Transfer Hydrogenation from 2-propanol to Acetophenone Catalyzed by [RuCl2(η6-arene)P] (P = monophosphine) and [Rh(PP)2]X (PP = diphosphine, X = Cl−, BF4−) Complexes

Catalysts, Journal Year: 2020, Volume and Issue: 10(2), P. 162 - 162

Published: Feb. 1, 2020

The reduction of ketones through homogeneous transfer hydrogenation catalyzed by transition metals is one the most important routes for obtaining alcohols from carbonyl compounds. interest this method increases when opportune catalytic precursors are able to perform transformation in an asymmetric fashion, generating enantiomerically enriched chiral alcohols. This reaction has been extensively studied terms catalysts and variety substrates. A large amount information about possible mechanisms available nowadays, which high importance development systems with excellent outcomes conversion, enantioselectivity Turn Over Frequency. On other side, many mechanistic aspects still unclear, especially those have shown only moderate performances hydeogenation. case neutral [RuCl2(η6-arene)(P)] cationic [Rh(PP)2]X (X = anion; P PP mono- bidentate phosphine, respectively) complexes. Herein, a summary known Transfer Hydrogenation these complexes provided continuous focus on more relevant features.

Language: Английский

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Preparation of monocarbonyl ruthenium complexes bearing bidentate nitrogen and phosphine ligands and their catalytic activity in carbonyl compound reduction

Dalton Transactions, Journal Year: 2019, Volume and Issue: 48(33), P. 12560 - 12576

Published: Jan. 1, 2019

A series of novel monocarbonyl ruthenium catalysts containing bidentate dinitrogen or/and diphosphine ligands are easily obtained through a general and straightforward approach.

Language: Английский

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Abnormal NHC ruthenium catalysts: mechanistic investigations of their preparation and steric influence on catalytic performance

Catalysis Science & Technology, Journal Year: 2022, Volume and Issue: 12(18), P. 5597 - 5603

Published: Jan. 1, 2022

Preparation of bis-aNHC Ru catalysts, identification formation intermediates and application in transfer hydrogenation Oppenauer-type oxidation, observing an inversion activity appearing to be dependent on steric hindrance.

Language: Английский

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Acetate Acetylacetonate Ampy Ruthenium(II) Complexes as Efficient Catalysts for Ketone Transfer Hydrogenation

ChemCatChem, Journal Year: 2020, Volume and Issue: 12(13), P. 3537 - 3544

Published: April 18, 2020

Abstract The mixed acetate acetylacetonate (acac) ruthenium(II) phosphine complexes Ru(OAc)(acac)P 2 [P =(PPh 3 ) , Ph P(CH 4 PPh (dppb)] were prepared by protonation of Ru(OAc) (PPh with acetylacetone in dichloromethane. Reaction the dppb derivative 2‐(aminomethyl)pyridine (ampy) affords complex Ru(OAc)(acac)(ampy)(dppb), which converts to [Ru(acac)(ampy)(dppb)](OAc) toluene at 90 °C. In former ampy ligand is monodentate and coordinates through NH ‐moiety. isolated acac are active catalysts for transfer hydrogenation ketones loadings as low 0.01 mol%, having a strong accelerating effect. Several aromatic aliphatic ketone substrates converted their corresponding alcohols, different electronic influences substituents on acetophenone tolerated.

Language: Английский

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Cationic carboxylate and thioacetate ruthenium(ii) complexes: synthesis and cytotoxic activity against anaplastic thyroid cancer cells

Dalton Transactions, Journal Year: 2020, Volume and Issue: 49(24), P. 8375 - 8388

Published: Jan. 1, 2020

High cytotoxic and antimetastatic activities against anaplastic thyroid cancer are displayed by cationic complexes [RuX(CO)(dppb)(phen)]Y (X = Y OAc, OPiv, SAc, NCS; X Cl PF₆).

Language: Английский

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Preparation of Neutral trans - cis [Ru(O₂CR)₂P₂(NN)], Cationic [Ru(O₂CR)P₂(NN)](O₂CR) and Pincer [Ru(O₂CR)(CNN)P₂] (P = PPh₃, P₂ = diphosphine) Carboxylate Complexes and their Application in the Catalytic Carbonyl Compounds Reduction

Organometallics, Journal Year: 2021, Volume and Issue: 40(8), P. 1086 - 1103

Published: April 14, 2021

The diacetate complexes trans-[Ru(κ1-OAc)2(PPh3)2(NN)] (NN = ethylenediamine (en) (1), 2-(aminomethyl)pyridine (ampy) (2), 2-(aminomethyl)pyrimidine (ampyrim) (3)) have been isolated in 76–88% yield by reaction of [Ru(κ2-OAc)2(PPh3)2] with the corresponding nitrogen ligands. ampy-type derivatives 2 and 3 undergo isomerization to thermodynamically most stable cationic [Ru(κ1-OAc)(PPh3)2(NN)]OAc (2a 3a) cis-[Ru(κ1-OAc)2(PPh3)2(NN)] (2b 3b) methanol at RT. trans-[Ru(κ1-OAc)2(P2)2] (P2 dppm (4), dppe (5)) compounds synthesized from suitable diphosphine toluene 95 °C. complex cis-[Ru(κ1-OAc)2(dppm)(ampy)](6) has obtained reflux ampy. trans-[Ru(κ1-OAc)2P2(NN)] (7–16; NN en, ampy, ampyrim, 8-aminoquinoline; P2 dppp, dppb, dppf, (R)-BINAP) can be easily a treatment ligands Alternatively these prepared trans-[Ru(OAc)2(PPh3)2(NN)] MEK 50 use (R)-BINAP affords trans-[Ru(κ1-OAc)2((R)-BINAP)(NN)] ampy (11), ampyrim (15)) as single stereoisomers. Treatment 8–15 RT leads [Ru(κ2-OAc)P2(NN)]OAc (8a–15a; ampyrim; (R)-BINAP). Similarly 2, dipivalate trans-[Ru(κ1-OPiv)2(PPh3)2(ampy)] (18) is [Ru(κ2-OPiv)2(PPh3)2] (17) CHCl3. pincer acetate [Ru(κ1-OAc)(CNNOMe)(PPh3)2] (19) HCNNOMe ligand 2-propanol NEt3 reflux. In addition, dppb [Ru(κ1-OAc)(CNN)(dppb)] (CNN AMTP (20), AMBQPh (21)) [Ru(κ2-OAc)2(PPh3)2], HAMTP or HAMBQPh NEt3, respectively. are active transfer hydrogenation H2 carbonyl S/C values up 10000 TOF 160000 h–1.

Language: Английский

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Bulky Diphosphine Acetate Ruthenium Complexes: Synthesis and Catalytic Activity in Ketone Transfer Hydrogenation and Alkyne Dimerization

Organometallics, Journal Year: 2020, Volume and Issue: 39(17), P. 3180 - 3193

Published: Aug. 18, 2020

Several mononuclear ruthenium complexes containing bulky diphosphines have been easily prepared from acetate precursors. The cyclohexyl complex [Ru(η2-OAc)2(DCyPF)] (1-cy; DCyPF = 1,1′-bis(dicyclohexylphosphino)ferrocene) is synthesized [Ru(η2-OAc)2(PPh3)2] and in toluene at reflux, whereas the ethylenediamine (en) derivatives trans-[Ru(η1-OAc)2(PP)(en)] (PP 1,1′-bis(diisopropylphosphino)ferrocene (DiPPF) (2), (3)) obtained a one-pot reaction [Ru(η2-OAc)2(PPh3)2], PP, en n-heptane. Treatment of isopropylphosphine [Ru(η2-OAc)2(DiPPF)] (1-ip) with 2-(aminomethyl)pyridine (ampy) methanol affords isolation mixture cationic [Ru(η2-OAc)(DiPPF)(ampy)]OAc (5a) cis-[Ru(η1-OAc)2(DiPPF)(ampy)] (5b) (4/1 molar ratio), via trans-[Ru(η1-OAc)2(DiPPF)(ampy)] (4) characterized low temperature. analogous compound trans-[Ru(η1-OAc)2(DCyPF)(ampy)] (6), ampy heptane, slowly converts into [Ru(η2-OAc)(DCyPF)(ampy)]OAc (7) RT. monocarbonyl [Ru(η1-OAc)(η2-OAc)(PP)(CO)] 1,3-bis(cyclohexylphosphino)propane (DCyPP) (8), (R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldicyclohexylphosphine (Josiphoscy) (9)) are [Ru(η1-OAc)(η2-OAc)(PPh3)2(CO)] suitable diphosphine. [Ru(η1-OAc)(η2-OAc)(DiPPF)(CO)] (10) phenylacetylene presence pyridine leads to alkynyl [Ru(η2-OAc)(C≡CPh)(DiPPF)(CO)] (11), by X-ray diffraction analysis. Protonation 10 2 equiv TFA RT gives [Ru(η1-OCOCF3)(η2-OCOCF3)(DiPPF)(CO)] (12). dicarbonyl trans,cis-[Ru(η1-OAc)2(DiPPF)(CO)2] (13) 1-ip CO (1 atm) CH2Cl2, isomer cis,cis-[Ru(η1-OAc)2(DiPPF)(CO)2] (14) can be carbonylation 10. When 13 heated solid state, formed decarbonylation. These promote transfer hydrogenation acetophenone 2-propanol (S/C 1000–2000) NaOiPr (2 mol %), affording TOF value up 81000 h–1 for 9 30 °C. Complex catalyzes head-to-head dimerization terminal alkynes 1,4-enynes reflux high stereoselectivity kinetic Z isomer.

Language: Английский

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Towards mid-valent rhenium fluoro-phosphine complexes via hexafluoridorhenate(IV) anion pathway assisted by trifluoro acetic acid

Inorganic Chemistry Communications, Journal Year: 2020, Volume and Issue: 119, P. 108064 - 108064

Published: June 29, 2020

Language: Английский

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Efficient, Facile, and Green Synthesis of Ruthenium Carboxylate Complexes by Manual Grinding

Processes, Journal Year: 2024, Volume and Issue: 12(7), P. 1413 - 1413

Published: July 6, 2024

Recently, scientists have been developing sustainable processes, and in this context, mechanochemistry is commonly associated with green chemistry for its ability to reduce waste generation from chemical reactions. The well-known acetate complex, diacetate bis(triphenylphosphine) ruthenium(II) [Ru(OAc)2(PPh3)2], a versatile precursor preparing active complexes several catalytic This report presents an efficient straightforward manual grinding protocol the synthesis of ruthenium carboxylate starting commercially available [RuCl2(PPh3)3] metal carboxylates. work represents novel preliminary investigation into precursors’ alternative solventless route based on grinding. To our knowledge, first time [Ru(OAc)2(PPh3)2] has prepared via mechanochemical procedure. method also investigated other alkali carboxylates yields ranging 30 80% were obtained. A comparison sustainability environmental impact between conventional solution carried out using E-factor Mass Productivity. While complex MP only slightly better compared solvent (3 vs. 4 ~6 5 MP), benzoate higher results found (1 ~4 10 MP).

Language: Английский

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Ruthenium and Osmium Complexes Containing NHC and π-Acid Ligands

Elsevier eBooks, Journal Year: 2022, Volume and Issue: unknown, P. 444 - 527

Published: Jan. 1, 2022

Language: Английский

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