Cuproptosis: Harnessing Transition Metal for Cancer Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 19581 - 19599

Published: Oct. 11, 2023

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They act constituents of metalloenzymes involved cellular metabolism, function signaling molecules to regulate the proliferation metastasis tumors, are integral components metal-based anticancer drugs. Notably, recent research reveals that excessive copper can also modulate occurrence programmed cell death (PCD), known cuprotosis, cancer cells. This modulation occurs through disruption tumor metabolism induction proteotoxic stress. discovery uncovers a mode interaction between transition metals proteins, emphasizing intricate link homeostasis metabolism. Moreover, they provide innovative therapeutic strategies for precise diagnosis treatment malignant tumors. At crossroads chemistry oncology, we undertake comprehensive review elucidating molecular mechanisms underpinning cuproptosis. Additionally, summarize current nanotherapeutic approaches target cuproptosis an overview available laboratory clinical methods monitoring this process. In context emerging concepts, challenges, opportunities, emphasize significant potential nanotechnology advancement field.

Language: Английский

---

Converting CO₂ into Value‐Added Products by Cu₂O‐Based Catalysts: From Photocatalysis, Electrocatalysis to Photoelectrocatalysis

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 11, 2023

Abstract Converting CO 2 into value‐added products by photocatalysis, electrocatalysis, and photoelectrocatalysis is a promising method to alleviate the global environmental problems energy crisis. Among semiconductor materials applied in catalytic reduction, Cu O has advantages of abundant reserves, low price friendliness. Moreover, unique adsorption activation properties for , which conducive generation C 2+ through CC coupling. This review introduces basic principles reduction summarizes pathways 1 products. The factors affecting performance are further discussed from perspective reaction environment, medium, novel reactor design. Then, O‐based catalysts summarized several optimization strategies enhance their stability redox capacity discussed. Subsequently, application photocatalytic, electrocatalytic, photoelectrocatalytic described. Finally, opportunities, challenges research directions field presented, guidance its wide fields provided.

Language: Английский

---

Electrochemical NO₃^– Reduction Catalyzed by Atomically Precise Ag₃₀Pd₄ Bimetallic Nanocluster: Synergistic Catalysis or Tandem Catalysis?

ACS Nano, Journal Year: 2023, Volume and Issue: 17(13), P. 12747 - 12758

Published: June 28, 2023

Electrochemically converting NO3- compounds into ammonia represents a sustainable route to remove industrial pollutants in wastewater and produce valuable chemicals. Bimetallic nanomaterials usually exhibit better catalytic performance than the monometallic counterparts, yet unveiling reaction mechanism is extremely challenging. Herein, we report an atomically precise [Ag30Pd4 (C6H9)26](BPh4)2 (Ag30Pd4) nanocluster as model catalyst toward electrochemical reduction (eNO3-RR) elucidate different role of Ag Pd site unveil comprehensive mechanism. Ag30Pd4 homoleptic alkynyl-protected superatom with 2 free electrons, it has metal core where 4 atoms are located at subcenter core. Furthermore, exhibits excellent eNO3-RR robust stability for prolonged operation, can achieve highest Faradaic efficiency NH3 over 90%. In situ Fourier-transform infrared study revealed that plays more critical NO2-, while makes major contribution catalyze NO2- NH3. The bimetallic adopts tandem rather synergistic effect eNO3-RR. Such finding was further confirmed by density functional theory calculations, they disclosed most preferable binding NO3-, which then binds water molecule release NO2-. Subsequently, transfer vicinal exposed promote formation.

Language: Английский

---

Silver nanoparticles immobilized on crosslinked vinyl polymer for catalytic reduction of nitrophenol: experimental and computational studies

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 3, 2025

Language: Английский

---

Modification engineering over single-atom catalysts for efficient heterogeneous photocatalysis

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216468 - 216468

Published: Jan. 21, 2025

Language: Английский

---

Purifying water with silver nanoparticles (AgNPs)-incorporated membranes: Recent advancements and critical challenges

Water Research, Journal Year: 2022, Volume and Issue: 222, P. 118901 - 118901

Published: July 28, 2022

Language: Английский

---

A Novel Green Preparation of Ag/RGO Nanocomposites with Highly Effective Anticancer Performance

Polymers, Journal Year: 2021, Volume and Issue: 13(19), P. 3350 - 3350

Published: Sept. 30, 2021

The efficacy of current cancer therapies is limited due to several factors, including drug resistance and non-specific toxic effects. Due their tuneable properties, silver nanoparticles (Ag NPs) graphene derivative-based nanomaterials are now providing new hope treat with minimum side Here, we report a simple, inexpensive, eco-friendly protocol for the preparation silver-reduced oxide nanocomposites (Ag/RGO NCs) using orange peel extract. This work was planned curtail use chemicals, improve anticancer performance cytocompatibility Ag/RGO NCs. Aqueous extract peels abundant in phytochemicals that act as reducing stabilizing agents green synthesis Ag NPs NCs from nitrate (GO). Moreover, flavonoid present potent agent. Green-prepared were characterized by UV-visible spectrophotometry, transmission electron microscopy (TEM), scanning (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), dynamic light scattering (DLS). results study demonstrated killing potential against human breast (MCF7) lung (A549) cells two-fold pure NPs. normal epithelial (MCF10A) fibroblasts (IMR90) higher than mechanistic indicated induce toxicity through pro-oxidant reactive oxygen species generation antioxidant glutathione depletion provided novel highly effective better cytocompatibility.

Language: Английский

---

A review on the synthesis and applications of sustainable copper-based nanomaterials

Green Chemistry, Journal Year: 2022, Volume and Issue: 24(9), P. 3502 - 3573

Published: Jan. 1, 2022

A comprehensive review of the synthesis and applications Cu Cu-based nanomaterials. variety including organic reactions, photocatalysis, environmental remediation, sensors have been included.

Language: Английский

---

Biogenic adsorbents for removal of drugs and dyes: A comprehensive review on properties, modification and applications

Chemosphere, Journal Year: 2023, Volume and Issue: 338, P. 139477 - 139477

Published: July 11, 2023

This comprehensive review explores the potential and versatility of biogenic materials as sustainable environmentally benign alternatives to conventional adsorbents for removal drugs dyes. Biogenic derived from plants, animals, microorganisms, algae biopolymers have bioactive compounds that interact with functional groups pollutants, resulting in their binding sorbent. These can be modified mechanically, thermally chemically enhance adsorption properties. hybrid composites, which integrate characteristics more than one material, also been fabricated. Additionally, microorganisms are analyzed ability uptake pollutants. Various influential factors contribute process discussed. The challenge, limitations future prospects research reviewed bridging gap between large scale application laboratory scale. review, involves a combination various adsorbents, going beyond existing literature where typically only specific reported. covers isotherms, kinetics, desorption studies providing an improved framework effective use removing pharmaceuticals dyes wastewater.

Language: Английский

---

Engineering triple internal electric fields in Ag NWs@BaTiO3 composites for ultrasonic-visible-light driven antibacterial activity

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 463, P. 142310 - 142310

Published: March 9, 2023

Language: Английский

---