Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 33(9), P. 4146 - 4156
Published: Feb. 22, 2022
Language: Английский
Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5977 - 6039
Published: Feb. 2, 2022
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target for cancer immunotherapy. Activation the intracellular STING protein triggers production multifaceted array immunostimulatory molecules, which, in proper context, can drive dendritic cell maturation, antitumor macrophage polarization, T priming and activation, natural killer vascular reprogramming, and/or death, resulting immune-mediated tumor elimination generation immune memory. Accordingly, there significant amount ongoing preclinical clinical research toward further understanding role surveillance as well development modulators strategy to stimulate immunity. Yet, efficacy agonists limited by many drug delivery pharmacological challenges. Depending on class agonist desired administration route, these may include poor stability, immunocellular toxicity, immune-related adverse events, or lymph node targeting retention, low uptake delivery, complex dependence magnitude kinetics signaling. This review provides concise summary pathway, highlighting recent biological developments, immunological consequences, implications delivery. also offers critical analysis an expanding arsenal chemical strategies that are being employed enhance efficacy, safety, utility lastly draws attention several opportunities therapeutic advancements.
Language: Английский
Citations
211
Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 5136 - 5174
Published: Jan. 1, 2022
Recent years have witnessed increasingly rapid advances in nanocarrier-based biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as multipurpose and constructed vectors formed via intramolecular cross-linking to generate drug delivery systems, which is attributed predominantly their satisfactory biocompatibility, bio-responsiveness, high stability, low toxicity. Recently, immunotherapy has experienced unprecedented growth become the preferred strategy cancer treatment, mainly involves mobilisation of immune system an enhanced anti-tumour immunity tumour microenvironment. Despite inspiring success, immunotherapeutic strategies are limited due response rates immune-related adverse events. Like other nanomedicines, nanogels comparably by lower focal enrichment upon introduction into organism injection. Because three-dimensional cross-linked aqueous materials that exhibit similar properties natural tissues structurally stable, they can comfortably cope with shear forces serum proteins bloodstream, longer circulation life increases chance nanogel accumulation tumour, conferring deep penetration. The large specific surface area reduce or eliminate off-target effects introducing stimuli-responsive functional groups, allowing multiple physical chemical modifications purposes improve targeting cell subpopulations organs, increasing bioavailability drug, a events on therapies. slow release reaching site facilitates long-term awakening host's system, ultimately achieving therapeutic effects. As effective candidate immunotherapy, nanogel-based been widely used. In this review, we summarize recent deliver immunomodulatory small molecule drugs, antibodies, genes cytokines, target antigen presenting cells, form vaccines, enable chimeric receptor (CAR)-T therapy. Future challenges well expected feasible prospects clinical also highlighted.
Language: Английский
Citations
131
Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(30)
Published: May 7, 2022
Abstract Pickering emulsions are particle‐stabilized surfactant‐free dispersions composed of two immiscible liquid phases, and emerge as attractive catalysis platform to surpass traditional technique barrier in some cases. In this review, we have comprehensively summarized the development applications since pioneering work 2010. The explicit mechanism for will be initially discussed clarified. Then, summarization is given design strategy amphiphilic emulsion catalysts categories intrinsic extrinsic amphiphilicity. progress unconventional catalytic reactions further described, especially polarity/solubility difference‐driven phase segregation, “smart” reaction system, continuous flow catalysis, interfacial biocatalysis. Challenges future trends finally outlined.
Language: Английский
Citations
123
Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(22)
Published: Feb. 27, 2023
Abstract The discovery of the medicinal properties gold complexes has fuelled design and synthesis new anticancer metallodrugs, which have received special attention due to their unique modes action. Current research in development compounds with therapeutic is predominantly focused on molecular drug leads superior pharmacological activities, e.g., by introducing targeting features. Moreover, intensive aims at improving physicochemical compounds, such as chemical stability solubility physiological environment. In this regard, encapsulation nanocarriers or grafting onto targeted delivery vectors could lead nanomedicines that eventually reach clinical applications. Herein, we provide an overview state‐of‐the‐art progress andmore importantly thoroughly revise nanoparticle‐based systems for chemotherapeutics.
Language: Английский
Citations
107
Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(12), P. 7782 - 7853
Published: May 15, 2023
The high selectivity and affinity of antibodies toward their antigens have made them a highly valuable tool in disease therapy, diagnosis, basic research. A plethora chemical genetic approaches been devised to make accessible more "undruggable" targets equipped with new functions illustrating or regulating biological processes precisely. In this Review, addition introducing how naked various antibody conjugates (such as antibody-drug conjugates, antibody-oligonucleotide antibody-enzyme etc.) work therapeutic applications, special attention has paid chemistry tools helped optimize the outcome (i.e., enhanced efficacy reduced side effects) facilitate multifunctionalization antibodies, focus on emerging fields such targeted protein degradation, real-time live-cell imaging, catalytic labeling decaging spatiotemporal control well engagement inside cells. With advances modern biotechnology, well-designed derivatives via size miniaturization together efficient delivery systems emerged, which gradually improved our understanding important paved way pursue novel for potential treatments diseases.
Language: Английский
Citations
66
ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(2), P. 309 - 334
Published: Jan. 24, 2024
The emergence of peptide–drug conjugates (PDCs) that utilize target-oriented peptide moieties as carriers cytotoxic payloads, interconnected with various cleavable/noncleavable linkers, resulted in the key-foundation new era targeted therapeutics. They are capable retaining integrity blood circulatory system well releasing drugs at tumor microenvironment. Other valuable advantages specificity and selectivity toward targeted-receptors, higher penetration ability, drug-loading capacity, making them a suitable candidate to play their vital role promising carrier agents. In this review, we summarized types cell-targeting (CTPs) cell-penetrating peptides (CPPs) have broad applications advancement drug-delivery systems (DDS). Moreover, techniques overcome limitations peptide-chemistry for extensive implementation construct PDCs. Besides this, diversified breakthrough linker chemistry, ample knowledge payloads used PDCs recent years, mechanism action was critically discussed. principal aim is provide scattered one place help researchers understand pinching knots science PDC development, also progression bright future novel theranostics clinical practice.
Language: Английский
Citations
18
Progress in Materials Science, Journal Year: 2024, Volume and Issue: 143, P. 101248 - 101248
Published: Feb. 11, 2024
Language: Английский
Citations
18
Advanced Science, Journal Year: 2021, Volume and Issue: 8(18)
Published: July 29, 2021
Abstract This article provides a broad spectrum about the nanoprodrug fabrication advances co‐driven by prodrug and nanotechnology development to potentiate cancer treatment. The inherits features of both concept nanomedicine know‐how, attempts solve underexploited challenge in treatment cooperatively. Prodrugs can release bioactive drugs on‐demand at specific sites reduce systemic toxicity, this is done using special properties tumor microenvironment, such as pH value, glutathione concentration, overexpressed enzymes; or exogenous stimulation, light, heat, ultrasound. nanotechnology, manipulating matter within nanoscale, has high relevance certain biological conditions, been widely utilized therapy. Together, marriage strategy which shield side effects parent drug with pinpoint delivery capability conceived highly camouflaged Trojan horse maneuver cancerous threats.
Language: Английский
Citations
90
Antibodies, Journal Year: 2021, Volume and Issue: 10(4), P. 42 - 42
Published: Oct. 27, 2021
Antibody-drug conjugates (ADCs) are innovative biopharmaceutical products in which a monoclonal antibody is linked to small molecule drug with stable linker. Most of the ADCs developed so far for treating cancer, but there enormous potential using treat other diseases. Currently, ten have been approved by United States Food and Drug Administration (FDA), more than 90 under worldwide clinical development. Monoclonal antibodies evolved from research tools powerful therapeutics past 30 years. Tremendous strides made discovery, protein bioengineering, formulation, delivery devices. This manuscript provides an overview biology, chemistry, biophysical properties each component ADC design. review summarizes advances challenges field date, emphasis on conjugation, linker-payload novel payload classes, drug-antibody ratio (DAR), product The emphasizes lessons learned development oncology look towards future innovations enabling therapeutic indications. discusses resistance mechanisms ADCs, give opinion perspectives.
Language: Английский
Citations
75
Polymer Chemistry, Journal Year: 2022, Volume and Issue: 13(22), P. 3188 - 3269
Published: Jan. 1, 2022
In this review we describe advances in the design of self-immolative linkers and their application polymeric reporting systems.
Language: Английский
Citations
57