Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca²⁺/Cu²⁺ Dual-Ions Nano Trap for Breast Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 6975 - 6989

Published: Feb. 20, 2024

Regarded as one of the hallmarks tumorigenesis and tumor progression, evasion apoptotic cell death would also account for treatment resistance or failure during cancer therapy. In this study, a Ca2+/Cu2+ dual-ion "nano trap" to effectively avoid apoptosis by synchronously inducing paraptosis together with was successfully designed fabricated breast treatment. brief, disulfiram (DSF)-loaded amorphous calcium carbonate nanoparticles (NPs) were via gas diffusion method. Further on, Cu2+-tannic acid metal phenolic network embedded onto NPs surface self-assembling, followed mDSPE-PEG/lipid capping form DSF-loaded dual-ions trap". The as-prepared nanotrap undergo acid-triggered biodegradation upon being endocytosed cells within lysosome Ca2+, Cu2+, DSF releasing simultaneously. released Ca2+ could cause mitochondrial overload lead hydrogen peroxide (H2O2) overexpression. Meanwhile, Ca2+/reactive oxygen species-associated dysfunction death. Most importantly, be further induced strengthened toxic dithiocarbamate (DTC)–copper complexes formed Cu2+ combined DTC, metabolic products DSF. Additionally, will reduced intracellular glutathione generate Cu+, which can catalyze H2O2 produce hydroxyl radical Cu+-mediated Fenton-like reaction apoptosis. Both in vitro cellular assays vivo antitumor evaluations confirmed therapeutic efficiency dual ion nano trap. This study broaden cognition scope dual-ion-mediated multifunctional nanoplatform.

Language: Английский

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Exploring Sustainable Agriculture with Nitrogen-Fixing Cyanobacteria and Nanotechnology

Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2534 - 2534

Published: May 28, 2024

The symbiotic relationship between nitrogen-fixing cyanobacteria and plants offers a promising avenue for sustainable agricultural practices environmental remediation. This review paper explores the molecular interactions nanoparticles, shedding light on their potential synergies in nanotechnology. Delving into evolutionary history specialized adaptations of cyanobacteria, this highlights pivotal role fixing atmospheric nitrogen, which is crucial ecosystem productivity. discusses unique characteristics metal nanoparticles emerging applications agriculture, including improved nutrient delivery, stress tolerance, disease resistance. It delves complex mechanisms nanoparticle entry plant cells, intracellular transport, localization, uncovering impact root-shoot translocation systemic distribution. Furthermore, elucidates cellular responses to exposure, emphasizing oxidative stress, signaling pathways, enhanced uptake. as carriers essential nutrients implications nutrient-use efficiency crop yield are also explored. Insights modulation responses, resistance, phytoremediation strategies demonstrate multifaceted benefits agriculture. Current trends, prospects, challenges nanotechnology discussed, underscoring need responsible safe utilization. By harnessing power leveraging attributes paves way innovative, sustainable, efficient practices.

Language: Английский

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Amphiphilic Block Copolymer Nanostructures as a Tunable Delivery Platform: Perspective and Framework for the Future Drug Product Development

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(2), P. 541 - 563

Published: Jan. 19, 2024

Nanoformulation of active payloads or pharmaceutical ingredients (APIs) has always been an area interest to achieve targeted, sustained, and efficacious delivery. Various delivery platforms have explored, but loading APIs challenging because the chemical structural properties these molecules. Polymersomes made from amphiphilic block copolymers (ABCPs) shown enormous promise as a tunable API platform confer multifold advantages over lipid-based systems. For example, COVID booster vaccine comprising polymersomes encapsulating spike protein (ACM-001) recently completed Phase I clinical trial provides case for developing safe drug products based on ABCP platforms. However, several limitations need be resolved before they can reach their full potential. In this Perspective, we would like highlight such aspects requiring further development translating ABCP-based proof concept viable commercial product.

Language: Английский

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pH-responsive size-adjustable liposomes induce apoptosis of fibroblasts and macrophages for rheumatoid arthritis treatment

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 179, P. 256 - 271

Published: March 12, 2024

Language: Английский

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Control of biomedical nanoparticle distribution and drug release in vivo by complex particle design strategies

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 114634 - 114634

Published: Jan. 1, 2025

Language: Английский

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