Stresses,
Journal Year:
2025,
Volume and Issue:
5(1), P. 7 - 7
Published: Jan. 15, 2025
Chronic
pain
represents
a
complex
and
debilitating
condition
that
affects
millions
of
people
worldwide,
significantly
compromising
their
quality
life.
The
conventional
approach
to
treating
this
type
often
relies
on
the
use
opioid
analgesics
anti-inflammatory
drugs.
While
these
agents
are
effective
in
short
term,
they
present
several
limitations,
including
risk
dependence,
severe
side
effects,
and,
some
cases,
ineffectiveness
reducing
pain.
In
context,
medical
cannabis
has
emerged
as
promising
therapeutic
alternative,
given
its
potential
ability
relieve
effectively
with
favorable
safety
profile.
This
work
aims
provide
comprehensive
up-to-date
review
existing
literature
effects
treatment
chronic
Cannabis
sativa
contains
pharmacologically
active
compounds,
most
prominent
which
delta-9-tetrahydrocannabinol
(∆9-THC)
cannabidiol
(CBD),
interact
body’s
endocannabinoid
system,
thereby
modulating
response.
Clinical
evidence
shown
cannabinoids
can
reduce
intensity
pain,
particularly
cases
neuropathy,
multiple
sclerosis,
arthritis,
other
painful
conditions
unresponsive
treatments.
However,
full
integration
into
clinical
practice
faces
significant
obstacles,
need
for
standardized
dosing,
long-term
data,
regulatory
frameworks.
These
issues,
alongside
concerns
over
adverse
drug
interactions,
must
be
addressed
unlock
cannabinoids,
patients,
who
endure
both
physical
suffering
added
burden
stress.
Drug Design Development and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 569 - 583
Published: Jan. 1, 2025
Background:
Doxorubicin
(DOX)
is
a
chemotherapeutic
agent
widely
used
for
cancer
treatment
and
has
non-negligible
cardiotoxicity.Some
previous
studies
have
reported
that
cannabidiol
(CBD)
cardioprotective
effects.In
this
study,
we
evaluated
the
protective
effects
of
CBD
against
DOX-induced
cardiomyocyte
injury,
explored
downstream
molecular
mechanism.Methods
Materials:
GSE193861,
containing
healthy
myocardial
tissues
with
was
analyzed
to
screen
involved
proteins
pathways.Molecular
docking
performed
identify
candidate
drugs.After
H9c2
cells
were
treated
DOX
CBD,
their
viability,
oxidative
stress,
apoptosis
assessed.After
YAP
depletion,
role
Hippo
pathway
in
function
investigated.C57BL/6
mice
establish
an
vivo
model,
verteporfin
(VP)
treat
mice.Histological
analyses
immunofluorescence
evaluate
tissue
stress
also
analyzed.Western
blotting
investigate
regulatory
on
apoptosis-related
pathways.Results:
Bioinformatic
analysis
suggested
crucial
injury.Molecular
showed
targeted
multiple
regulators
pathway.CBD
injury
both
vitro
regulated
activity
cardiomyocytes.After
inactivation
by
knockdown
or
VP
intervention,
reversed.Conclusion:
For
first
time,
revealed
likely
reduce
regulating
signaling
pathway.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5749 - 5749
Published: May 25, 2024
Neurological
disorders
present
a
wide
range
of
symptoms
and
challenges
in
diagnosis
treatment.
Cannabis
sativa,
with
its
diverse
chemical
composition,
offers
potential
therapeutic
benefits
due
to
anticonvulsive,
analgesic,
anti-inflammatory,
neuroprotective
properties.
Beyond
cannabinoids,
cannabis
contains
terpenes
polyphenols,
which
synergistically
enhance
pharmacological
effects.
Various
administration
routes,
including
vaporization,
oral
ingestion,
sublingual,
rectal,
provide
flexibility
treatment
delivery.
This
review
shows
the
efficacy
managing
neurological
such
as
epilepsy,
neurodegenerative
diseases,
neurodevelopmental
disorders,
psychiatric
painful
pathologies.
Drawing
from
surveys,
patient
studies,
clinical
trials,
it
highlights
alleviating
symptoms,
slowing
disease
progression,
improving
overall
quality
life
for
patients.
Understanding
mechanisms
can
open
up
possibilities
using
this
plant
individual
needs.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(4), P. 369 - 369
Published: April 17, 2024
The
compounds
present
in
hemp
show
multidirectional
biological
activity.
It
is
related
to
the
presence
of
secondary
metabolites,
mainly
cannabinoids,
terpenes,
and
flavonoids,
synergy
their
aim
this
study
was
assess
activity
Henola
Cannabis
sativae
extract
its
combinations
with
selected
carriers
(polyvinyl
caprolactam–polyvinyl
acetate–polyethylene
glycol
graft
copolymer,
magnesium
aluminometasilicate,
hydroxypropyl-β-cyclodextrin)
terms
antimicrobial,
probiotic,
immunobiological
effects.
As
a
result
conducted
research,
antimicrobial
confirmed
relation
following
microorganisms:
Clostridium
difficile,
Listeria
monocytogenes,
Enterococcus
faecalis,
Staphylococcus
aureus,
pyrogenes,
Escherichia
coli,
Klebsiella
pneumoniae,
Salmonella
typhimurium,
Pseudomonas
aereuginosa,
Candida
albicans
(microorganism
count
reduced
from
~102
CFU
mL−1
<10
most
cases).
Additionally,
for
system
hydroxypropyl-β-cyclodextrin,
significant
probiotic
potential
against
bacterial
strains
established
Lactobacillus
acidophilus,
casei,
plantarum,
brevis,
rhamnosus,
reuteri,
Pediococcus
pentosaceus,
Lactococcus
lactis,
fermentum,
Streptococcus
thermophilus
increased
104–107).
In
immunomodulatory
properties,
it
determined
that
tested
systems
caused
changes
IL-6,
IL-8,
TNF-α
levels.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2025,
Volume and Issue:
169, P. 106030 - 106030
Published: Feb. 1, 2025
Bipolar
disorder
(BD)
is
characterized
by
a
complex
constellation
of
emotional,
cognitive,
and
psychomotor
disturbances,
each
deeply
intertwined
with
underlying
dysfunctions
in
large-scale
brain
networks
neurotransmitter
systems.
This
manuscript
integrates
recent
advances
neuroimaging,
neuromodulation,
pharmacological
research
to
provide
comprehensive
view
BD's
pathophysiology,
emphasizing
the
role
network-specific
their
clinical
manifestations.
We
explore
how
dysregulation
within
fronto-limbic
network,
particularly
involving
prefrontal
cortex
(PFC)
amygdala,
underpins
emotional
instability
that
defines
both
manic
depressive
episodes.
Additionally,
impairments
central
executive
network
(CEN)
default
mode
(DMN)
are
linked
cognitive
deficits,
hyperactivity
DMN
driving
rumination
inflexibility,
while
CEN
underactivity
contributes
attentional
lapses
impaired
function.
Psychomotor
symptoms,
which
oscillate
between
mania
retardation
depression,
closely
associated
imbalances
systems,
dopamine
serotonin,
basal
ganglia-thalamo-cortical
motor
pathway.
Recent
studies
indicate
these
disturbances
further
exacerbated
disruptions
connectivity,
leading
control
regulation.
Emerging
therapeutic
strategies
discussed,
focus
on
neuromodulation
techniques
such
as
transcranial
magnetic
stimulation
(TMS)
deep
(DBS),
show
promise
restoring
balance
critical
networks.
Furthermore,
interventions
modulate
synaptic
functioning
neuronal
plasticity
offer
potential
for
addressing
symptoms
BD.
underscores
need
an
integrative
treatment
approach
simultaneously
targets
neural
circuits
systems
address
full
spectrum
Drawing
advancements
neurobiological
models
frameworks,
this
proposal
outlines
pathway
development
precision-tailored
interventions.
These
approaches
designed
optimize
outcomes,
ultimately
striving
elevate
quality
life
individuals
living
bipolar
(BD),
remaining
firmly
grounded
latest
empirical
evidence
theoretical
insights.
Chemistry & Biodiversity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 11, 2025
Transient
receptor
potential
vanilloid
3
(TRPV3)
is
a
thermosensitive
calcium-permeable
ion
channel
and
has
function
in
sensory
perception,
epidermal
barrier
function,
inflammation
keratinocyte
proliferation.
TRPV3
dysfunction
linked
with
chronic
pain,
atopic
dermatitis
neurodegenerative
disorders.
This
study
compared
the
binding
efficacy
molecular
dynamics
of
cannabidiol-
eugenol-TRPV3
complex(s),
elucidating
their
ligand-protein
dynamics.
Computational
methods,
including
density
functional
theory,
docking
simulations,
assessed
electronic
properties,
affinities
interaction
stability,
respectively.
Cannabidiol
showed
higher
affinity
(-7.73
±
0.73
kcal/mol)
than
eugenol
(-6.0
0.05
kcal/mol),
driven
by
denser
hydrophilic
hydrophobic
contacts.
Molecular
revealed
cannabidiol-TRPV3
complex
steady
atomic
deviation
protein
compactness.
Furthermore,
cannabidiol-induced
diverse
conformational
states,
while
exhibited
greater
flexibility.
These
findings
highlight
cannabidiol's
stable,
dynamic
TRPV3,
suggesting
its
to
exert
TRPV3-mediated
biological
effects.
In
contrast,
may
serve
transient
modulation.
offers
insights
into
ligand-ion
interactions,
guiding
drug
development
for
TRPV3-related
conditions.
Exploration of Neuroprotective Therapy,
Journal Year:
2025,
Volume and Issue:
5
Published: March 9, 2025
Neurodegenerative
diseases
are
a
complex
ensemble
of
ailments
characterized
by
progressive
neuronal
deterioration
and
ultimate
loss,
resulting
in
drastic
impairments
memory,
cognition
other
brain
functions.
These
incapacitating
conditions
challenging
for
the
public
health
system
worldwide,
with
unfortunately
no
real
cure
lack
efficient
drugs
capable
delaying
or
reversing
these
diseases.
In
this
context,
endocannabinoid
exogenous
cannabinoids
represent
an
interesting
field
research
due
to
numerous
studies
highlighting
neuroprotective
effect
from
different
sources,
i.e.,
endogenous,
phytocannabinoids,
synthetic
cannabinoids.
This
review
highlights
multilayered
effects
block
progression
neurodegeneration
minimize
deleterious
insults
that
affect
brain.
We
illustrate
examples
showing
main
modulate
components
response
at
level
three
major
mechanisms
involved
neurodegeneration:
neuroinflammation,
excitotoxicity,
oxidative
stress.
Exploration of Neuroprotective Therapy,
Journal Year:
2025,
Volume and Issue:
5
Published: March 9, 2025
Neurodegenerative
diseases
are
a
complex
ensemble
of
ailments
characterized
by
progressive
neuronal
deterioration
and
ultimate
loss,
resulting
in
drastic
impairments
memory,
cognition
other
brain
functions.
These
incapacitating
conditions
challenging
for
the
public
health
system
worldwide,
with
unfortunately
no
real
cure
lack
efficient
drugs
capable
delaying
or
reversing
these
diseases.
In
this
context,
endocannabinoid
exogenous
cannabinoids
represent
an
interesting
field
research
due
to
numerous
studies
highlighting
neuroprotective
effect
from
different
sources,
i.e.,
endogenous,
phytocannabinoids,
synthetic
cannabinoids.
This
review
highlights
multilayered
effects
block
progression
neurodegeneration
minimize
deleterious
insults
that
affect
brain.
We
illustrate
examples
showing
main
modulate
components
response
at
level
three
major
mechanisms
involved
neurodegeneration:
neuroinflammation,
excitotoxicity,
oxidative
stress.
