Cuproptosis-immunotherapy using PD-1 overexpressing T cell membrane-coated nanosheets efficiently treats tumor

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 502 - 512

Published: Sept. 9, 2023

Language: Английский

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Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 22, 2023

Biological membranes often play important functional roles in biomimetic drug delivery systems. We discover that the circulation time and targeting capability of biological membrane coated nanovehicles can be significantly improved by reducing cholesterol level coating membrane. A proof-of-concept system using cholesterol-reduced PD-1-overexpressed T cell to deliver a photothermal agent STING agonist is thus fabricated. Comparing with normal membrane, this engineered increases tumor accumulation ~2-fold. In melanoma model male mice, tumors are eliminated no recurrence >80% mice after intravenous injection laser irradiation; while colon cancer ~40% cured without irradiation. Data suggest escape immune surveillance avoid blood clearance keeping surface molecules exposed. summary, we develop simple, effective, safe widely-applicable modification strategy. This "subtractive" strategy displays some advantages worth further development.

Language: Английский

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Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(1), P. 101 - 101

Published: Jan. 10, 2023

Polyphenols and their derivates, a kind of natural product distributed in herb plants, vegetables, fruits, are the most abundant antioxidants human diet have been found to display cancer-preventative effects several epidemiological studies. The scientific community has also validated anti-cancer bioactivities low toxicities polyphenolic compounds, including flavones, tannins, phenolic acids, anthocyanins, through vitro vivo However, stability, weak targeting ability, poor solubility, bioavailability pure agents significantly impaired treatment efficacy. Nowadays, nano-based technology applied surmount these restrictions maximize efficacy polyphenols. In this review, we summarize advantages related mechanisms polyphenols cancer treatment. Moreover, aiming at solubility vivo, delivery systems recent research developments highlighted. Herein, particular emphasis is mainly placed on widely used nanomaterials products, liposomes, micelles, nanogels. Finally, present an overview challenges future implementations compounds therapeutic field.

Language: Английский

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Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 1, 2024

Abstract Background Herbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers. Compared to traditional herbs, herbal lead improved bioavailability, enhanced stability, and reduced toxicity. Previous research indicates that medicine nanomaterials rapidly advancing making significant progress; however, bibliometric analysis knowledge mapping for currently lacking. We performed by retrieving publications related the Web of Science Core Collection (WoSCC) database spanning 2004 2023. Data processing was using R package Bibliometrix, VOSviewers, CiteSpace. Results In total, 1876 articles were identified, originating various countries, China being primary contributing country. The number in this field increases annually. Beijing University Chinese Medicine, Shanghai Traditional Saveetha India prominent institutions domain. Journal “International Nanomedicine” has highest publications. authors these reached 8234, Yan Zhao, Yue Zhang, Huihua Qu most prolific Zhao frequently cited author. “Traditional medicine,” “drug delivery,” “green synthesis” main focal points. Themes such as synthesis,” “curcumin,” “wound healing,” “carbon dots” may represent emerging areas. Conclusions Our study findings assist identifying latest frontiers hot topics, providing valuable references scholars investigating role nanotechnology medicine. Graphical

Language: Английский

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Progress in the Regulation of Immune Cells in the Tumor Microenvironment by Bioactive Compounds of Traditional Chinese Medicine

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2374 - 2374

Published: May 17, 2024

The tumor microenvironment (TME) can aid cells in evading surveillance and clearance by immune cells, creating an internal environment conducive to cell growth. Consequently, there is a growing focus on researching anti-tumor immunity through the regulation of within TME. Various bioactive compounds traditional Chinese medicine (TCM) are known alter balance modulating activity In turn, this enhances body’s response, thus promoting effective elimination cells. This study aims consolidate recent findings regulatory effects from TCM regulate TME macrophages, dendritic natural killer T lymphocytes their checkpoints. has long history having been used clinical practice China. contains various chemical constituents, including alkaloids, polysaccharides, saponins flavonoids. These components activate thereby improving systemic functions maintaining overall health. review, progress relation derived will be covered, provides basis for further in-depth research development field immunomodulation using TCM.

Language: Английский

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Bimetallic Nanozymes‐Integrated Parachute‐Like Au₂Pt@PMO@ICG Janus Nanomotor with Dual Propulsion for Enhanced Tumor Penetration and Synergistic PTT/PDT/CDT Cancer Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: Aug. 12, 2024

Abstract Nanocatalytic therapeutic agents with triple synergistic treatment modes of chemodynamic therapy (CDT), photothermal (PTT) and photodynamic (PDT) are emerging nanomaterials in malignancy treatment. Nevertheless, the passive diffusion transport result poor permeability tumor lesions, severely affecting effectiveness therapy. Herein, a dual‐source‐driven parachute‐like Au 2 Pt@PMO@ICG Janus nanomotor (APIJNS) is prepared by an interfacial energy‐mediated anisotropic growth strategy for PTT‐mediated CDT/PDT cancer Such can realize self‐thermophoresis drive under trigger near‐infrared light, which effectively enhance active uptake APIJNS tissue, thus achieving efficient PTT/PDT/CDT effect. In addition, exhibits high‐efficiency catalase (CAT)‐like activity catalyze overexpressed H O microenvironment (TME) to generate oxygen (O ), not only alleviating hypoxia lesion, but also converting it into singlet ( 1 ) activate photosensitizer ICG, PDT. This work provides new ideas enhancing improving dual‐drive nanomotors based on dual noble metal nanozymes.

Language: Английский

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Biomaterials to regulate tumor extracellular matrix in immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 149 - 166

Published: Oct. 11, 2024

Language: Английский

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Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 23, 2023

Cancer causes many deaths worldwide each year, especially due to tumor heterogeneity leading disease progression and treatment failure. Targeted of heterogeneous population cells - cancer stem is still an issue in protecting affected individuals against associated multidrug resistance progression. Nanotherapeutic agents have the potential go beyond state-of-the-art approaches overall management. Specially assembled nanoparticles act as carriers for targeted drug delivery. Several nanodrugs already been approved by US Food Drug Administration (FDA) treating different types. Phytochemicals isolated from plants demonstrate considerable nanomedical applications oncology thanks their antioxidant, anti-inflammatory, anti-proliferative, other health benefits. Phytochemical-based NPs can enhance anticancer therapeutic effects, improve cellular uptake agents, mitigate side effects toxic treatments. Per evidence, phytochemical-based specifically target CSCs decreasing risks relapse metastatic manifestation. Therefore, this review focuses on current outlook targeting research studies consideration framework predictive, preventive, personalized medicine (3PM).

Language: Английский

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Succinct NIR-II absorbed croconic acid-julolidine molecule uniting Fe(III)-quercetin complex for efficient mild photothermal therapy of oropharyngeal carcinoma

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 150907 - 150907

Published: April 1, 2024

Language: Английский

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Nanoparticle-mediated immunogenic cell death for cancer immunotherapy

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 656, P. 124045 - 124045

Published: March 30, 2024

Language: Английский

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