Photoredox-catalyzed diastereoselective dearomative prenylation and reverse-prenylation of electron-deficient indole derivatives DOI Creative Commons

Xuexue Chang,

Fangqing Zhang,

Shibo Zhu

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 30, 2023

Abstract Prenylated and reverse-prenylated indolines are privileged scaffolds in numerous naturally occurring indole alkaloids with a broad spectrum of important biological properties. Development straightforward stereoselective methods to enable the synthesis structurally diverse prenylated indoline derivatives is highly desirable challenging. In this context, most direct approaches achieve goal generally rely on transition-metal-catalyzed dearomative allylic alkylation electron-rich indoles. However, electron-deficient indoles much less explored, probably due their diminished nucleophilicity. Herein, photoredox-catalyzed tandem Giese radical addition/Ireland–Claisen rearrangement disclosed. Diastereoselective prenylation reverse-prenylation proceed smoothly under mild conditions. An array tertiary α-silylamines as precursors readily incorporated 2,3-disubstituted high functional compatibility excellent diastereoselectivity (>20:1 d.r.). The corresponding transformations secondary provide biologically lactam-fused one-pot synthesis. Subsequently, plausible photoredox pathway proposed based control experiments. preliminary bioactivity study reveals potential anticancer property these appealing indolines.

Language: Английский

Pseudomonas aeruginosa Biofilms DOI Open Access
Minh Tam Tran Thi, David Wibowo, Bernd H. A. Rehm

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(22), P. 8671 - 8671

Published: Nov. 17, 2020

Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute and chronic infections in individuals with compromised immune systems. Its highly notorious persistence clinical settings attributed to its ability form antibiotic-resistant biofilms. Biofilm architecture built mostly by autogenic extracellular polymeric substances which function as a scaffold encase the bacteria together on surfaces, protect them from environmental stresses, impedes phagocytosis thereby conferring capacity for colonization long-term persistence. Here we review current knowledge P. biofilms, development stages, molecular mechanisms of invasion conferred Explosive cell lysis within bacterial biofilm produce essential communal materials, interspecies biofilms commensal Streptococcus virulence possibly improves disease conditions will also be discussed. Recent research diagnostics investigated. Finally, therapeutic strategies treatment along their advantages limitations compiled.

Language: Английский

Citations

622
Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties DOI
Yangcui Qu, Yi Zou,

Guannan Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(11), P. 13353 - 13383

Published: March 11, 2024

Biofilm contamination presents a significant threat to public health, the food industry, and aquatic/marine-related applications. In recent decades, although various methods have emerged combat biofilm contamination, intricate persistent nature of biofilms makes complete eradication challenging. Therefore, innovative alternative solutions are imperative for addressing formation. Instead solely focusing on mature biofilms, strategically advantageous measures involve delay or prevention formation surfaces. Quorum sensing, communication system enabling bacteria coordinate their behavior based population density, plays pivotal role in numerous microbial species. Materials possessing antibiofilm properties that target quorum sensing gained considerable attention potential prevent This Review consolidates research progress utilization materials with antiquorum combating These can be categorized into three distinct types: (i) nanomaterials, (ii) surfaces, (iii) hydrogels capabilities. Finally, concludes brief discussion current challenges outlines avenues future research.

Language: Английский

Citations

22
An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention DOI Creative Commons

Tsvetozara Damyanova,

Petya D. Dimitrova,

Dayana Borisova

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 162 - 162

Published: Jan. 24, 2024

Biofilm formation is considered one of the primary virulence mechanisms in Gram-positive and Gram-negative pathogenic species, particularly those responsible for chronic infections promoting bacterial survival within host. In recent years, there has been a growing interest discovering new compounds capable inhibiting biofilm formation. This promising antivirulence strategy that could potentially overcome antibiotic resistance issues. Effective antibiofilm agents should possess distinctive properties. They be structurally unique, enable easy entry into cells, influence quorum sensing signaling, synergize with other antibacterial agents. Many these properties are found both natural systems isolated from plants synthetic like nanoparticles nanocomposites. this review, we discuss clinical nature biofilm-associated some associated their tolerance. We focus on advantages efficacy various as therapeutic approach to control biofilms address multidrug bacteria.

Language: Английский

Citations

17
Anti-biofilm activity of marine algae-derived bioactive compounds DOI Creative Commons
Asma Behzadnia, Marzieh Moosavi‐Nasab, Najmeh Oliyaei

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 12, 2024

A large number of microbial species tend to communicate and produce biofilm which causes numerous infections, antibiotic resistance, economic problems across different industries. Therefore, advanced anti-biofilms are required with novel attributes targets, such as quorum sensing communication system. Meanwhile, inhibitors promising anti-biofilm molecules result in the inhibition particular phenotype expression blocking cell-to-cell communication, would be more acceptable than conventional strategies. Many natural products identified agents from plants, microorganisms, marine extracts. Marine algae sources broadly compounds activity. Algae extracts their metabolites sulfated polysaccharides (fucoidan), carotenoids (zeaxanthin lutein), lipid fatty acids (γ-linolenic acid linoleic acid), phlorotannins can inhibit cell attachment, reduce growth, interfere pathway by related enzymes, disrupt extracellular polymeric substances. In this review, mechanisms formation, pathway, recently will discussed.

Language: Английский

Citations

16
Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant Escherichia coli DOI
Hang Sun, Shiyu Huang,

Ponmani Jeyakkumar

et al.

Journal of Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 65(1), P. 436 - 459

Published: Dec. 29, 2021

Natural berberine-derived azolyl ethanols as new structural antibacterial agents were designed and synthesized for fighting with dreadful bacterial resistance. Partial target molecules exhibited potent activity against the tested strains, particularly, nitroimidazole derivative 4d benzothiazole-2-thoil compound 18b, low cytotoxicity both exerted strong activities multidrug-resistant Escherichia coli at concentrations 0.007 0.006 mM, respectively. Meanwhile, active compounds 18b possessed ability to rapidly kill bacteria observably eradicate E. biofilm by reducing exopolysaccharide content prevent adhesion, which was conducive alleviating development of Preliminary mechanistic explorations suggested that excellent potential might be attributed their disintegrate membrane, accelerate ROS accumulation, reduce metabolism, intercalate into DNA groove. These results provided powerful information further exploitation natural berberine derivatives pathogens.

Language: Английский

Citations

77
Helicobacter pylori Biofilm-Related Drug Resistance and New Developments in Its Anti-Biofilm Agents DOI Creative Commons
Chong Hou, Fangxu Yin, Song Wang

et al.

Infection and Drug Resistance, Journal Year: 2022, Volume and Issue: Volume 15, P. 1561 - 1571

Published: April 1, 2022

Abstract: Helicobacter pylori is one of the most common pathogenic bacterium worldwide, infecting about 50% world's population. It a major cause several upper gastrointestinal diseases, including peptic ulcers and gastric cancer. The emergence H. resistance to antibiotics has been clinical challenge in field gastroenterology. In course infection, some bacteria invade epithelium are encapsulated into self-produced matrix form biofilms that protect from external threats. Bacteria with biofilm structures can be up 1000 times more resistant than planktonic bacteria. This implies targeting might an effective strategy alleviate drug resistance. Therefore, it important develop drugs eliminate or disperse biofilms. recent years, anti-biofilm agents have investigated as alternative complementary therapies reduce rate article discusses formation biofilms, relationship between , developments research Keywords: biofilm, formation, molecules, antibiotic resistance, mechanism

Language: Английский

Citations

46
Biofilms as a microbial hazard in the food industry: A scoping review DOI
Manjeet Sharan, Deepthi Vijay, Pankaj Dhaka

et al.

Journal of Applied Microbiology, Journal Year: 2022, Volume and Issue: 133(4), P. 2210 - 2234

Published: Aug. 10, 2022

Biofilms pose a serious public health hazard with significant economic impact on the food industry. The present scoping review is designed to analyse literature published during 2001-2020 biofilm formation of microbes, their detection methods, and association antimicrobial resistance (if any). peer-reviewed articles retrieved from 04 electronic databases were assessed using PRISMA-ScR guidelines. From 978 preliminary search results, total 88 publications included in study. On analysis, commonly isolated pathogens Listeria monocytogenes, Staphylococcus aureus, Salmonella spp., Escherichia coli, Bacillus Vibrio Campylobacter jejuni Clostridium perfringens. biofilm-forming ability microbes was found be influenced by various factors such as attachment surfaces, temperature, presence other species, nutrient availability etc. A 18 studies characterized genes, particularly for S. E. coli. In most studies, polystyrene plate and/or stainless-steel coupons used formation, carried out crystal violet assays counting method. strain-specific differences observed many few analysis multi-species biofilms. between not clearly defined. Further, viable but non-culturable form foodborne posing an unseen (by conventional cultivation techniques) potent threat safety. recommends need carrying systematic surveys risk biofilms chain highlight evidence-based concerns, especially regions where microbiological hazards are quite prevalent.

Language: Английский

Citations

42
Evolving biofilm inhibition and eradication in clinical settings through plant-based antibiofilm agents DOI Creative Commons
Eduarda Silva, J. A. Teixeira, Maria Olívia Pereira

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154973 - 154973

Published: July 17, 2023

After almost 100 years since evidence of biofilm mode growth and decades intensive investigation about their formation, regulatory pathways mechanisms antimicrobial tolerance, nowadays there are still no therapeutic solutions to eradicate bacterial biofilms biomedical related issues.This review intends provide a comprehensive summary the recent most relevant published studies on plant-based products, or isolated compounds with antibiofilm activity action identified molecular targets against biofilms. The objective is offer new perspective data for clinical researchers aiming prevent eliminate biofilm-associated infections caused by pathogens.The search was performed considering original research articles PubMed, Web Science Scopus from 2015 April 2023, using keywords such as "antibiofilm", "antivirulence", "phytochemicals" "plant extracts".Over 180 were considered this focus priority human pathogens listed World Health Organization, including Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae Escherichia coli. Inhibition detachment dismantling formed these found extract/products derivative compounds. Although combination products antibiotics recorded discussed, topic currently poorly explored only reduced number species.This clearly demonstrates that may be promising strategy associated infections. thoroughly reviewing vast amount carried out over years, it concluded mostly able formation through inhibition quorum sensing signals, but also disrupt mature developed multidrug resistant bacteria targeting extracellular polymeric substance. Flavonoids phenolic seemed effective

Language: Английский

Citations

34
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022 DOI
Sunmin Woo, Lewis Marquez, William J. Crandall

et al.

Natural Product Reports, Journal Year: 2023, Volume and Issue: 40(7), P. 1271 - 1290

Published: Jan. 1, 2023

Plants produce a wide array of secondary metabolites capable inhibiting pathways crucial for microbial survival and pathogenicity.

Language: Английский

Citations

27
Liposomes-Based Drug Delivery Systems of Anti-Biofilm Agents to Combat Bacterial Biofilm Formation DOI Creative Commons

Zinb Makhlouf,

Amaal Abdulraqeb Ali, Mohammad H. Al‐Sayah

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(5), P. 875 - 875

Published: May 8, 2023

All currently approved antibiotics are being met by some degree of resistance the bacteria they target. Biofilm formation is one crucial enablers bacterial resistance, making it an important process to target for overcoming antibiotic resistance. Accordingly, several drug delivery systems that biofilm have been developed. One these based on lipid-based nanocarriers (liposomes), which shown strong efficacy against biofilms pathogens. Liposomes come in various types, namely conventional (charged or neutral), stimuli-responsive, deformable, targeted, and stealth. This paper reviews studies employing liposomal formulations medically salient gram-negative gram-positive species reported recently. When comes species, types were be efficacious Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, members genera Klebsiella, Salmonella, Aeromonas, Serratia, Porphyromonas, Prevotella. A range also effective biofilms, including mostly Staphylococcal strains, Staphylococcus aureus, epidermidis, saprophyticus subspecies bovis, followed Streptococcal strains (pneumonia, oralis, mutans), Cutibacterium acnes, Bacillus subtilis, Mycobacterium avium, avium subsp. hominissuis, abscessus, Listeria monocytogenes biofilms. review outlines benefits limitations using as means combat different multidrug-resistant bacteria, urging investigation effects gram-stain efficiency inclusion pathogenic previously unstudied.

Language: Английский

Citations

24