Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 154, P. 454 - 466
Published: Oct. 12, 2022
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(9)
Published: Dec. 22, 2021
Abstract The transmission of SARS‐CoV‐2 coronavirus has led to the COVID‐19 pandemic. Nucleic acid testing while specific limitations for mass surveillance. One alternative is main protease (M pro ) due its functional importance in mediating viral life cycle. Here, we describe a combination modular substrate and gold colloids detect M via visual readout. strategy involves zwitterionic peptide that carries opposite charges at C‐/N‐terminus exploit recognition by . Autolytic cleavage releases positively charged moiety assembles nanoparticles with rapid color changes ( t <10 min). We determine limit detection breath condensate matrices nM. further assayed ten COVID‐negative subjects found no false‐positive result. In light simplicity, our test not limited an equipped laboratory, but also amenable integrating as portable point‐of‐care devices including those on face‐coverings.
Language: Английский
Citations
65
Science Advances, Journal Year: 2022, Volume and Issue: 8(2)
Published: Jan. 12, 2022
Long-term pharmacotherapy, serving as the main therapeutic approach for epilepsy prophylaxis, has suffered from limited efficacy and potential side effects because of blood-brain barrier (BBB) untimely medication. Here, we reported a nanoengineered drug delivery system synergistic brain-targeting on-demand release antiepileptic drugs (AEDs). The dopamine-pyrrole hybrid can improve efficiency through combination receptor-mediated transcytosis BBB disruption–enabled transport induced by photothermal conversion near-infrared light. Incorporation polydopamine endowed with enhanced conductivity sensitivity, giving sustained (2 hours) rapid (30 s) in response to epileptiform discharges. Acute, continuous, spontaneous seizure models validated that could inhibit seizures upon abnormalities, treated one-fifth conventional dosage. Complemented satisfactory biosafety results, this “smart” modality is promising be an effective safe strategy index AEDs epilepsy.
Language: Английский
Citations
64
Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)
Published: Feb. 8, 2022
Abstract Immunogenic cell death (ICD) through apoptosis or necroptosis is widely adopted to improve the therapeutic effect in cancer treatment by triggering a specific antitumor immunity. However, tumor resistance apoptosis/necroptosis seriously impedes effect. Recently, ferroptosis featured with excessive lipid peroxidation demonstrated capable of bypassing kill cells. To date, numerous efficient inducers are developed and successfully utilized for sensitizing cells ferroptosis. Unfortunately, these can hardly generate adequate immunogenicity during induction ferroptotic death, which distinctly attenuates efficacy immune response, therefore leads unsatisfactory Herein, novel high‐performance photothermal nanoparticle (TPA‐NDTA NP) designed exploiting energy via excited‐state intramolecular motion employed immensely assisting inducer evoke highly ICD pathway. Tumor models poor used demonstrate tremendously enhanced endowed immunogenic vitro vivo virtue NPs. This study sheds new light on previously unrecognized facet boosting achieving satisfactory therapy.
Language: Английский
Citations
60
Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(7), P. 999 - 999
Published: July 1, 2021
Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, physiological conditions, late-stage diabetes, dermatitis, or psoriasis. These events locally characterized by an intense inflammatory response, a high generation harmful free radicals, impairment the immune response regulation, which can profoundly change tissue’ repair process, vulnerability, functionality. Moreover, diabetes diffusion, antibiotic resistance, abuse aggressive soaps disinfectants following COVID-19 emergency could be causes for future spreading disorders. In last years, hydroxycinnamic acids derivatives have been investigated applied several research fields their anti-oxidant, anti-inflammatory, anti-bacterial activities. First, this study, we give overview these natural molecules’ current source applications. Afterwards, review potential role valid alternatives therapies, supporting management rebalancing disorders diseases at different levels. Also, will introduce recent advances design biomaterials loaded with phenolic compounds, specifically suitable treatments. Lastly, suggest perspectives introducing treating
Language: Английский
Citations
56
Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 154, P. 454 - 466
Published: Oct. 12, 2022
Language: Английский
Citations
47