MXenes Antibacterial Properties and Applications: A Review and Perspective

Small, Journal Year: 2023, Volume and Issue: 19(14)

Published: Jan. 5, 2023

The mutations of bacteria due to the excessive use antibiotics, and generation antibiotic-resistant have made development new antibacterial compounds a necessity. MXenes emerged as biocompatible transition metal carbide structures with extensive biomedical applications. This is related MXenes' unique combination properties, including multifarious elemental compositions, 2D-layered structure, large surface area, abundant terminations, excellent photothermal photoelectronic properties. focus this review application MXenes, which has attracted attention researchers since 2016. A quick overview synthesis strategies provided then summarizes effect various factors (including structural optical charges, flake size, dispersibility) on biocidal activity MXenes. main mechanisms for deactivating by are discussed in detail rupturing bacterial membrane sharp edges nanoflakes, generating reactive oxygen species (ROS), bacteria. Hybridization other organic inorganic materials can result improved activities different applications such wound dressings water purification. Finally, challenges perspectives MXene nanomaterials agents presented.

Language: Английский

---

Supramolecular Thermo‐Contracting Adhesive Hydrogel with Self‐Removability Simultaneously Enhancing Noninvasive Wound Closure and MRSA‐Infected Wound Healing

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(13)

Published: April 15, 2022

Conventional wound closure and dressing are two crucial, time-consuming but isolated principles in care. Even though tissue adhesive opens a new era for closure, the method biomaterial that can simultaneously achieve noninvasive promote healing highly appreciated. Herein, novel supramolecular poly(N-isopropylacrylamide) hybrid hydrogel composed of quaternized chitosan-graft-β-cyclodextrin, adenine, polypyrrole nanotubes via host-guest interaction hydrogen bonds is developed. The demonstrates thermal contraction 47% remaining area after 2 h at 37 ℃ adhesion 5.74 kPa, which essential multiple mechanical biological properties including suitable properties, self-healing, on-demand removal, antioxidant, hemostasis, photothermal/intrinsic antibacterial activity (higher 99% killing ratio within 5 min irradiation). In both full-thickness skin incision excision models, reveals significant 24 post-surgery. acute methicillin-resistant Staphylococcus aureus-infected assays, wounds treated with demonstrate enhanced rapid rate, mild inflammatory response, advanced angiogenesis, well-arranged collagen fibers. Altogether, results indicate promising synchronously healing.

Language: Английский

---

Emerging Trends in Nanomaterials for Antibacterial Applications

International Journal of Nanomedicine, Journal Year: 2021, Volume and Issue: Volume 16, P. 5831 - 5867

Published: Aug. 1, 2021

Abstract: Around the globe, surges of bacterial diseases are causing serious health threats and related concerns. Recently, metal ion release photodynamic photothermal effects nanomaterials were demonstrated to have substantial efficiency in eliminating resistance bacteria. Nanomaterials with characteristics such as surface plasmonic resonance, photocatalysis, structural complexities, optical features been utilized control release, generate reactive oxygen species, produce heat for antibacterial applications. The superior present an opportunity explore enhance their activities leading clinical In this review, we comprehensively list three different mechanisms therapy, therapy based on nanomaterials. These divided into respective subgroups accordance recent achievements, showcasing prospective challenges opportunities clinical, environmental, fields. Keywords: nanomaterials, ions, photodynamic, photothermal, mechanism, species Graphical

Language: Английский

---

Antibacterial Hybrid Hydrogels

Macromolecular Bioscience, Journal Year: 2020, Volume and Issue: 21(1)

Published: Sept. 3, 2020

Abstract Bacterial infectious diseases and bacterial‐infected environments have been threatening the health of human beings all over world. In view increased bacteria resistance caused by overuse or improper use antibiotics, antibacterial biomaterials are developed as substitutes for antibiotics in some cases. Among them, hydrogels attracting more attention due to easy preparation process diversity structures changing their chemical cross‐linkers via covalent bonds noncovalent physical interactions, which can endow them with various specific functions such high toughness stretchability, injectability, self‐healing, tissue adhesiveness rapid hemostasis, loading controlled drug release, superior biocompatibility antioxidation well good conductivity. this review, recent progress hydrogel including fabrication methodologies, interior structures, performances, mechanisms, applications is summarized. According bacteria‐killing modes hydrogels, several representative silver nanoparticles‐based hydrogel, photoresponsive photothermal photocatalytic, self‐bacteria‐killing inherent peptides cationic polymers, antibiotics‐loading focused on. Furthermore, current challenges discussed future perspectives field also proposed.

Language: Английский

---

Copper sulfide with morphology-dependent photodynamic and photothermal antibacterial activities

Journal of Colloid and Interface Science, Journal Year: 2021, Volume and Issue: 607, P. 1825 - 1835

Published: Oct. 8, 2021

Language: Английский

---