targeted release, showing great potential in areas such as delivery, tumor therapy, wound dressing, tissue engineering. Therefore, this paper reviews the recent trends of electrospun platforms field biomedicine.

Language: Английский

Citations

61
Three-dimensional macroscopic absorbents: From synergistic effects to advanced multifunctionalities DOI
Shijie Zhang, Di Lan, Xingliang Chen

et al.

Nano Research, Journal Year: 2023, Volume and Issue: 17(3), P. 1952 - 1983

Published: Oct. 14, 2023

Language: Английский

Citations

53
A Vacancy‐Engineering Ferroelectric Nanomedicine for Cuproptosis/Apoptosis Co‐Activated Immunotherapy DOI

Yaqian Du,

Xudong Zhao, Fei He

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 4, 2024

Abstract Low efficacy of immunotherapy due to the poor immunogenicity most tumors and their insufficient infiltration by immune cells highlights importance inducing immunogenic cell death activating system for achieving better treatment outcomes. Herein, ferroelectric Bi 2 CuO 4 nanoparticles with rich copper vacancies (named BCO‐V Cu ) are rationally designed engineered ferroelectricity‐enhanced apoptosis, cuproptosis, subsequently evoked immunotherapy. In this structure, suppressed recombination electron–hole pairs band bending polarization lead high catalytic activity, triggering reactive oxygen species bursts apoptosis. The fragments produced apoptosis serve as antigens activate T cells. Moreover, generated charge catalysis, nanomedicine can act “a smart switch” open membrane, promote nanomaterial endocytosis, shut down + outflow pathway evoke thus a strong response is triggered reduced content adenosine triphosphate. Ribonucleic acid transcription tests reveal pathways related activation. Thus, study firstly demonstrates feasible strategy enhancing using single semiconductor‐induced cuproptosis.

Language: Английский

Citations

38