Pharmacological Research,
Journal Year:
2022,
Volume and Issue:
177, P. 106076 - 106076
Published: Jan. 21, 2022
Drug
discovery
from
natural
sources
is
going
through
a
renaissance,
having
spent
many
decades
in
the
shadow
of
synthetic
molecule
drug
discovery,
despite
fact
that
product-derived
compounds
occupy
much
greater
chemical
space
than
those
created
chemistry
methods.
With
this
new
era
comes
possibilities,
not
least
novel
targets
have
emerged
recent
times
and
development
state-of-the-art
technologies
can
be
applied
to
sources.
Although
progress
has
been
made
with
some
immunomodulating
drugs,
there
remains
pressing
need
for
agents
used
treat
wide
variety
conditions
arise
disruption,
or
over-activation,
immune
system;
products
may
therefore
key
filling
gap.
Recognising
that,
at
present,
no
authoritative
article
details
current
immunomodulatory
activity
products,
in-depth
review
arisen
joint
effort
between
International
Union
Basic
Clinical
Pharmacology
(IUPHAR)
Natural
Products
Immunopharmacology
Sections,
contributions
number
world-leading
researchers
field
product
provide
"position
statement"
on
what
offer
search
argents.
To
end,
we
historical
look
previous
discoveries
naturally
occurring
immunomodulators,
present
picture
status
insight
into
future
opportunities
challenges
drugs
immune-related
diseases.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(2), P. 410 - 410
Published: Jan. 15, 2024
Cannabis,
renowned
for
its
historical
medicinal
use,
harbours
various
bioactive
compounds—cannabinoids,
terpenes,
and
flavonoids.
While
major
cannabinoids
like
delta-9-tetrahydrocannabinol
(THC)
cannabidiol
(CBD)
have
received
extensive
scrutiny
their
pharmacological
properties,
emerging
evidence
underscores
the
collaborative
interactions
among
these
constituents,
suggesting
a
collective
therapeutic
potential.
This
comprehensive
review
explores
intricate
relationships
synergies
between
cannabinoids,
flavonoids
in
cannabis.
Cannabinoids,
pivotal
cannabis’s
bioactivity,
exhibit
well-documented
analgesic,
anti-inflammatory,
neuroprotective
effects.
Terpenes,
aromatic
compounds
imbuing
distinct
flavours,
not
only
contribute
to
sensory
profile
but
also
modulate
cannabinoid
effects
through
diverse
molecular
mechanisms.
Flavonoids,
another
cannabis
component,
demonstrate
antioxidant,
particularly
relevant
neuroinflammation.
The
entourage
hypothesis
posits
that
combined
cannabinoid,
terpene,
flavonoid
action
yields
synergistic
or
additive
effects,
surpassing
individual
compound
efficacy.
Recognizing
nuanced
is
crucial
unravelling
complete
Tailoring
treatments
based
on
holistic
composition
of
strains
allows
optimization
outcomes
while
minimizing
potential
side
imperative
delve
into
roles
flavonoids,
offering
promising
prospects
innovative
interventions
advocating
continued
research
unlock
full
within
realm
natural
plant-based
medicine.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(3), P. 1136 - 1136
Published: Feb. 8, 2020
Helicobacter
pylori
is
a
well-known
pathogen
that
highly
prevalent
in
the
world
population,
and
H.
infection
potentially
hazardous
to
humans
because
of
its
relationship
various
gastrointestinal
diseases,
such
as
gastric
ulcers,
chronic
gastritis,
carcinoma.
Therefore,
clinical
guidelines
recommend
taking
antibiotic
therapy
eradicate
pathogen,
which
usually
leads
desired
therapeutic
effect.
However,
some
failure
cases
this
indicate
increasing
resistance
side
effects
may
affect
Here
we
propose
using
probiotics
supplementation
for
provide
an
extra
help.
Recent
studies
have
shown
probiotic
has
promising
application
prospects;
it
can
enhance
effect
achieve
better
result
maintain
balance
host
microbiota.
In
summary,
under
global
conditions
prevalence,
worthy
further
future
application.
Natural Product Reports,
Journal Year:
2020,
Volume and Issue:
37(11), P. 1454 - 1477
Published: Jan. 1, 2020
Natural
products
have
historically
been
a
rich
source
of
diverse
chemical
matter
with
numerous
biological
activities,
and
played
an
important
role
in
drug
discovery
many
areas
including
infectious
disease.
Synthetic
medicinal
chemistry
been,
continue
to
be,
tools
realize
the
potential
natural
as
therapeutics
probes.
The
formation
biofilms
by
bacteria
infection
setting
is
significant
factor
recalcitrance
bacterial
infections,
conferring
increased
tolerance
antibiotics
host
immune
response,
yet
there
are
no
approved
for
combatting
biofilm-based
infections.
Small
molecules
that
interfere
ability
form
maintain
can
overcome
antibiotic
conferred
biofilm
phenotype,
combination
therapies
conventional
antibiotics.
Many
anti-biofilm
activity
identified
from
plants,
microbes,
marine
life,
including:
elligic
acid
glycosides,
hamamelitannin,
carolacton,
skyllamycins,
promysalin,
phenazines,
bromoageliferin,
flustramine
C,
meridianin
D,
brominated
furanones.
Total
synthesis
programs
facilitated
structure
confirmation,
identification
critical
structural
motifs,
better
understanding
mechanistic
pathways,
development
more
potent,
accessible,
or
pharmacologically
favorable
derivatives
products.
Journal of Medicinal Chemistry,
Journal Year:
2020,
Volume and Issue:
63(21), P. 12137 - 12155
Published: Aug. 17, 2020
This
Perspective
of
the
published
essential
medicinal
chemistry
cannabidiol
(CBD)
provides
evidence
that
popularization
CBD-fortified
or
CBD-labeled
health
products
and
CBD-associated
claims
lacks
a
rigorous
scientific
foundation.
CBD's
reputation
as
cure-all
puts
it
in
same
class
other
"natural"
panaceas,
where
valid
ethnobotanicals
are
reduced
to
single,
purportedly
active
ingredients.
Such
reductionist
approaches
oversimplify
useful,
chemically
complex
mixtures
an
attempt
rationalize
commercial
utility
natural
compounds
exploit
label.
Literature
associates
CBD
with
certain
semiubiquitous,
broadly
screened,
primarily
plant-based
substances
undocumented
purity
interfere
bioassays
have
low
likelihood
becoming
therapeutic
agents.
Widespread
challenges
pandemic
crises
such
SARS-CoV-2
create
circumstances
under
which
scientists
must
be
particularly
vigilant
about
healing
lack
solid
foundational
data.
Herein,
we
offer
critical
review
properties
CBD,
well
precise
definitions
CBD-containing
products,
distilled
reveal
factors
impact
its
development
agent.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2020,
Volume and Issue:
8(5), P. 2246 - 2259
Published: Jan. 27, 2020
The
potential
of
natural
deep
eutectic
systems
(NADESs)
to
efficiently
extract
astaxanthin
(AXT)
contained
in
crab
shell
wastes
was
evaluated.
Different
terpene-based
mixtures
were
prepared
and
characterized.
Aiming
at
maximizing
the
AXT
recovery,
we
evaluated
effect
operating
temperature
time
on
extraction
performance.
As
a
proof
concept,
this
paper
also
highlights
NADESs
for
from
shrimp
shells,
mussels,
Haematococcus
pluvialis.
biological
AXT-rich
extracts;
standard;
NADESs,
their
individual
components,
equivalent
physical
evaluated,
including
cytotoxicity,
antiproliferative
effects
human
colorectal
cancer
cells,
antimicrobial
against
Staphylococcus
aureus
Escherichia
coli.
Results
showed
that
extractions
with
menthol:myristic
acid
(8:1)
able
match
yield
obtained
by
Soxhlet
acetone.
Additionally,
when
using
same
recover
other
biomasses
under
study,
there
3-
657-fold
increase
yields
compared
extraction.
extracts
potential.
This
study
suggests
can
truly
be
used
as
alternative
media
recovery
waste
biomass
these
respective
have
ingredients
industrial
applications.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(19), P. 10746 - 10746
Published: Oct. 4, 2021
Bacterial
infections
of
skin
and
wounds
may
seriously
decrease
the
quality
life
even
cause
death
in
some
patients.
One
largest
concerns
their
treatment
is
growing
antimicrobial
resistance
bacterial
infectious
agents
spread
resistant
strains
not
only
hospitals
but
also
community.
This
trend
encourages
researchers
to
seek
for
new
effective
safe
therapeutical
agents.
The
pharmaceutical
industry,
focusing
mainly
on
libraries
synthetic
compounds
as
a
drug
discovery
source,
often
failing
battle
with
bacteria.
In
contrast,
many
natural
compounds,
and/or
whole
complex
plants
extracts,
are
this
field,
inactivating
or
decreasing
virulence.
Natural
products
act
comprehensively;
them
have
antibacterial,
anti-inflammatory
effects
support
tissue
regeneration
wound
healing.
European
legislative
field
medicinal
use
formed
by
Medicines
Agency
(EMA),
based
scientific
work
its
Committee
Herbal
Medicinal
Products
(HMPC).
HMPC
establishes
EU
monographs
covering
therapeutic
uses
conditions
herbal
substances
preparations,
mostly
folk
medicine,
including
data
from
research.
review,
active
constituents
recommended
EMA
disorders
discussed
terms
antibacterial
effect.
source
information
about
these
plant
review
represented
research
articles
listed
databases
(Science
Direct,
PubMed,
Scopus,
Web
Science,
etc.)
published
recent
years.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(16), P. 3367 - 3367
Published: Aug. 17, 2022
Nootropics,
also
known
as
"smart
drugs"
are
a
diverse
group
of
medicinal
substances
whose
action
improves
human
thinking,
learning,
and
memory,
especially
in
cases
where
these
functions
impaired.
This
review
provides
an
up-to-date
overview
the
potential
effectiveness
importance
nootropics.
Based
on
their
nature
effects,
this
heterogeneous
drugs
has
been
divided
into
four
subgroups:
classical
nootropic
compounds,
increasing
brain
metabolism,
cholinergic,
plants
extracts
with
effects.
Each
subgroup
nootropics
contains
several
main
representatives,
for
each
one,
its
uses,
indications,
experimental
treatments,
dosage,
possible
side
effects
contraindications
discussed.
For
plant
extracts,
there
is
brief
description
representative,
occurrence,
history,
chemical
composition
part.
Lastly,
specific
recommendations
regarding
use
by
both
ill
healthy
individuals
summarized.
